Publicaciones académicas

@article{nokey,

title = {Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children},

author = {Ana Pereira and Camila Corvalán },

doi = {doi: 10.20945/2359-4292-2022-0353},

year  = {2024},

date = {2024-01-22},

journal = {Arch. Endocrinol Metab. },

abstract = {- Otros autores: Bravo C, Mericq V, Tobar HE, Miranda JP, Santos JL.



- Cómo citar:  Bravo C, Mericq V, Pereira A, Corvalán C, Tobar HE, Miranda JP, Santos JL. Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children. Arch Endocrinol Metab. 2024 Jan 29;68:e220353. doi: 10.20945/2359-4292-2022-0353. PMID: 38289144.



- Resumen: Objective: To assess the association between leptin/adiponectin ratio (LAR) and insulin resistance surrogates in prepubertal children.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Post menarcheal growth patterns in a contemporary cohort of Latino girls},

author = {Pedro Ferrer and Ana Pereira },

doi = {doi: 10.1159/000536506},

year  = {2024},

date = {2024-01-22},

journal = {Horm. Res. Paediatr.},

abstract = {-  Otros autores: Gaete X, Mericq V.



- Cómo citar: 



- Resumen: Introduction: Menarche is the last stage of pubertal development, which coincides with the completion of longitudinal growth. As a consequence of the lack of national and up-to-date data related to post-menarcheal (PM) growth, the aim of our work was to evaluate post menarcheal growth in a group of contemporary healthy Chilean girls followed, prospectively, until 4 years post-menarche. Methods: This study was nested within the GOCS cohort, in a prospective fashion. The girls were followed yearly after menarche for at least four years. We modeled each girl growth using a Super Imposition by Translation and Rotation (SITAR) model. Results: A total of 534 girls were evaluated prospectively, 399 girls had height measured two years after menarche, 421 after three years, and 364 of 534 had height measured at four year post menarche. Expected height gained PM, in the complete study group was 6.6 ± 2.5 cm. We observed that the largest gain in height occurred after the first year PM (3.8 1.5 cm). According to the age of menarche, the group with earlier menarche (< 11 years old ) had a greater height gain in cm after four years PM ( 8.2± 3.2 cm ) and the smallest gain was among girls with menarche at an age older than 13 yr (4.4±1.6) ( p<0.001). Age at menarche was significantly associated with all post menarche growth patterns (size, timing and intensity), indicating that girls with older age at menarche grew taller, later and slower than girls with younger age at menarche. Adjusting PM growth pattern by BMI maintained all these association. Applying the SITAR model specifically , girls experiencing menarche after the age of 13 years exhibited slower growth , occurring slightly earlier and with less intensity when adjusted by BMI at menarche . Conclusion: In a national and updated dataset we observed that girls grew until 4 years post menarche an average of 6.6 ± 2.5 cm., with greatest gain occurring in the first year PM , (3.8 ± 1.5 cm). Age at menarche was associated with menarche growth patterns.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Association between markers of adiposity during childhood and puberty onset in Latino girls},

author = {Ana Pereira and Pedro Ferrer and Camila Corvalán},

doi = {doi: 10.1210/clinem/dgad294},

year  = {2023},

date = {2023-06-05},

urldate = {2023-06-05},

journal = {J. Clin. Endocrinol. Metab.},

abstract = {- Otros autores: Binder A, Rojas J, Michels K, Mericq V. 



- Cómo citar: Pereira A, Ferrer P, Binder A, Rojas J, Michels K, Corvalán C, Mericq V. Association between markers of adiposity during childhood and puberty onset in Latino girls. J. Clin. Endocrinol. Metab. 2023;dgad294. Online ahead of print. doi: 10.1210/clinem/dgad294. PMID: 37226986. ISSN: 0021-972X. IF [JCR]: 5.8. Q1



- Resumen: Context: Prepubertal adiposity is associated with earlier puberty. It is unclear when this association starts, if all adiposity markers are similarly associated, and whether all pubertal milestones are similarly affected.



Objective: To evaluate the association between different adiposity markers during childhood and the timing of different pubertal milestones in Latino girls.

Design, setting and participants: Longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort (GOCS) recruited from childcare centers (mean age 3.5y) from the South East area of Santiago, Chile. Participants were singletons born between 2002-2003 within the normal birthweight range. Since 2006, a trained dietitian measured weight, height, waist circumference (WC) and skinfolds to estimate BMI CDC percentiles, central obesity, fat mass (%FM) and fat mass index (FMI = fat mass/height2).

Main outcome: since 2009, sexual maturation was assessed every 6 months to assess age at: i) thelarche, ii) pubarche, iii) menarche, and iv) age at peak height velocity (PHV).

Results: At thelarche, 12.5% were obese and 2% had central obesity. The median age of pubarche, menarche, and PHV were all associated with markers of adiposity at different time points during childhood; whereas thelarche only with %FM and FMI. Adiposity clusters models showed that children with trajectories of high WC, %FM and FMI during childhood were related with earlier thelarche, pubarche, menarche and PHV; BMI trajectories only with menarche and PHV.

Conclusions: Higher WC, %FM and FMI were associated with earlier age at thelarche, pubarche, menarche, and PHV. The effect of BMI was less consistent.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche},

author = {Ana Pereira},

doi = {doi: 10.1080/15592294.2023.2200366},

year  = {2023},

date = {2023-05-08},

urldate = {2023-05-08},

journal = {Epigenetics},

abstract = {- Otros autores: Ponce D, Rodríguez F, Miranda JP, Binder AM, Santos JL, Michels KB, Cutler GB, Iñiquez G, Mericq V. 

 

- Cómo citar: Ponce D, Rodríguez F, Miranda JP, Binder AM, Santos JL, Michels KB, Cutler GB, Pereira A, Iñiquez G, Mericq V. Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche. Epigenetics. 2023;18(1):2200366. doi: 10.1080/15592294.2023.2200366. PMID: 37053179. ISSN: 1559-2294. IF [JCR]: 3.7. Q2



 - Resumen: Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown. Epigenetic modifications, and specifically DNA methylation, have been associated with the initiation and progression of numerous disorders, including obesity and insulin resistance. The aim of this study was to determine if prepubertal androgen exposure is associated with a different methylation profile in pubertal girls. Eighty-six healthy girls were studied. At age 7 y, anthropometric measurements were begun and DHEAS levels were determined. Girls were classified into Low DHEAS (LD) [<42 μg/dL] and High DHEAS (HD) [≥42 μg/dL] groups. At Tanner stages 2 and 4 a DNA methylation microarray was performed to identify differentially methylated CpG positions (DMPs) between HD and LD groups. We observed a differential methylation pattern between pubertal girls with and without biochemical PA. Moreover, a set of DNA methylation markers, selected by the LASSO method, successfully distinguished between HD and LD girls regardless of Tanner stage. Additionally, a subset of these markers were significantly associated with glucose-related measures such as insulin level, HOMA-IR, and glycaemia. This pilot study provides evidence consistent with the hypothesis that high DHEAS concentration, or its hormonally active metabolites, may induce a unique blood methylation signature in pubertal girls, and that this methylation pattern is associated with altered glucose metabolism.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Assessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages},

author = {Ana Pereira and Marcela Reyes and Camila Corvalán},

doi = {doi: 10.1038/s41598-022-25771-5},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {Sci Rep.},

abstract = {- Otros autores: Espejo JP, Mericq V, Cifuentes M. 

 

- Cómo citar: Pereira A, Reyes M, Corvalán C, Espejo JP, Mericq V, Cifuentes M. Assessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages. Sci Rep. 2022;12:21129. doi: 10.1038/s41598-022-25771-5. PMID: 36477173. ISSN: 2045-2322. IF [JCR]: 4.997. Q1



 - Resumen: Not all individuals with obesity develop metabolic complications, which has brought about the concepts of metabolically healthy and unhealthy obesity (MHO/MUO). However, inconsistent definitions of these conditions have limited their understanding. We assessed whether a recently-proposed consensus definition for MHO/MUO correlates with adiposity and reflects metabolic risk parameters during puberty. Low-middle income children from the Growth and Obesity Cohort Study (Santiago, Chile) were included (n = 949; 1692 visits at Tanner (T)2, T4 and/or one-year post menarche (1YPM)). Anthropometry, body composition and metabolic parameters were compared between MUO and MHO, and also in children without obesity. The risk for presenting MUO phenotype was significantly elevated with higher waist-height ratio (T2), zBMI (T2, T4), trunk fat, and C-reactive protein (T4). Elevated cardiometabolic indices were important predictors of the “unhealthy” phenotype allocation in children with or without obesity. Our observations suggest that the consensus definition in children at T2, T4 and 1YPM reflects metabolic risk and central obesity. Metabolic health phenotype allocation by this equation enables easy detection of risk factors that call for action to prevent long-term metabolic derangements in children with obesity and, importantly, also those without obesity.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Dietary Iron Intake in Relation to Age of Menarche: A Perspective Cohort Study in Chilean Girls},

author = {Ana Pereira and Camila Corvalán},

doi = {doi: 10.1016/j.tjnut.2022.10.002 },

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {Journal of Nutrition},

abstract = {- Otros autores: Ekwuocha I, Michels KB, Gaskins AJ.

 

- Cómo citar: Ekwuocha I, Pereira A, Corvalán C, Michels KB, Gaskins AJ. Dietary Iron Intake in Relation to Age of Menarche: A Perspective Cohort Study in Chilean Girls. J. Nutr. 2022;Preprint. doi: 10.1016/j.tjnut.2022.10.002. ISSN: 0022-3166. IF [JCR]: 4.735. Q1 



 - Resumen: This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (rpartial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (rpartial = 0.46, p-value = 0.003), but not in mothers (rpartial = 0.17, p-value = 0.32). In mothers, %FGV from DXA was associated with %MBD from mammograms (rpartial = 0.60, p-value < 0.001). These findings suggest that data from OS, DXA, and mammograms provide related but distinct information about breast density and BTC. Future studies should explore how the information provided by these different devices can be used for breast cancer risk prediction in cohorts of adolescent girls and women.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Early Childhood Development policy in Chile: Progress and pitfalls supporting children with developmental disabilities toward school readiness},

author = {Miguel Cordero},

doi = {doi:10.3389/fpubh.2022.983513},

issn = {2296-2565},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

abstract = {- Otros autores:  Breinbauer C, Vidal V, Molina P, Trabucco C, Gutierrez L. 

 

- Cómo citar: Breinbauer C, Vidal V, Molina P, Trabucco C, Gutierrez L, Cordero M. Early Childhood Development policy in Chile: Progress and pitfalls supporting children with developmental disabilities toward school readiness. Front. Public Health. 2022;10. doi:10.3389/fpubh.2022.983513. PMID: 36311641 PMCID: PMC9597457. ISSN: 2296-2565. IF [JCR]: 6.461. Q1



 - Resumen: There is now evidence indicating that first 5 years of life are of major importance for learning and health across life course (1, 2). This period is key in providing detection and timely supports for children with developmental disabilities (3, 4). Because of this, many investments have been done around the world (5). Specifically for this article, we illustrate the case of Chile. This paper provides an overview of some investments in public health, social protection, and education that Chile has done in supporting children with developmental disabilities during early childhood. The authors also provide their opinion about progress as well as barriers affecting school readiness for children with developmental disabilities during the last decade.



},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_74,

title = {Genome-Wide Association Study And Polygenic Risk Scores Of Serum Dheas Levels In A Chilean Children Cohort.},

author = {Camila Corvalán and Ana Pereira},

doi = {10.1210/clinem/dgab814},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {J Clin Endocrinol Metab.},

abstract = {- Otros autores: Miranda JP, Lardone MC, Rodríguez F, Cutler GB Jr, Santos JL, Mericq V. 

 

- Cómo citar: Miranda JP, Lardone MC, Rodríguez F, Cutler GB Jr, Santos JL, Mericq V. Genome-Wide Association Study And Polygenic Risk Scores Of Serum Dheas Levels In A Chilean Children Cohort. J Clin Endocrinol Metab. 2022;107(4):e1727-e1738 doi: 10.1210/clinem/dgab814. PMID: 34748635. ISSN: 0021-972X. IF [JCR]: 6.134. Q1 

 

-Resumen: "Context: Adrenarche reflects the developmental growth of the adrenal zona reticularis, which produces increasing adrenal androgen secretion (eg, dehydroepiandrosterone [DHEA]/dehydroepiandrosterone sulfate [DHEAS]) from approximately age 5 to 15 years. 

Objective: We hypothesized that the study of the genetic determinants associated with variations in serum DHEAS during adrenarche might detect genetic variants influencing the rate or timing of this process. Methods: Genome-wide genotyping was performed in participants of the Chilean pediatric Growth and Obesity Chilean Cohort Study (GOCS) cohort (n = 788). We evaluated the genetic determinants of DHEAS levels at the genome-wide level and in targeted genes associated with steroidogenesis. To corroborate our findings, we evaluated a polygenic risk score (PRS) for age at pubarche, based on the discovered variants, in children from the same cohort. Results: We identified one significant variant at the genome-wide level in the full cohort, close to the GALR1 gene (P = 3.81 × 10-8). In addition, variants suggestive of association (P < 1 × 10-5) were observed in PRLR, PITX1, PTPRD, NR1H4, and BCL11B. Stratifying by sex, we found variants suggestive of association in SERBP1 and CAMTA1/VAMP3 for boys and near ZNF98, TRPC6, and SULT2A1 for girls. We also found significant reductions in age at pubarche in those children with higher PRS for greater DHEAS based on these newly identified variants. 

Conclusion: Our results disclose one variant associated with DHEAS concentrations at the level of genome-wide association study significance, and several variants with a suggestive association that may be involved in the genetic regulation of adrenarche."},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_73,

title = {High DHEAS in girls and metabolic features throughout pubertal maturation.},

author = {Camila Corvalán and Ana Pereira},

doi = {10.1111/cen.14654},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {Clin. Endocrinol.},

abstract = {- Otros autores: Merino PM, Santos JL, Iñiguez G, Cutler Jr. GB, Mericq V. 

 

- Cómo citar:Merino PM, Santos JL, Iñiguez G, Cutler Jr. GB, Mericq V. High DHEAS in girls and metabolic features throughout pubertal maturation. Clin. Endocrinol. 2022;96(3):419-427. doi: 10.1111/cen.14654. PMID: 34904249. ISSN: 0300-0664. IF [JCR]: 3.523. Q3 

 

-Resumen: "Context: An association between premature adrenarche and metabolic syndrome at presentation has been described. Our aim was to assess whether the presence of high dehydroepiandrosterone sulphate (DHEAS [HD]) at the adrenarche determines the risk of metabolic syndrome during puberty, taking into account body mass index (BMI) and birth weight. 

Design: Prospective observational. 

Patients: Five hundred four girls from the Growth and Obesity Chilean Cohort Study were followed from birth through puberty. At age ~7, subjects were classified by DHEAS concentrations into the HD (>75th percentile) or normal DHEAS (ND, ≤75th percentile) subgroups. 

Measurements: Anthropometrics, semiannual clinical pubertal staging and hormonal and metabolic levels. The relationships among DHEAS at age ~7, metabolic syndrome, and each of its components independently, were analyzed by linear and logistic regression models during puberty and 1-year postmenarche, adjusted by confounders. 

Results: Girls with HD at 7 years exhibited higher BMI, more central fat and higher serum androgen and insulin like growth factor (IGF)-I levels throughout puberty. Also, girls with HD had a greater prevalence of hyperglycemia at B2 and B4 breast stages, and of low HDL at B4. At 1 year after menarche, HD girls had a higher prevalence of metabolic syndrome, and those with BMI > 1 SD score had a higher metabolic score and insulin levels than ND girls with similar BMI. 

Conclusions: Our observations suggest that girls with HD at the age of adrenarche may be at greater risk for metabolic syndrome at adolescence, especially in those who are overweight or obese. Our results emphasize the importance of lifestyle interventions for childhood overweight and obesity among girls with HD."},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Higher prepubertal IGF-1 concentrations associate to earlier pubertal tempo in both sexes},

author = {Ana Pereira and Pedro Ferrer},

doi = {doi: 10.1159/000528662},

year  = {2022},

date = {2022-00-00},

urldate = {2022-00-00},

journal = {Horm. Res. Paediatr.},

abstract = {- Otros autores: Baier I, Iñiguez G, Mericq V.

 

- Cómo citar: Baier I, Pereira A, Ferrer P, Iñiguez G, Mericq V. Higher prepubertal IGF-1 concentrations associate to earlier pubertal tempo in both sexes. Horm. Res. Paediatr. 2022;Preprint. doi: 10.1159/000528662. PMID: 36513037. ISSN: 1663-2818. IF [JCR]: 4.275. Q1



 - Resumen: Introduction: Pubertal onset is triggered by multiple neuroendocrine interactions. The role of prepubertal IGF-1 in this process has not been explored in both sexes. Our objective is to analyze the association of prepubertal IGF-1 concentration with age at thelarche (B2) and menarche (M) in girls and age at gonadarche (G2) in boys. Methods: Longitudinal study (n=1196 boys and girls) within the Growth and Obesity Chilean cohort Study (GOCS). At ages ≈ 6.7 years blood sample for IGF-1. Subjects analyzed into 4 groups according to the onset age of the pubertal event.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_76,

title = {Anthropometric and bioimpedance equations for fat and fat-free mass in Chilean children 7-9 years of age.},

author = {Camila Corvalán},

doi = {10.1017/S0007114520003906},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Br. J. Nutr.},

abstract = {- Otros autores: Salazar G, Leighton B, Aguirre C, Anziani A, Weisstaub G. 

 

- Cómo citar: Salazar G, Leighton B, Aguirre C, Anziani A, Weisstaub G. Anthropometric and bioimpedance equations for fat and fat-free mass in Chilean children 7-9 years of age. Br. J. Nutr. 2021; 126(1):37-42. doi: 10.1017/S0007114520003906. PMID: 33028443. ISSN: 007-1145. IF [JCR]: 4.125. Q3 

 -Resumen: Assessing children's growth adequately is important due to the necessary prevention of adequate body composition, especially at pre-pubertal age. Simpler measurements such as anthropometry or bioimpedance, using equations validated in Caucasian children, have been demonstrated to overestimate or underestimate fat mass percentage (FM%) or fat-free mass (FFM) in Chilean children. In a sample of 424 children (198 boys and 226 girls) of 7-9 years old, the three component (3C) model was assessed, where total body water was determined by 2H dilution and body volume by air displacement plethysmography, in order to design and validate anthropometry and bioimpedance equations. The FM (%) equation specific for Chilean children was validated as (1·743 × BMI z-score) + (0·727 × triceps skinfold) + (0·385 × biceps skinfold) + 15·985, against the 3C model (R2 0·79). The new FFM equation (kg) generated was (log FFM = (0·018 × age) + (0·047 × sex) + (0·006 × weight) + (0·027 × resistance) + 2·071), with an R2 0·93 (female = 1 and male = 2). The Bland-Altman analysis shows a mean difference of 0·27 (sd 3·5) for the FM% in the whole group as well as 0·004 (sd 0·9) kg is the mean difference for the bioelectrical impedance analysis (BIA) FFM (kg) equation. The new equations for FM (%) and FFM (kg) in Chilean children will provide a simple and valid tool for the assessment of body composition in cohort studies or to assess the impact of nutritional programmes or public policies.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_91,

title = {Association between obesity with pattern and length of menstrual cycle: The role of metabolic and hormonal markers.},

author = {María Luisa Garmendia and Ana Pereira},

doi = {10.1016/j.ejogrb.2021.02.021},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Eur. J. Obstet. Gynecol. Reprod. Biol.},

abstract = {- Otros autores: Roman Lay A. 

 

- Cómo citar: Roman Lay A. Association between obesity with pattern and length of menstrual cycle: The role of metabolic and hormonal markers. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021;260:225-231. doi: 10.1016/j.ejogrb.2021.02.021. PMID: 33741219. ISSN: 0301-2115. IF [JCR]: 2.831. Q3 

 

-Resumen: "Objectives: To evaluate in a sample of Chilean adult women, the association between adiposity markers with pattern and length of the menstrual cycle, assessing the influence of metabolic markers and hormones in this relationship. 

Study design: We conducted a cross-sectional study involving 401 premenopausal women belonging to the DERCAM study (Determinants of Breast Cancer Risk) from Santiago, Chile. The menstrual cycle pattern was defined as regular or irregular, while menstrual cycle length was categorized as short (≤25 d), normal (26–31d), and long (≥32d). Adiposity markers included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and body fat percentage (BFP). Insulin, sex-hormone-binding globulin (SHBG), estrone (E1), estradiol (E2), androstenedione (A2), follicle-stimulating hormone (FSH) and progesterone were measured in the follicular phase of the menstrual cycle. Results: There was no association between adiposity markers and cycle patterns. However, after all, metabolic and hormonal adjustments, women in the third tertile of BFP (RRR = 2.63; 95 % CI: 1.21.5.69) were more likely to have longer menstrual cycles. 

Conclusion: Women with high BFP presented a higher risk of having irregular menstrual cycles, which was an indicator of reproductive disorders; this relationship could be partially mediated by hormonal markers, especially SHBG, E1, and insulin levels."},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_85,

title = {Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective.},

author = {Ana Pereira and Camila Corvalán},

doi = {10.1111/obr.13245},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Obes. Rev.},

abstract = {- Otros autores: Perng W, Cantoral A, Soria-Contreras DC, Betanzos-Robledo L, Kordas K, Liu Y, Mora AM, Cardoso MA, Chavarro JE, Breton CV, Meeker JD, Harley KG, Eskenazi B, Peterson KE, Tellez-Rojo MM. 

 

- Cómo citar: Perng W, Cantoral A, Soria-Contreras DC, Betanzos-Robledo L, Kordas K, Liu Y, Mora AM, Cardoso MA, Chavarro JE, Breton CV, Meeker JD, Harley KG, Eskenazi B, Peterson KE, Tellez-Rojo MM. Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective. Obes. Rev. 2021;22(S3):e13245. doi: 10.1111/obr.13245. PMID: 33951277. ISSN:1467-789X. IF [JCR]: 10.867. Q1 

 

-Resumen: Following a 2019 workshop led by the Center for Global Health Studies at the Fogarty International Center on the topic of childhood obesity prevention and research synergies transpiring from cross-border collaborations, we convened a group of experts in the United States and Latin America to conduct a narrative review of the epidemiological literature on the role of obesogenic endocrine disrupting chemicals (EDCs) in the etiology of childhood obesity among Latino youth in the United States and Latin America. In addition to summarizing and synthesizing results from research on this topic published within the last decade, we place the findings within a lifecourse biobehavioral framework to aid in identification of unique exposure-outcome relationships driven by both biological and behavioral research, identify inconsistencies and deficiencies in current literature, and discuss the role of policy regulations, all with the goal of identifying viable avenues for prevention of early life obesity in Latino/Hispanic populations.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_84,

title = {Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys.},

author = {Ana Pereira},

doi = {10.1007/s00439-021-02290-3},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {Hum. Genet.},

abstract = {- Otros autores: Vicuña L, Norambuena T, Miranda JP, Mericq V, Ongaro L, Montinaro F, Santos JL, Eyheramendy S. 

 

- Cómo citar: Vicuña L, Norambuena T, Miranda JP, Mericq V, Ongaro L, Montinaro F, Santos JL, Eyheramendy S. Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys. Hum. Genet. 2021;140:1651-1661. doi: 10.1007/s00439-021-02290-3. PMID: 34047840. ISSN: 0340-6717. IF [JCR]: 5.881. Q1 

 -Resumen: Puberty is a complex developmental process that varies considerably among individuals and populations. Genetic factors explain a large proportion of the variability of several pubertal traits. Recent genome-wide association studies (GWAS) have identified hundreds of variants involved in traits that result from body growth, like adult height. However, they do not capture many genetic loci involved in growth changes over distinct growth phases. Further, such GWAS have been mostly performed in Europeans, but it is unknown how these findings relate to other continental populations. In this study, we analyzed the genetic basis of three pubertal traits; namely, peak height velocity (PV), age at PV (APV) and height at APV (HAPV). We analyzed a cohort of 904 admixed Chilean children and adolescents with European and Mapuche Native American ancestries. Height was measured on roughly a [Formula: see text]month basis from childhood to adolescence between 2006 and 2019. We predict that, in average, HAPV is 4.3 cm higher in European than in Mapuche adolescents (P = 0.042), and APV is 0.73 years later in European compared with Mapuche adolescents (P = 0.023). Further, by performing a GWAS on 774, 433 single-nucleotide polymorphisms, we identified a genetic signal harboring 3 linked variants significantly associated with PV in boys (P [Formula: see text]). This signal has never been associated with growth-related traits.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}

@article{nokey_86,

title = {Total and central adiposity are associated with age at gonadarche and incidence of precocious gonadarche in boys.},

author = {Ana Pereira and Camila Corvalán},

doi = {10.1210/clinem/dgab064},

year  = {2021},

date = {2021-00-00},

urldate = {2021-00-00},

journal = {J. Clin. Endocrinol. Metab.},

abstract = {- Otros autores: Busch AS, Solares F, Baier I, Mericq V. 

 

- Cómo citar: Busch AS, Solares F, Baier I, Mericq V. Total and central adiposity are associated with age at gonadarche and incidence of precocious gonadarche in boys. J. Clin. Endocrinol. Metab. 2021;106(5):1352-1361. doi: 10.1210/clinem/dgab064. PMID: 33539513. ISSN:0021-972X. IF [JCR]: 6.134. Q1 

 

-Resumen: Context: A close link between body mass index (BMI) and female pubertal onset is well established. However, observations in boys remain inconclusive. 

Objective: We aim to determine whether BMI as well as total and central adiposity in prepubertal Chilean boys is associated with pubertal timing. 

Methods: We performed a longitudinal study in which 494 boys from the Growth and Obesity Chilean Cohort Study were followed starting from birth and throughout puberty, including 5 prepubertal visits. The main outcome measures included anthropometric data and semi-annual clinical pubertal staging. The association between BMI, obesity (BMI standard deviation score [SDS] ≥ 2) and central adiposity (waist circumference ≥ 90th centile) with precocious puberty and age at gonadarche was analyzed using survival- and logistic regression models. 

Results: BMI, prevalence of total obesity, and central obesity increased throughout childhood. Among the study population, 45 boys entered puberty before the age of 9 years (9.1%). Obesity at 4 to 7 years and childhood mean BMI SDS were significantly associated with precocious gonadarche. Mean age at testicular enlargement (≥4 mL), was 11.0 years (95% CI, 10.9-11.1) and was inversely associated with BMI SDS, waist circumference, and percentage fat mass in almost all prepubertal visits. Age at testicular enlargement in normal weight, overweight, and obese boys was 11.2 (11.0-11.3), 10.9 (10.6-11.1) and 10.7 (10.4-11.1) years, respectively. 

Conclusion: Our observation supports the association of BMI SDS and obesity with pubertal timing and precocious gonadarche in boys, respectively. Early intervention controlling the obesity epidemic could be useful in decreasing detrimental impact on later health.},

keywords = {   L3: Ventanas Críticas del Desarrollo: Adolescencia.    /   },

pubstate = {published},

tppubtype = {article}

}