Rosario Alicia Toro Campos

@article{nokey_59,

title = {Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT.},

author = {Rosario Toro},

doi = {10.1016/j.nut.2022.111599},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {Nutrition},

abstract = {- Otros autores: Jaramillo-Ospina AM, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R. 

 

- Cómo citar: Jaramillo-Ospina AM, Toro-Campos R, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R. Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT. Nutrition. 2022; 97:111599. doi: 10.1016/j.nut.2022.111599. PMID: 35193081. ISSN: 0899-9007. IF [JCR]: 4.893. Q2 

 

- Resumen: "Objective: The aim of this study was to assess the effects of an experimental formula (EF) with added whey protein-lipid concentrate (5 g/L; source of bovine milk fat globule membrane [bMFGM]) on growth, body composition, and safety through 24 mo of age in term infants. 

Methods: This was a double-blinded, randomized controlled trial conducted in Santiago, Chile. Infants were enrolled before 120 d and randomized to receive standard cow's milk-based formula (SF) or EF through the first year of life. Breastfed infants were the reference (HM). Growth (weight-for-age [WAZ], length-for-age [LAZ], BMI-for-age [BAZ], headcircumference-for-age [HCZ] z-scores); body composition (fat mass [FM] and fat-free mass, percentage body fat [%BF]); and adverse events through day 730 were recorded. Outcome trajectories were analyzed using a single generalized estimating equation testing the interaction between group and visit. Results: We recruited 582 infants (HM = 235; SF = 174; EF = 173); 478 (>80%) completed the study. At baseline, only WAZ was different between the formula groups (0.14 lower in EF versus SF group},

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pubstate = {published},

tppubtype = {article}

}

@article{nokey_83,

title = {Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT},

author = {Rosario Toro},

doi = {10.1093/cdn/nzaa054_086},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Curr Dev Nutr.},

abstract = {- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. 

 

- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT Curr Dev Nutr. 2021;4(Suppl 2):1014. doi: 10.1093/cdn/nzaa054_086. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3 

 

-Resumen: Objectives: To evaluate growth through 24 months of age in infants receiving added bovine milk fat globule membrane (MFGM) in infant formula through 12 months of age. Concentration of MFGM from bovine milk fractions and incorporation in infant formula may better approximate the composition of complex milk lipids in human milk. Methods: In the double-blind, randomized, controlled Chilean Infant Nutrition Trial (ChiNuT; NCT0262613), term infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age were randomized to receive: a standard cow's milk-based infant formula (SF},

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pubstate = {published},

tppubtype = {article}

}

@article{nokey_82,

title = {Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants Receiving Formula With Added Bovine Milk Fat Globule Membrane Through the First Year of Life: An RCT},

author = {Rosario Toro},

doi = {10.1093/cdn/nzab046_059},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Curr Dev Nutr.},

abstract = {- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. 

 

- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants 

Receiving Formula With Added Bovine Milk Fat Globule Membrane Through 

the First Year of Life: An RCT Curr Dev Nutr. 2021;5(Suppl 2):762. doi: 10.1093/cdn/nzab046_059. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3 

 

-Resumen: "Objectives: Bovine milk fat globule membrane (bMFGM) added in routine infant formula supports normal growth and safety through 24 mo of age in term infants. The impact on micronutrients and glucose-related biomarkers is assessed here. Methods: In this double-blind, randomized, controlled trial, formula-fed infants were enrolled (<120 days of age) and randomized to receive a standard cow´s milk-based infant formula (SF},

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pubstate = {published},

tppubtype = {article}

}

@article{nokey_102,

title = {Effect of feeding mode on infant growth and cognitive function: study protocol of the Chilean infant Nutrition randomized controlled Trial (ChiNuT).},

author = {Rosario Toro },

doi = {10.1186/s12887-020-02087-9},

year  = {2020},

date = {2020-00-00},

urldate = {2020-00-00},

journal = {BMC Pediatr.},

abstract = {- Otros autores: Algarín C, Peirano P, Peña M, Murguia-Peñiche T, Wu S, Uauy R. 

 

- Cómo citar: Toro-Campos R, Algarín C, Peirano P, Peña M, Murguia-Peñiche T, Wu S, Uauy R. Effect of feeding mode on infant growth and cognitive function: study protocol of the Chilean infant Nutrition randomized controlled Trial (ChiNuT). BMC Pediatr. 2020;20:225. doi: 10.1186/s12887-020-02087-9. PMID: 32423392. PMCID: PMC7236373. ISSN: 1471-2431. IF [JCR]: 2.567. Q3 

 

-Resumen: Background: A central aim for pediatric nutrition is to develop infant formula compositionally closer to human milk. Milk fat globule membranes (MFGM) have shown to have functional components that are found in human milk, suggesting that addition of bovine sources of MFGM (bMFGM) to infant formula may promote beneficial outcomes potentially helping to narrow the gap between infants who receive human breast milk or infant formula. The objective of the current study is to determine how the addition of bMFGM in infant formula and consumption in early infancy affects physical growth and brain development when compared to infants fed with a standard formula and a reference group of infants fed with mother's own milk. Methods: Single center, double-blind, and parallel randomized controlled trial. Planned participant enrollment includes: infants exclusively receiving breast milk (n = 200; human milk reference group; HM) and infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age (n = 340). The latter were randomized to receive one of two study formulas until 12 months of age: 1) cow's milk based infant formula that had docosahexaenoic (DHA) (17 mg/100 kcal) and arachidonic acid (ARA) (25 mg/100 kcal); 1.9 g protein/100 kcal; 1.2 mg Fe/100 kcal (Standard formula; SF) or 2) a similar infant formula with an added source of bovine MFGM (whey protein-lipid concentrate (Experimental formula; EF). Primary outcomes will be: 1) Physical growth (Body weight, length, and head circumference) at 730 days of age; and 2) Cognitive development (Auditory Event-Related Potential) at 730 days of age. Data will be analyzed for all participants allocated to each study feeding group. 

Discussion: The results of this study will complement the knowledge regarding addition of bMFGM in infant formula including support of healthy growth and improvement of neurodevelopmental outcomes.},

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pubstate = {published},

tppubtype = {article}

}

@article{nokey_117,

title = {Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.},

author = {Camila Corvalán and Ana Pereira and Rosario Toro },

doi = {10.1186/s13058-019-1168-2},

year  = {2019},

date = {2019-00-00},

urldate = {2019-00-00},

journal = {Breast Cancer Res.},

abstract = {- Otros autores: Terry MB, Michels KB, Brody JG, Byrne C, Chen S, Jerry DJ, Malecki KMC, Martin MB, Miller RL, Neuhausen SL, Silk K, Trentham-Dietz A, McDonald J, Oskar S, Knight J, Cai X, Rising C, Afanaseva D, Mullis M, Berry M, Bird J, Bradfield C, Gangnon R, Gould M, Hampton J, Lindberg S, Luongo S, Malecki K, Rolland B, Shull J, Gaudet M, Thornquist M, Aupperlee M, Haslam S, Hoshyar R, Kariagina A, Lopes J, Miller K, Morozova O, Newkirk C, Schwartz R, Thomas B, Totzkay D, Xie F, Silk K, Biro F, Fassler C, Giannini C, Pinney S, Troester M, Burke K, Herbstman J, Kehm R, Lilge L, Miller R, Perera F, Sahay D, Tehranifar P, Terry MB, Walker D, Zeinomar N, de Hoz M, Shepard P, Binder A, Michels K, Bessonneau V, Brody J, De La Rosa V, Ohayon J, Rudel R, et al. 

 

- Cómo citar: Terry MB, Michels KB, Brody JG, Byrne C, Chen S, Jerry DJ, Malecki KMC, Martin MB, Miller RL, Neuhausen SL, Silk K, Trentham-Dietz A, McDonald J, Oskar S, Knight J, Toro-Campos R, Cai X, Rising C, Afanaseva D, Mullis M, Berry M, Bird J, Bradfield C, Gangnon R, Gould M, Hampton J, Lindberg S, Luongo S, Malecki K, Rolland B, Shull J, Gaudet M, Thornquist M, Aupperlee M, Haslam S, Hoshyar R, Kariagina A, Lopes J, Miller K, Morozova O, Newkirk C, Schwartz R, Thomas B, Totzkay D, Xie F, Silk K, Biro F, Fassler C, Giannini C, Pinney S, Troester M, Burke K, Herbstman J, Kehm R, Lilge L, Miller R, Perera F, Sahay D, Tehranifar P, Terry MB, Walker D, Zeinomar N, de Hoz M, Shepard P, Binder A, Michels K, Bessonneau V, Brody J, De La Rosa V, Ohayon J, Rudel R, et al. Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Res. 2019;21(1):96. doi: 10.1186/s13058-019-1168-2. PMID: 31429809 / PMCID: PMC6701090. ISSN: 1465-5411. IF [JCR]: 8.408. Q1 

 

-Resumen: Background: The long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman’s life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention. 

Main text: Despite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland’s structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals—including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols—and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers. Conclusions: An integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective.},

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pubstate = {published},

tppubtype = {article}

}