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2023
Mujica, Fernanda; Garmendia, María Luisa; Corvalán, Camila
Iron, folic acid, and vitamin D supplementation during pregnancy: Did pregnant Chilean women meet the recommendations during the COVID pandemic? Artículo de revista
En: PLoS One., 2023.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {Iron, folic acid, and vitamin D supplementation during pregnancy: Did pregnant Chilean women meet the recommendations during the COVID pandemic?},
author = {Fernanda Mujica and María Luisa Garmendia and Camila Corvalán},
doi = {10.1371/journal.pone.0293745},
year = {2023},
date = {2023-12-04},
urldate = {2023-12-04},
journal = {PLoS One.},
abstract = {- Otros autores: Mujica-Coopman, M. F., Garmendia, M. L., & Corvalán, C.
- Cómo citar: Mujica-Coopman, M. F., Garmendia, M. L., & Corvalán, C. (2023). Iron, folic acid, and vitamin D supplementation during pregnancy: Did pregnant Chilean women meet the recommendations during the COVID pandemic?. PloS one, 18(11), e0293745. https://doi.org/10.1371/journal.pone.0293745.
- Resumen: Background: Antenatal micronutrient supplementation has been defined as a priority for Low-and Middle-income Countries (LMICs). However, it is also relevant to assess its performance in middle-high income countries, such as Chile, particularly given the post-pandemic food insecurity context.
Aim: To assess the use (frequency and doses) of daily recommended supplementation (iron (15-30 mg), folic acid (FA) (400-800 μg/day), and vitamin (VD) (400 IU)) in a sample of Chilean pregnant women.
Methods: In 1, 507 pregnant women selected from public health care registries of the Southeast area of Santiago-Chile, we collected maternal, supplement use, sociodemographic, and nutritional information at the first (<15 weeks), second (24-28 weeks), and third trimesters (32-36 weeks) of gestation by using a researcher administer online questionnaire.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Mujica-Coopman, M. F., Garmendia, M. L., & Corvalán, C.
- Cómo citar: Mujica-Coopman, M. F., Garmendia, M. L., & Corvalán, C. (2023). Iron, folic acid, and vitamin D supplementation during pregnancy: Did pregnant Chilean women meet the recommendations during the COVID pandemic?. PloS one, 18(11), e0293745. https://doi.org/10.1371/journal.pone.0293745.
- Resumen: Background: Antenatal micronutrient supplementation has been defined as a priority for Low-and Middle-income Countries (LMICs). However, it is also relevant to assess its performance in middle-high income countries, such as Chile, particularly given the post-pandemic food insecurity context.
Aim: To assess the use (frequency and doses) of daily recommended supplementation (iron (15-30 mg), folic acid (FA) (400-800 μg/day), and vitamin (VD) (400 IU)) in a sample of Chilean pregnant women.
Methods: In 1, 507 pregnant women selected from public health care registries of the Southeast area of Santiago-Chile, we collected maternal, supplement use, sociodemographic, and nutritional information at the first (<15 weeks), second (24-28 weeks), and third trimesters (32-36 weeks) of gestation by using a researcher administer online questionnaire.
- Cómo citar: Mujica-Coopman, M. F., Garmendia, M. L., & Corvalán, C. (2023). Iron, folic acid, and vitamin D supplementation during pregnancy: Did pregnant Chilean women meet the recommendations during the COVID pandemic?. PloS one, 18(11), e0293745. https://doi.org/10.1371/journal.pone.0293745.
- Resumen: Background: Antenatal micronutrient supplementation has been defined as a priority for Low-and Middle-income Countries (LMICs). However, it is also relevant to assess its performance in middle-high income countries, such as Chile, particularly given the post-pandemic food insecurity context.
Aim: To assess the use (frequency and doses) of daily recommended supplementation (iron (15-30 mg), folic acid (FA) (400-800 μg/day), and vitamin (VD) (400 IU)) in a sample of Chilean pregnant women.
Methods: In 1, 507 pregnant women selected from public health care registries of the Southeast area of Santiago-Chile, we collected maternal, supplement use, sociodemographic, and nutritional information at the first (<15 weeks), second (24-28 weeks), and third trimesters (32-36 weeks) of gestation by using a researcher administer online questionnaire.
Garmendia, María Luisa
The impact of health policies and the COVID-19 pandemic on exclusive breastfeeding in Chile during 2009–2020 Artículo de revista
En: Sci Rep., 2023.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {The impact of health policies and the COVID-19 pandemic on exclusive breastfeeding in Chile during 2009–2020},
author = {María Luisa Garmendia },
doi = {10.1038/s41598-023-37675-z},
year = {2023},
date = {2023-08-14},
urldate = {2023-08-14},
journal = {Sci Rep.},
abstract = {- Otros autores: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez Arana S, Rodriguez-Osiac L.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez Arana S, Rodriguez-Osiac L, Garmendia ML. The impact of health policies and the COVID-19 pandemic on exclusive breastfeeding in Chile during 2009–2020. Sci Rep. 2023;13(1):10671. doi: 10.1038/s41598-023-37675-z. PMID: 37393366. PMCID: PMC10314914. ISSN: 2045-2322. IF [JCR]: 4.6. Q2
- Resumen: In 2011, Chile added 12 mandatory extra weeks of maternity leave (ML). In January 2015, a pay-for-performance (P4P) strategy was included in the primary healthcare system, incorporating exclusive breastfeeding (EBF) promotion actions. The COVID-19 pandemic led to healthcare access difficulties and augmented household workloads. Our aim was to evaluate the effect of a 24-week ML, the P4P strategy, and COVID-19 on EBF prevalence, at 3 and 6 months in Chile. Aggregated EBF prevalence data from public healthcare users nationwide (80% of the Chilean population) was collected by month. Interrupted time series analyses were used to quantify changes in EBF trends from 2009 to 2020. The heterogeneity of EBF changes was assessed by urban/setting and across geographic settings. We found no effect of ML on EBF; the P4P strategy increased EBF at 3 months by 3.1% and 5.7% at 6 months. COVID-19 reduced EBF at 3 months by - 4.5%. Geographical heterogeneity in the impact of the two policies and COVID-19 on EBF was identified. The null effect of ML on EBF in the public healthcare system could be explained by low access from public healthcare users to ML (20% had access to ML) and by an insufficient ML duration (five and a half months). The negative impact of COVID-19 on EBF should alert policy makers about the crisis's effect on health promotion activities.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez Arana S, Rodriguez-Osiac L.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez Arana S, Rodriguez-Osiac L, Garmendia ML. The impact of health policies and the COVID-19 pandemic on exclusive breastfeeding in Chile during 2009–2020. Sci Rep. 2023;13(1):10671. doi: 10.1038/s41598-023-37675-z. PMID: 37393366. PMCID: PMC10314914. ISSN: 2045-2322. IF [JCR]: 4.6. Q2
- Resumen: In 2011, Chile added 12 mandatory extra weeks of maternity leave (ML). In January 2015, a pay-for-performance (P4P) strategy was included in the primary healthcare system, incorporating exclusive breastfeeding (EBF) promotion actions. The COVID-19 pandemic led to healthcare access difficulties and augmented household workloads. Our aim was to evaluate the effect of a 24-week ML, the P4P strategy, and COVID-19 on EBF prevalence, at 3 and 6 months in Chile. Aggregated EBF prevalence data from public healthcare users nationwide (80% of the Chilean population) was collected by month. Interrupted time series analyses were used to quantify changes in EBF trends from 2009 to 2020. The heterogeneity of EBF changes was assessed by urban/setting and across geographic settings. We found no effect of ML on EBF; the P4P strategy increased EBF at 3 months by 3.1% and 5.7% at 6 months. COVID-19 reduced EBF at 3 months by - 4.5%. Geographical heterogeneity in the impact of the two policies and COVID-19 on EBF was identified. The null effect of ML on EBF in the public healthcare system could be explained by low access from public healthcare users to ML (20% had access to ML) and by an insufficient ML duration (five and a half months). The negative impact of COVID-19 on EBF should alert policy makers about the crisis's effect on health promotion activities.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez Arana S, Rodriguez-Osiac L, Garmendia ML. The impact of health policies and the COVID-19 pandemic on exclusive breastfeeding in Chile during 2009–2020. Sci Rep. 2023;13(1):10671. doi: 10.1038/s41598-023-37675-z. PMID: 37393366. PMCID: PMC10314914. ISSN: 2045-2322. IF [JCR]: 4.6. Q2
- Resumen: In 2011, Chile added 12 mandatory extra weeks of maternity leave (ML). In January 2015, a pay-for-performance (P4P) strategy was included in the primary healthcare system, incorporating exclusive breastfeeding (EBF) promotion actions. The COVID-19 pandemic led to healthcare access difficulties and augmented household workloads. Our aim was to evaluate the effect of a 24-week ML, the P4P strategy, and COVID-19 on EBF prevalence, at 3 and 6 months in Chile. Aggregated EBF prevalence data from public healthcare users nationwide (80% of the Chilean population) was collected by month. Interrupted time series analyses were used to quantify changes in EBF trends from 2009 to 2020. The heterogeneity of EBF changes was assessed by urban/setting and across geographic settings. We found no effect of ML on EBF; the P4P strategy increased EBF at 3 months by 3.1% and 5.7% at 6 months. COVID-19 reduced EBF at 3 months by - 4.5%. Geographical heterogeneity in the impact of the two policies and COVID-19 on EBF was identified. The null effect of ML on EBF in the public healthcare system could be explained by low access from public healthcare users to ML (20% had access to ML) and by an insufficient ML duration (five and a half months). The negative impact of COVID-19 on EBF should alert policy makers about the crisis's effect on health promotion activities.
Pereira, Ana
New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry Artículo de revista
En: iScience, 2023.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry},
author = {Ana Pereira},
doi = {10.1016/j.isci.2023.106091},
year = {2023},
date = {2023-03-13},
urldate = {2023-03-13},
journal = {iScience},
abstract = {- Otros autores: Vicuña L, Barrientos E, Norambiena T, Alvares D, Gana JC, Leiva-Yamaguchi V, Meza C, Santos JL, Meriq V, Eyheramendy S.
- Cómo citar: Vicuña L, Barrientos E, Norambiena T, Alvares D, Gana JC, Leiva-Yamaguchi V, Meza C, Santos JL, Meriq V, Pereira A, Eyheramendy S. New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry. iScience. 2023; 26:106091. doi: 10.1016/j.isci.2023.106091. PMID: 36844456. EISSN: 2589-0042. IF [JCR]: 5.8. Q1
- Resumen: Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 −2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P=9.8×10−9). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P=0.004) by 1.94 years and BMI at AR was significantly higher (P=0.04) by 1.2 kg/ m2, in Mapuche children compared with Europeans.
Keywords: Genomics; Health sciences; Human genetics.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Vicuña L, Barrientos E, Norambiena T, Alvares D, Gana JC, Leiva-Yamaguchi V, Meza C, Santos JL, Meriq V, Eyheramendy S.
- Cómo citar: Vicuña L, Barrientos E, Norambiena T, Alvares D, Gana JC, Leiva-Yamaguchi V, Meza C, Santos JL, Meriq V, Pereira A, Eyheramendy S. New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry. iScience. 2023; 26:106091. doi: 10.1016/j.isci.2023.106091. PMID: 36844456. EISSN: 2589-0042. IF [JCR]: 5.8. Q1
- Resumen: Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 −2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P=9.8×10−9). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P=0.004) by 1.94 years and BMI at AR was significantly higher (P=0.04) by 1.2 kg/ m2, in Mapuche children compared with Europeans.
Keywords: Genomics; Health sciences; Human genetics.
- Cómo citar: Vicuña L, Barrientos E, Norambiena T, Alvares D, Gana JC, Leiva-Yamaguchi V, Meza C, Santos JL, Meriq V, Pereira A, Eyheramendy S. New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry. iScience. 2023; 26:106091. doi: 10.1016/j.isci.2023.106091. PMID: 36844456. EISSN: 2589-0042. IF [JCR]: 5.8. Q1
- Resumen: Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 −2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P=9.8×10−9). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P=0.004) by 1.94 years and BMI at AR was significantly higher (P=0.04) by 1.2 kg/ m2, in Mapuche children compared with Europeans.
Keywords: Genomics; Health sciences; Human genetics.
2022
Toro, Rosario
Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT. Artículo de revista
En: Nutrition, 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_59,
title = {Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT.},
author = {Rosario Toro},
doi = {10.1016/j.nut.2022.111599},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Nutrition},
abstract = {- Otros autores: Jaramillo-Ospina AM, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R.
- Cómo citar: Jaramillo-Ospina AM, Toro-Campos R, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R. Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT. Nutrition. 2022; 97:111599. doi: 10.1016/j.nut.2022.111599. PMID: 35193081. ISSN: 0899-9007. IF [JCR]: 4.893. Q2
- Resumen: "Objective: The aim of this study was to assess the effects of an experimental formula (EF) with added whey protein-lipid concentrate (5 g/L; source of bovine milk fat globule membrane [bMFGM]) on growth, body composition, and safety through 24 mo of age in term infants.
Methods: This was a double-blinded, randomized controlled trial conducted in Santiago, Chile. Infants were enrolled before 120 d and randomized to receive standard cow's milk-based formula (SF) or EF through the first year of life. Breastfed infants were the reference (HM). Growth (weight-for-age [WAZ], length-for-age [LAZ], BMI-for-age [BAZ], headcircumference-for-age [HCZ] z-scores); body composition (fat mass [FM] and fat-free mass, percentage body fat [%BF]); and adverse events through day 730 were recorded. Outcome trajectories were analyzed using a single generalized estimating equation testing the interaction between group and visit. Results: We recruited 582 infants (HM = 235; SF = 174; EF = 173); 478 (>80%) completed the study. At baseline, only WAZ was different between the formula groups (0.14 lower in EF versus SF group},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Jaramillo-Ospina AM, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R.
- Cómo citar: Jaramillo-Ospina AM, Toro-Campos R, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R. Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT. Nutrition. 2022; 97:111599. doi: 10.1016/j.nut.2022.111599. PMID: 35193081. ISSN: 0899-9007. IF [JCR]: 4.893. Q2
- Resumen: "Objective: The aim of this study was to assess the effects of an experimental formula (EF) with added whey protein-lipid concentrate (5 g/L; source of bovine milk fat globule membrane [bMFGM]) on growth, body composition, and safety through 24 mo of age in term infants.
Methods: This was a double-blinded, randomized controlled trial conducted in Santiago, Chile. Infants were enrolled before 120 d and randomized to receive standard cow's milk-based formula (SF) or EF through the first year of life. Breastfed infants were the reference (HM). Growth (weight-for-age [WAZ], length-for-age [LAZ], BMI-for-age [BAZ], headcircumference-for-age [HCZ] z-scores); body composition (fat mass [FM] and fat-free mass, percentage body fat [%BF]); and adverse events through day 730 were recorded. Outcome trajectories were analyzed using a single generalized estimating equation testing the interaction between group and visit. Results: We recruited 582 infants (HM = 235; SF = 174; EF = 173); 478 (>80%) completed the study. At baseline, only WAZ was different between the formula groups (0.14 lower in EF versus SF group
- Cómo citar: Jaramillo-Ospina AM, Toro-Campos R, Murguia-Peniche T, Wampler JL, Wu SS, Berseth CL, Uauy R. Added bovine milk fat globule membrane in formula--Growth, body composition and safety through age two: an RCT. Nutrition. 2022; 97:111599. doi: 10.1016/j.nut.2022.111599. PMID: 35193081. ISSN: 0899-9007. IF [JCR]: 4.893. Q2
- Resumen: "Objective: The aim of this study was to assess the effects of an experimental formula (EF) with added whey protein-lipid concentrate (5 g/L; source of bovine milk fat globule membrane [bMFGM]) on growth, body composition, and safety through 24 mo of age in term infants.
Methods: This was a double-blinded, randomized controlled trial conducted in Santiago, Chile. Infants were enrolled before 120 d and randomized to receive standard cow's milk-based formula (SF) or EF through the first year of life. Breastfed infants were the reference (HM). Growth (weight-for-age [WAZ], length-for-age [LAZ], BMI-for-age [BAZ], headcircumference-for-age [HCZ] z-scores); body composition (fat mass [FM] and fat-free mass, percentage body fat [%BF]); and adverse events through day 730 were recorded. Outcome trajectories were analyzed using a single generalized estimating equation testing the interaction between group and visit. Results: We recruited 582 infants (HM = 235; SF = 174; EF = 173); 478 (>80%) completed the study. At baseline, only WAZ was different between the formula groups (0.14 lower in EF versus SF group
Garmendia, María Luisa
Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behavior, and body composition in children. Artículo de revista
En: Int. J. Obes., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_56,
title = {Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behavior, and body composition in children.},
author = {María Luisa Garmendia},
doi = {10.1038/s41366-022-01067-6},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Int. J. Obes.},
abstract = {- Otros autores: Jaramillo A, Casanello P, Andersen R, Levitan R, Meaney M, Silveira PP.
- Cómo citar: Jaramillo A, Casanello P, Andersen R, Levitan R, Meaney M, Silveira PP. Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behavior, and body composition in children. Int. J. Obes. 2022; 46:977–985. doi: 10.1038/s41366-022-01067-6. PMID: 35058573. ISSN: 0307-0565. IF [JCR]: 5.551. Q2
- Resumen: "Background: The relationship between eating behaviour and current body weight has been described. However little is known about the effect of polyunsaturated fatty acids (PUFA) in this relationship. Genetic contribution to a certain condition is derived from a combination of small effects from many genetic variants, and polygenic risk scores (PRS) summarize these effects. A PRS based on a GWAS for plasma docosahexaenoic fatty acid (DHA) has been created, based on SNPs from 9 genes.
Objective: To analyze the interaction between the PRS for plasma DHA concentration, body composition and eating behaviour (using the Children Eating Behaviour Questionnaire) in childhood. Subjects/Methods: We analyzed a subsample of children from the Maternal, Adversity, Vulnerability and Neurodevelopment (MAVAN) cohort with PRS and measurements of eating behaviour performed at 4 years of age (n = 210), 6 y (n = 177), and body fat determined by bioelectric impedance at 4 y and 6 y or by air displacement plethysmography and dual-energy X-ray absorptiometry at 8 y (n = 42 and n = 37). PRS was based on the GWAS from Lemaitre et al. 2011 (p threshold = p < 5*10-6), and a median split created low and high PRS groups (high PRS = higher DHA level). Results: In ALSPAC children, we observed an association between PRS and plasma DHA concentration (β = 0.100, p < 0.01) and proportion (β = 0.107, p < 0.01). In MAVAN, there were interactions between PRS and body fat on pro-intake scores in childhood, in which low PRS and higher body fat were linked to altered behaviour. There were also interactions between PRS and pro-intake scores early in childhood on body fat later in childhood, suggesting that the genetic profile and eating behaviour influence the development of adiposity at later ages.
Conclusions: A lower PRS (lower plasma PUFA) can be a risk factor for developing higher body fat associated with non-adaptive eating behaviour in childhood; it is possible that the higher PRS (higher plasma PUFA) is a protective feature."},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Jaramillo A, Casanello P, Andersen R, Levitan R, Meaney M, Silveira PP.
- Cómo citar: Jaramillo A, Casanello P, Andersen R, Levitan R, Meaney M, Silveira PP. Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behavior, and body composition in children. Int. J. Obes. 2022; 46:977–985. doi: 10.1038/s41366-022-01067-6. PMID: 35058573. ISSN: 0307-0565. IF [JCR]: 5.551. Q2
- Resumen: "Background: The relationship between eating behaviour and current body weight has been described. However little is known about the effect of polyunsaturated fatty acids (PUFA) in this relationship. Genetic contribution to a certain condition is derived from a combination of small effects from many genetic variants, and polygenic risk scores (PRS) summarize these effects. A PRS based on a GWAS for plasma docosahexaenoic fatty acid (DHA) has been created, based on SNPs from 9 genes.
Objective: To analyze the interaction between the PRS for plasma DHA concentration, body composition and eating behaviour (using the Children Eating Behaviour Questionnaire) in childhood. Subjects/Methods: We analyzed a subsample of children from the Maternal, Adversity, Vulnerability and Neurodevelopment (MAVAN) cohort with PRS and measurements of eating behaviour performed at 4 years of age (n = 210), 6 y (n = 177), and body fat determined by bioelectric impedance at 4 y and 6 y or by air displacement plethysmography and dual-energy X-ray absorptiometry at 8 y (n = 42 and n = 37). PRS was based on the GWAS from Lemaitre et al. 2011 (p threshold = p < 5*10-6), and a median split created low and high PRS groups (high PRS = higher DHA level). Results: In ALSPAC children, we observed an association between PRS and plasma DHA concentration (β = 0.100, p < 0.01) and proportion (β = 0.107, p < 0.01). In MAVAN, there were interactions between PRS and body fat on pro-intake scores in childhood, in which low PRS and higher body fat were linked to altered behaviour. There were also interactions between PRS and pro-intake scores early in childhood on body fat later in childhood, suggesting that the genetic profile and eating behaviour influence the development of adiposity at later ages.
Conclusions: A lower PRS (lower plasma PUFA) can be a risk factor for developing higher body fat associated with non-adaptive eating behaviour in childhood; it is possible that the higher PRS (higher plasma PUFA) is a protective feature."
- Cómo citar: Jaramillo A, Casanello P, Andersen R, Levitan R, Meaney M, Silveira PP. Interactions between a polygenic risk score for plasma docosahexaenoic fatty acid concentration, eating behavior, and body composition in children. Int. J. Obes. 2022; 46:977–985. doi: 10.1038/s41366-022-01067-6. PMID: 35058573. ISSN: 0307-0565. IF [JCR]: 5.551. Q2
- Resumen: "Background: The relationship between eating behaviour and current body weight has been described. However little is known about the effect of polyunsaturated fatty acids (PUFA) in this relationship. Genetic contribution to a certain condition is derived from a combination of small effects from many genetic variants, and polygenic risk scores (PRS) summarize these effects. A PRS based on a GWAS for plasma docosahexaenoic fatty acid (DHA) has been created, based on SNPs from 9 genes.
Objective: To analyze the interaction between the PRS for plasma DHA concentration, body composition and eating behaviour (using the Children Eating Behaviour Questionnaire) in childhood. Subjects/Methods: We analyzed a subsample of children from the Maternal, Adversity, Vulnerability and Neurodevelopment (MAVAN) cohort with PRS and measurements of eating behaviour performed at 4 years of age (n = 210), 6 y (n = 177), and body fat determined by bioelectric impedance at 4 y and 6 y or by air displacement plethysmography and dual-energy X-ray absorptiometry at 8 y (n = 42 and n = 37). PRS was based on the GWAS from Lemaitre et al. 2011 (p threshold = p < 5*10-6), and a median split created low and high PRS groups (high PRS = higher DHA level). Results: In ALSPAC children, we observed an association between PRS and plasma DHA concentration (β = 0.100, p < 0.01) and proportion (β = 0.107, p < 0.01). In MAVAN, there were interactions between PRS and body fat on pro-intake scores in childhood, in which low PRS and higher body fat were linked to altered behaviour. There were also interactions between PRS and pro-intake scores early in childhood on body fat later in childhood, suggesting that the genetic profile and eating behaviour influence the development of adiposity at later ages.
Conclusions: A lower PRS (lower plasma PUFA) can be a risk factor for developing higher body fat associated with non-adaptive eating behaviour in childhood; it is possible that the higher PRS (higher plasma PUFA) is a protective feature."
Mujica, Fernanda
En: J. Nutr., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {Micronutrient, metabolic and inflammatory biomarkers through 24 months of age in infants receiving formula with added bovine milk fat globule membrane through the first year of life: a randomized controlled trial},
author = {Fernanda Mujica},
doi = {doi: 10.1016/j.tjnut.2022.12.006},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {J. Nutr.},
abstract = {- Otros autores: Jaramillo-Ospina AM, Murguia-Peniche T, Wampler JL, Wu S, Berseth CL, Weisstaub G, Uauy R.
- Cómo citar: Jaramillo-Ospina AM, Mujica-Coopman MF, Murguia-Peniche T, Wampler JL, Wu S, Berseth CL, Weisstaub G, Uauy R. Micronutrient, metabolic and inflammatory biomarkers through 24 months of age in infants receiving formula with added bovine milk fat globule membrane through the first year of life: a randomized controlled trial. J. Nutr. 2022;Preprint. doi: 10.1016/j.tjnut.2022.12.006. ISSN: 0022-3166. IF [JCR]: 4.735. Q1
},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Jaramillo-Ospina AM, Murguia-Peniche T, Wampler JL, Wu S, Berseth CL, Weisstaub G, Uauy R.
- Cómo citar: Jaramillo-Ospina AM, Mujica-Coopman MF, Murguia-Peniche T, Wampler JL, Wu S, Berseth CL, Weisstaub G, Uauy R. Micronutrient, metabolic and inflammatory biomarkers through 24 months of age in infants receiving formula with added bovine milk fat globule membrane through the first year of life: a randomized controlled trial. J. Nutr. 2022;Preprint. doi: 10.1016/j.tjnut.2022.12.006. ISSN: 0022-3166. IF [JCR]: 4.735. Q1
- Cómo citar: Jaramillo-Ospina AM, Mujica-Coopman MF, Murguia-Peniche T, Wampler JL, Wu S, Berseth CL, Weisstaub G, Uauy R. Micronutrient, metabolic and inflammatory biomarkers through 24 months of age in infants receiving formula with added bovine milk fat globule membrane through the first year of life: a randomized controlled trial. J. Nutr. 2022;Preprint. doi: 10.1016/j.tjnut.2022.12.006. ISSN: 0022-3166. IF [JCR]: 4.735. Q1
Corvalán, Camila; Garmendia, María Luisa
Respuesta a la carta: Impacto del cambio de punto de corte en el estándar de Atalah en la clasificación del estado nutricional de bajo peso durante el embarazo. Artículo de revista
En: Rev. Chil. Nutr., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_63,
title = {Respuesta a la carta: Impacto del cambio de punto de corte en el estándar de Atalah en la clasificación del estado nutricional de bajo peso durante el embarazo.},
author = {Camila Corvalán and María Luisa Garmendia},
doi = {10.4067/S0717-75182022000200289},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Rev. Chil. Nutr.},
abstract = {- Otros autores: Araya M, Kusanovic JP.
- Cómo citar: Araya M, Kusanovic JP. Respuesta a la carta: Impacto del cambio de punto de corte en el estándar de Atalah en la clasificación del estado nutricional de bajo peso durante el embarazo. Rev. Chil. Nutr. 2022;49(2): 289-290. doi: 10.4067/S0717-75182022000200289. N/A ISSN: 0717-7518. IF [JCI]: 0.12. Q4},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Araya M, Kusanovic JP.
- Cómo citar: Araya M, Kusanovic JP. Respuesta a la carta: Impacto del cambio de punto de corte en el estándar de Atalah en la clasificación del estado nutricional de bajo peso durante el embarazo. Rev. Chil. Nutr. 2022;49(2): 289-290. doi: 10.4067/S0717-75182022000200289. N/A ISSN: 0717-7518. IF [JCI]: 0.12. Q4
- Cómo citar: Araya M, Kusanovic JP. Respuesta a la carta: Impacto del cambio de punto de corte en el estándar de Atalah en la clasificación del estado nutricional de bajo peso durante el embarazo. Rev. Chil. Nutr. 2022;49(2): 289-290. doi: 10.4067/S0717-75182022000200289. N/A ISSN: 0717-7518. IF [JCI]: 0.12. Q4
Garmendia, María Luisa
Socio-economic inequalities in the effect of public policies and the COVID-19 pandemic on exclusive breastfeeding in Chile Artículo de revista
En: Public Health., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {Socio-economic inequalities in the effect of public policies and the COVID-19 pandemic on exclusive breastfeeding in Chile},
author = {María Luisa Garmendia},
doi = {10.1016/j.puhe.2022.11.001},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Public Health.},
abstract = {- Otros autores: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez-Arana S, Rodriguez-Osiac L.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez-Arana S, Rodriguez-Osiac L, Garmendia ML. Socio-economic inequalities in the effect of public policies and the COVID-19 pandemic on exclusive breastfeeding in Chile. Public Health. 2022;214:61-68. doi: 10.1016/j.puhe.2022.11.001. N/A. ISSN: 0033-3506. IF [JCR]: 4.984. Q2
- Resumen: Objective: To assess the impact of the addition of 12 maternity leave (ML) weeks (2011), a pay for performance (P4P) exclusive breastfeeding (EBF) promotion strategy (2015), and the COVID-19 pandemic in EBF inequalities in Chile.
Study design: Interrupted time-series analyses (ITSAs).
Methods: Aggregated national EBF data by municipality and month were collected from 2009 to 2020. We assess the impact of the three events in EBF inequalities using two procedures: 1. ITSA stratified by municipal SES quintiles (Q1-Q5); 2. Calculating the EBF slope index of inequality (SII).
Results: The EBF prevalence was higher in lower SES municipalities before and after the three time-events. No impact in EBF inequalities was observed after the extended ML. The P4P strategy increased EBF at six months in all SES quintiles (effect size between 4% and 5%), but in a higher level in poorer municipalities (SII: -0.36% and -1.05%). During COVID-19, wealthier municipalities showed a slightly higher EBF at six months prevalence (SII: 1.44%).
Conclusion: The null impact of the extended ML in EBF inequalities could be explained by a low access to ML among affiliated to the public health system (20%). The P4P strategy includes multiple interventions that seemed effective in increasing EBF across all SES quintiles, but further in lower quintiles. The restrictions in healthcare access in poorer municipalities could explain EBF inequalities during COVID-19.
Keywords: COVID-19; Chile; Exclusive breastfeeding; Health policy; Interrupted time-series; Maternity leave; Socio-economic inequalities.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez-Arana S, Rodriguez-Osiac L.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez-Arana S, Rodriguez-Osiac L, Garmendia ML. Socio-economic inequalities in the effect of public policies and the COVID-19 pandemic on exclusive breastfeeding in Chile. Public Health. 2022;214:61-68. doi: 10.1016/j.puhe.2022.11.001. N/A. ISSN: 0033-3506. IF [JCR]: 4.984. Q2
- Resumen: Objective: To assess the impact of the addition of 12 maternity leave (ML) weeks (2011), a pay for performance (P4P) exclusive breastfeeding (EBF) promotion strategy (2015), and the COVID-19 pandemic in EBF inequalities in Chile.
Study design: Interrupted time-series analyses (ITSAs).
Methods: Aggregated national EBF data by municipality and month were collected from 2009 to 2020. We assess the impact of the three events in EBF inequalities using two procedures: 1. ITSA stratified by municipal SES quintiles (Q1-Q5); 2. Calculating the EBF slope index of inequality (SII).
Results: The EBF prevalence was higher in lower SES municipalities before and after the three time-events. No impact in EBF inequalities was observed after the extended ML. The P4P strategy increased EBF at six months in all SES quintiles (effect size between 4% and 5%), but in a higher level in poorer municipalities (SII: -0.36% and -1.05%). During COVID-19, wealthier municipalities showed a slightly higher EBF at six months prevalence (SII: 1.44%).
Conclusion: The null impact of the extended ML in EBF inequalities could be explained by a low access to ML among affiliated to the public health system (20%). The P4P strategy includes multiple interventions that seemed effective in increasing EBF across all SES quintiles, but further in lower quintiles. The restrictions in healthcare access in poorer municipalities could explain EBF inequalities during COVID-19.
Keywords: COVID-19; Chile; Exclusive breastfeeding; Health policy; Interrupted time-series; Maternity leave; Socio-economic inequalities.
- Cómo citar: Navarro-Rosenblatt D, Benmarhnia T, Bedregal P, Lopez-Arana S, Rodriguez-Osiac L, Garmendia ML. Socio-economic inequalities in the effect of public policies and the COVID-19 pandemic on exclusive breastfeeding in Chile. Public Health. 2022;214:61-68. doi: 10.1016/j.puhe.2022.11.001. N/A. ISSN: 0033-3506. IF [JCR]: 4.984. Q2
- Resumen: Objective: To assess the impact of the addition of 12 maternity leave (ML) weeks (2011), a pay for performance (P4P) exclusive breastfeeding (EBF) promotion strategy (2015), and the COVID-19 pandemic in EBF inequalities in Chile.
Study design: Interrupted time-series analyses (ITSAs).
Methods: Aggregated national EBF data by municipality and month were collected from 2009 to 2020. We assess the impact of the three events in EBF inequalities using two procedures: 1. ITSA stratified by municipal SES quintiles (Q1-Q5); 2. Calculating the EBF slope index of inequality (SII).
Results: The EBF prevalence was higher in lower SES municipalities before and after the three time-events. No impact in EBF inequalities was observed after the extended ML. The P4P strategy increased EBF at six months in all SES quintiles (effect size between 4% and 5%), but in a higher level in poorer municipalities (SII: -0.36% and -1.05%). During COVID-19, wealthier municipalities showed a slightly higher EBF at six months prevalence (SII: 1.44%).
Conclusion: The null impact of the extended ML in EBF inequalities could be explained by a low access to ML among affiliated to the public health system (20%). The P4P strategy includes multiple interventions that seemed effective in increasing EBF across all SES quintiles, but further in lower quintiles. The restrictions in healthcare access in poorer municipalities could explain EBF inequalities during COVID-19.
Keywords: COVID-19; Chile; Exclusive breastfeeding; Health policy; Interrupted time-series; Maternity leave; Socio-economic inequalities.
Corvalán, Camila; Garmendia, María Luisa; Mujica, Fernanda
The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: A study protocol. Artículo de revista
En: Front. Public Health., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_62,
title = {The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: A study protocol.},
author = {Camila Corvalán and María Luisa Garmendia and Fernanda Mujica},
doi = {10.3389/fpubh.2022.904668},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Front. Public Health.},
abstract = {- Otros autores: Mujica-Coopman MF, Flores M.
- Cómo citar: Mujica-Coopman MF, Flores M. The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: A study protocol. Front. Public Health. 2022;10:904668. doi: 10.3389/fpubh.2022.904668. ISSN: 2296-2565. IF [JCI]: 6.461. Q1
- Resumen: "Background: Pregnancy is a critical developmental window in which optimal maternal nutrition and health are key for pregnancy and infant development. The COVID-19 pandemic is considered as a “natural experiment” in which maternal and infant nutrition and health challenges were faced especially in developing countries. Therefore, understanding the health consequences for mothers and infants living in the COVID-19 era is key to revisit public health measures focused on maternal and infant health. The current work aims to describe the design, methods, and descriptive information at recruitment and preliminary findings of the Chilean Maternal & Infant Cohort Study II (CHiMINCs-II) cohort.
Methods: The CHiMINCs-II is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1954 pregnant women beneficiaries of the public health systems and their offspring were recruited before 15 weeks of gestation and are followed across pregnancy (<15, 26–28, and 35–37 weeks of gestation) and up to 2 years of age in their offspring. Two studies are currently nested within the CHiMINCs-II cohort: (1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and (2) the CHiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, insulin growth factor 1, and hemoglobin A1c concentrations) at early pregnancy (i.e., <15 and 26–28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the CHiMINCs-COVID study is to assess maternal dietary intake and mental health problems derived from the COVID-19 pandemic and their association with maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health, and COVID-related information at each trimester, along with neonatal and infant nutritional information.
Discussion: The findings of this study will provide novel and critical information to better understand maternal nutritional status, mental health, as well as infant growth and nutrition during the COVID-19 era.
Clinical Trial Registration: BRECAM study registration number NCT03920098 and CHiMINCs-COVID study registration number NCT01916603."},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Mujica-Coopman MF, Flores M.
- Cómo citar: Mujica-Coopman MF, Flores M. The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: A study protocol. Front. Public Health. 2022;10:904668. doi: 10.3389/fpubh.2022.904668. ISSN: 2296-2565. IF [JCI]: 6.461. Q1
- Resumen: "Background: Pregnancy is a critical developmental window in which optimal maternal nutrition and health are key for pregnancy and infant development. The COVID-19 pandemic is considered as a “natural experiment” in which maternal and infant nutrition and health challenges were faced especially in developing countries. Therefore, understanding the health consequences for mothers and infants living in the COVID-19 era is key to revisit public health measures focused on maternal and infant health. The current work aims to describe the design, methods, and descriptive information at recruitment and preliminary findings of the Chilean Maternal & Infant Cohort Study II (CHiMINCs-II) cohort.
Methods: The CHiMINCs-II is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1954 pregnant women beneficiaries of the public health systems and their offspring were recruited before 15 weeks of gestation and are followed across pregnancy (<15, 26–28, and 35–37 weeks of gestation) and up to 2 years of age in their offspring. Two studies are currently nested within the CHiMINCs-II cohort: (1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and (2) the CHiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, insulin growth factor 1, and hemoglobin A1c concentrations) at early pregnancy (i.e., <15 and 26–28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the CHiMINCs-COVID study is to assess maternal dietary intake and mental health problems derived from the COVID-19 pandemic and their association with maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health, and COVID-related information at each trimester, along with neonatal and infant nutritional information.
Discussion: The findings of this study will provide novel and critical information to better understand maternal nutritional status, mental health, as well as infant growth and nutrition during the COVID-19 era.
Clinical Trial Registration: BRECAM study registration number NCT03920098 and CHiMINCs-COVID study registration number NCT01916603."
- Cómo citar: Mujica-Coopman MF, Flores M. The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: A study protocol. Front. Public Health. 2022;10:904668. doi: 10.3389/fpubh.2022.904668. ISSN: 2296-2565. IF [JCI]: 6.461. Q1
- Resumen: "Background: Pregnancy is a critical developmental window in which optimal maternal nutrition and health are key for pregnancy and infant development. The COVID-19 pandemic is considered as a “natural experiment” in which maternal and infant nutrition and health challenges were faced especially in developing countries. Therefore, understanding the health consequences for mothers and infants living in the COVID-19 era is key to revisit public health measures focused on maternal and infant health. The current work aims to describe the design, methods, and descriptive information at recruitment and preliminary findings of the Chilean Maternal & Infant Cohort Study II (CHiMINCs-II) cohort.
Methods: The CHiMINCs-II is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1954 pregnant women beneficiaries of the public health systems and their offspring were recruited before 15 weeks of gestation and are followed across pregnancy (<15, 26–28, and 35–37 weeks of gestation) and up to 2 years of age in their offspring. Two studies are currently nested within the CHiMINCs-II cohort: (1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and (2) the CHiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, insulin growth factor 1, and hemoglobin A1c concentrations) at early pregnancy (i.e., <15 and 26–28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the CHiMINCs-COVID study is to assess maternal dietary intake and mental health problems derived from the COVID-19 pandemic and their association with maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health, and COVID-related information at each trimester, along with neonatal and infant nutritional information.
Discussion: The findings of this study will provide novel and critical information to better understand maternal nutritional status, mental health, as well as infant growth and nutrition during the COVID-19 era.
Clinical Trial Registration: BRECAM study registration number NCT03920098 and CHiMINCs-COVID study registration number NCT01916603."
Cordero, Miguel
The importance of birth cohort studies to low and middle income countries. Artículo de revista
En: Psychol. Health Med., 2022.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_60,
title = {The importance of birth cohort studies to low and middle income countries.},
author = {Miguel Cordero},
doi = {10.1080/13548506.2022.2067345},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Psychol. Health Med.},
abstract = {- Otros autores: Cordero M, Golding J.
- Cómo citar: Cordero M, Golding J. The importance of birth cohort studies to low and middle income countries. Psychol. Health Med. 2022;Online ahead of print. doi: 10.1080/13548506.2022.2067345. PMID: 35450489. ISSN: 1354-8506. IF [JCR]: 3.898. Q2
- Resumen: In order to discern the causes of the health and developmental problems of children, and thence develop preventative strategies, longitudinal cohort studies offer major advantages. They can monitor the consequences of exposure to physical and psychological events and thence identify antecedents of various disorders. We describe the historical background to the development in the UK of this study design, and the uptake of longitudinal birth cohorts in low- and middle-income countries (LMICs), using the cohorts in Jamaica, South Africa and Brazil as exemplars. We describe the benefits of such studies and show how undertaking longitudinal cohort studies can have major health and financial benefits to the populations concerned. Additionally, the paper outlines the advantages of collaboration between studies and the pooling of data.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Cordero M, Golding J.
- Cómo citar: Cordero M, Golding J. The importance of birth cohort studies to low and middle income countries. Psychol. Health Med. 2022;Online ahead of print. doi: 10.1080/13548506.2022.2067345. PMID: 35450489. ISSN: 1354-8506. IF [JCR]: 3.898. Q2
- Resumen: In order to discern the causes of the health and developmental problems of children, and thence develop preventative strategies, longitudinal cohort studies offer major advantages. They can monitor the consequences of exposure to physical and psychological events and thence identify antecedents of various disorders. We describe the historical background to the development in the UK of this study design, and the uptake of longitudinal birth cohorts in low- and middle-income countries (LMICs), using the cohorts in Jamaica, South Africa and Brazil as exemplars. We describe the benefits of such studies and show how undertaking longitudinal cohort studies can have major health and financial benefits to the populations concerned. Additionally, the paper outlines the advantages of collaboration between studies and the pooling of data.
- Cómo citar: Cordero M, Golding J. The importance of birth cohort studies to low and middle income countries. Psychol. Health Med. 2022;Online ahead of print. doi: 10.1080/13548506.2022.2067345. PMID: 35450489. ISSN: 1354-8506. IF [JCR]: 3.898. Q2
- Resumen: In order to discern the causes of the health and developmental problems of children, and thence develop preventative strategies, longitudinal cohort studies offer major advantages. They can monitor the consequences of exposure to physical and psychological events and thence identify antecedents of various disorders. We describe the historical background to the development in the UK of this study design, and the uptake of longitudinal birth cohorts in low- and middle-income countries (LMICs), using the cohorts in Jamaica, South Africa and Brazil as exemplars. We describe the benefits of such studies and show how undertaking longitudinal cohort studies can have major health and financial benefits to the populations concerned. Additionally, the paper outlines the advantages of collaboration between studies and the pooling of data.
2021
Toro, Rosario
Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT Artículo de revista
En: Curr Dev Nutr., 2021.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_83,
title = {Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT},
author = {Rosario Toro},
doi = {10.1093/cdn/nzaa054_086},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Curr Dev Nutr.},
abstract = {- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R.
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT Curr Dev Nutr. 2021;4(Suppl 2):1014. doi: 10.1093/cdn/nzaa054_086. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: Objectives: To evaluate growth through 24 months of age in infants receiving added bovine milk fat globule membrane (MFGM) in infant formula through 12 months of age. Concentration of MFGM from bovine milk fractions and incorporation in infant formula may better approximate the composition of complex milk lipids in human milk. Methods: In the double-blind, randomized, controlled Chilean Infant Nutrition Trial (ChiNuT; NCT0262613), term infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age were randomized to receive: a standard cow's milk-based infant formula (SF},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R.
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT Curr Dev Nutr. 2021;4(Suppl 2):1014. doi: 10.1093/cdn/nzaa054_086. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: Objectives: To evaluate growth through 24 months of age in infants receiving added bovine milk fat globule membrane (MFGM) in infant formula through 12 months of age. Concentration of MFGM from bovine milk fractions and incorporation in infant formula may better approximate the composition of complex milk lipids in human milk. Methods: In the double-blind, randomized, controlled Chilean Infant Nutrition Trial (ChiNuT; NCT0262613), term infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age were randomized to receive: a standard cow's milk-based infant formula (SF
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Growth Through 24 Months of Age in Infants Receiving Formulas with or Without Added Bovine Milk Fat Globule Membrane (MFGM) or Human Milk Through the First Year of Life: An RCT Curr Dev Nutr. 2021;4(Suppl 2):1014. doi: 10.1093/cdn/nzaa054_086. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: Objectives: To evaluate growth through 24 months of age in infants receiving added bovine milk fat globule membrane (MFGM) in infant formula through 12 months of age. Concentration of MFGM from bovine milk fractions and incorporation in infant formula may better approximate the composition of complex milk lipids in human milk. Methods: In the double-blind, randomized, controlled Chilean Infant Nutrition Trial (ChiNuT; NCT0262613), term infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age were randomized to receive: a standard cow's milk-based infant formula (SF
Corvalán, Camila; Garmendia, María Luisa
Impact of the change of the Atalah standard cut-off point to classify underweight nutritional status during pregnancy. Artículo de revista
En: Rev. Chil. Nutr., 2021.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokeye,
title = {Impact of the change of the Atalah standard cut-off point to classify underweight nutritional status during pregnancy.},
author = {Camila Corvalán and María Luisa Garmendia},
doi = {10.4067/S0717-75182021000500717},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Rev. Chil. Nutr.},
abstract = {- Otros autores: Araya M, Kusanovic JP.
- Cómo citar: Araya M, Kusanovic JP. Impact of the change of the Atalah standard cut-off point to classify underweight nutritional status during pregnancy. Rev. Chil. Nutr. 2021;48(5):717-725. doi: 10.4067/S0717-75182021000500717. N/A ISSN: 0716-1549. IF [JCI]: 0.12. Q4 - Resumen: Methods: Data from clinical records of single birth pregnancies (n= 59,476) at the Sótero del Río Hospital, between 2003-2012 were collected. We compared 1. nutritional status, 2. proportion of excessive gestational weight gain, 3. association between nutritional status and neonatal outcomes (large/small for gestational age, low birth weight, preterm birth and macrosomia), using logistic regression models, and 4. Sensitivity, specificity, and predictive values to predict adverse neonatal outcomes per nutritional status. Results: Pre-pregnancy underweight decreased from 8.6% to 2.5% and women with BMI between 18.5-19.9kg/m², who exceeded the recommended gestational weight gain increased from 32.7% to 49.2% when using IOM2009 instead of Atalah. Both standards showed low sensitivity, but the IOM2009 cut-off points showed better specificity for identifying healthy newborns. Conclusion: The cut-off points recommended by the IOM2009 better identify the prevalence of underweight and normal weight during pregnancy without increasing neonatal risk. This study supports the recent change of the Ministry of Health in adopting the WHO cut-off points during pregnancy.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Araya M, Kusanovic JP.
- Cómo citar: Araya M, Kusanovic JP. Impact of the change of the Atalah standard cut-off point to classify underweight nutritional status during pregnancy. Rev. Chil. Nutr. 2021;48(5):717-725. doi: 10.4067/S0717-75182021000500717. N/A ISSN: 0716-1549. IF [JCI]: 0.12. Q4 - Resumen: Methods: Data from clinical records of single birth pregnancies (n= 59,476) at the Sótero del Río Hospital, between 2003-2012 were collected. We compared 1. nutritional status, 2. proportion of excessive gestational weight gain, 3. association between nutritional status and neonatal outcomes (large/small for gestational age, low birth weight, preterm birth and macrosomia), using logistic regression models, and 4. Sensitivity, specificity, and predictive values to predict adverse neonatal outcomes per nutritional status. Results: Pre-pregnancy underweight decreased from 8.6% to 2.5% and women with BMI between 18.5-19.9kg/m², who exceeded the recommended gestational weight gain increased from 32.7% to 49.2% when using IOM2009 instead of Atalah. Both standards showed low sensitivity, but the IOM2009 cut-off points showed better specificity for identifying healthy newborns. Conclusion: The cut-off points recommended by the IOM2009 better identify the prevalence of underweight and normal weight during pregnancy without increasing neonatal risk. This study supports the recent change of the Ministry of Health in adopting the WHO cut-off points during pregnancy.
- Cómo citar: Araya M, Kusanovic JP. Impact of the change of the Atalah standard cut-off point to classify underweight nutritional status during pregnancy. Rev. Chil. Nutr. 2021;48(5):717-725. doi: 10.4067/S0717-75182021000500717. N/A ISSN: 0716-1549. IF [JCI]: 0.12. Q4 - Resumen: Methods: Data from clinical records of single birth pregnancies (n= 59,476) at the Sótero del Río Hospital, between 2003-2012 were collected. We compared 1. nutritional status, 2. proportion of excessive gestational weight gain, 3. association between nutritional status and neonatal outcomes (large/small for gestational age, low birth weight, preterm birth and macrosomia), using logistic regression models, and 4. Sensitivity, specificity, and predictive values to predict adverse neonatal outcomes per nutritional status. Results: Pre-pregnancy underweight decreased from 8.6% to 2.5% and women with BMI between 18.5-19.9kg/m², who exceeded the recommended gestational weight gain increased from 32.7% to 49.2% when using IOM2009 instead of Atalah. Both standards showed low sensitivity, but the IOM2009 cut-off points showed better specificity for identifying healthy newborns. Conclusion: The cut-off points recommended by the IOM2009 better identify the prevalence of underweight and normal weight during pregnancy without increasing neonatal risk. This study supports the recent change of the Ministry of Health in adopting the WHO cut-off points during pregnancy.
Toro, Rosario
Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants Receiving Formula With Added Bovine Milk Fat Globule Membrane Through the First Year of Life: An RCT Artículo de revista
En: Curr Dev Nutr., 2021.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_82,
title = {Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants Receiving Formula With Added Bovine Milk Fat Globule Membrane Through the First Year of Life: An RCT},
author = {Rosario Toro},
doi = {10.1093/cdn/nzab046_059},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Curr Dev Nutr.},
abstract = {- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R.
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants
Receiving Formula With Added Bovine Milk Fat Globule Membrane Through
the First Year of Life: An RCT Curr Dev Nutr. 2021;5(Suppl 2):762. doi: 10.1093/cdn/nzab046_059. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: "Objectives: Bovine milk fat globule membrane (bMFGM) added in routine infant formula supports normal growth and safety through 24 mo of age in term infants. The impact on micronutrients and glucose-related biomarkers is assessed here. Methods: In this double-blind, randomized, controlled trial, formula-fed infants were enrolled (<120 days of age) and randomized to receive a standard cow´s milk-based infant formula (SF},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Jaramillo AM, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R.
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants
Receiving Formula With Added Bovine Milk Fat Globule Membrane Through
the First Year of Life: An RCT Curr Dev Nutr. 2021;5(Suppl 2):762. doi: 10.1093/cdn/nzab046_059. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: "Objectives: Bovine milk fat globule membrane (bMFGM) added in routine infant formula supports normal growth and safety through 24 mo of age in term infants. The impact on micronutrients and glucose-related biomarkers is assessed here. Methods: In this double-blind, randomized, controlled trial, formula-fed infants were enrolled (<120 days of age) and randomized to receive a standard cow´s milk-based infant formula (SF
- Cómo citar: Jaramillo AM, Toro R, Murguia-Peniche T, Wampler J, Wu S, Berseth CL, Uauy R. Micronutrient and Glucose-Related Biomarkers Until 24 Mo of Age in Infants
Receiving Formula With Added Bovine Milk Fat Globule Membrane Through
the First Year of Life: An RCT Curr Dev Nutr. 2021;5(Suppl 2):762. doi: 10.1093/cdn/nzab046_059. PMC: 7258361. ISSN: 2475-2991. IF [JCI]: 0.59. Q3
-Resumen: "Objectives: Bovine milk fat globule membrane (bMFGM) added in routine infant formula supports normal growth and safety through 24 mo of age in term infants. The impact on micronutrients and glucose-related biomarkers is assessed here. Methods: In this double-blind, randomized, controlled trial, formula-fed infants were enrolled (<120 days of age) and randomized to receive a standard cow´s milk-based infant formula (SF
Garmendia, María Luisa
Tendencia y causas de la mortalidad materna en Chile de 1990 a 2018 [Trends and causes of maternal deaths from 1990 to 2018]. Artículo de revista
En: Rev. Med. Chile., 2021.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokeyd,
title = {Tendencia y causas de la mortalidad materna en Chile de 1990 a 2018 [Trends and causes of maternal deaths from 1990 to 2018].},
author = {María Luisa Garmendia},
doi = {10.4067/s0034-98872021001001440},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Rev. Med. Chile.},
abstract = {- Otros autores: Flores M.
- Cómo citar: Flores M. Tendencia y causas de la mortalidad materna en Chile de 1990 a 2018 [Trends and causes of maternal deaths from 1990 to 2018]. Rev. Med. Chile. 2021;149(10): 1440-1449. doi: 10.4067/s0034-98872021001001440. PMID: 35319633. ISSN: 0034-9887. IF [JCR] 0.553. Q4
- Resumen: Background: Previous studies have shown a decrease in the maternal mortality (MM) rates in Chile, with a trend towards stability since 2001. However, some of its associated causes such as high blood pressure, obesity, or maternal age, have increased in the last years.
Aim: To describe the trend and characteristics of MM in Chile between 1990 and 2018.
Material and Methods: MM rates were calculated using death records available at the website of the Department of Health Statistics of the Ministry of Health, using the codes 630 to 679 of the International Classification Diseases (ICD)-9 (630-679) and O00-O99 from ICD-10. Live births were obtained from vital statistics of the National Statistics Institute (INE). The age at the time of death and the causes were recorded. Polynomial and Prais-Winsten modelings were applied.
Results: There were 1,728 maternal deaths with an overall rate for the period of 23 / 100,000 live births. An inflection of the trend was observed in 2003, with a decrease between 1990-2003 and an increase between 2004-2018. While in the 1990-2003 period all age groups decreased their rate, in 2004-2018 it increased significantly in the 20-34 age group. Concerning the causes, “other obstetric conditions not classified elsewhere” showed a steady upward trend, particularly the late maternal deaths or deaths from sequelae of obstetric causes (O96-O97).
Conclusions: MM rates increased in Chile in recent years, mainly due to the increase in women aged 20 to 34 years and in causes referred to as “other obstetric conditions not classified elsewhere.” It is possible that changes in risk factors and in the registries could explain this increase.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Flores M.
- Cómo citar: Flores M. Tendencia y causas de la mortalidad materna en Chile de 1990 a 2018 [Trends and causes of maternal deaths from 1990 to 2018]. Rev. Med. Chile. 2021;149(10): 1440-1449. doi: 10.4067/s0034-98872021001001440. PMID: 35319633. ISSN: 0034-9887. IF [JCR] 0.553. Q4
- Resumen: Background: Previous studies have shown a decrease in the maternal mortality (MM) rates in Chile, with a trend towards stability since 2001. However, some of its associated causes such as high blood pressure, obesity, or maternal age, have increased in the last years.
Aim: To describe the trend and characteristics of MM in Chile between 1990 and 2018.
Material and Methods: MM rates were calculated using death records available at the website of the Department of Health Statistics of the Ministry of Health, using the codes 630 to 679 of the International Classification Diseases (ICD)-9 (630-679) and O00-O99 from ICD-10. Live births were obtained from vital statistics of the National Statistics Institute (INE). The age at the time of death and the causes were recorded. Polynomial and Prais-Winsten modelings were applied.
Results: There were 1,728 maternal deaths with an overall rate for the period of 23 / 100,000 live births. An inflection of the trend was observed in 2003, with a decrease between 1990-2003 and an increase between 2004-2018. While in the 1990-2003 period all age groups decreased their rate, in 2004-2018 it increased significantly in the 20-34 age group. Concerning the causes, “other obstetric conditions not classified elsewhere” showed a steady upward trend, particularly the late maternal deaths or deaths from sequelae of obstetric causes (O96-O97).
Conclusions: MM rates increased in Chile in recent years, mainly due to the increase in women aged 20 to 34 years and in causes referred to as “other obstetric conditions not classified elsewhere.” It is possible that changes in risk factors and in the registries could explain this increase.
- Cómo citar: Flores M. Tendencia y causas de la mortalidad materna en Chile de 1990 a 2018 [Trends and causes of maternal deaths from 1990 to 2018]. Rev. Med. Chile. 2021;149(10): 1440-1449. doi: 10.4067/s0034-98872021001001440. PMID: 35319633. ISSN: 0034-9887. IF [JCR] 0.553. Q4
- Resumen: Background: Previous studies have shown a decrease in the maternal mortality (MM) rates in Chile, with a trend towards stability since 2001. However, some of its associated causes such as high blood pressure, obesity, or maternal age, have increased in the last years.
Aim: To describe the trend and characteristics of MM in Chile between 1990 and 2018.
Material and Methods: MM rates were calculated using death records available at the website of the Department of Health Statistics of the Ministry of Health, using the codes 630 to 679 of the International Classification Diseases (ICD)-9 (630-679) and O00-O99 from ICD-10. Live births were obtained from vital statistics of the National Statistics Institute (INE). The age at the time of death and the causes were recorded. Polynomial and Prais-Winsten modelings were applied.
Results: There were 1,728 maternal deaths with an overall rate for the period of 23 / 100,000 live births. An inflection of the trend was observed in 2003, with a decrease between 1990-2003 and an increase between 2004-2018. While in the 1990-2003 period all age groups decreased their rate, in 2004-2018 it increased significantly in the 20-34 age group. Concerning the causes, “other obstetric conditions not classified elsewhere” showed a steady upward trend, particularly the late maternal deaths or deaths from sequelae of obstetric causes (O96-O97).
Conclusions: MM rates increased in Chile in recent years, mainly due to the increase in women aged 20 to 34 years and in causes referred to as “other obstetric conditions not classified elsewhere.” It is possible that changes in risk factors and in the registries could explain this increase.
Garmendia, María Luisa
En: Am. J. Obstet. Gynecol., 2021.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey_92,
title = {The effects of a combined intervention (docosahexaenoic acid supplementation and home-based dietary counseling) on metabolic control in obese and overweight pregnant women: the MIGHT study.},
author = {María Luisa Garmendia},
doi = {10.1016/j.ajog.2020.10.048},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Am. J. Obstet. Gynecol.},
abstract = {- Otros autores: Casanello P, Flores M, Kusanovic JP, Uauy R.
- Cómo citar: Casanello P, Flores M, Kusanovic JP, Uauy R. The effects of a combined intervention (docosahexaenoic acid supplementation and home-based dietary counseling) on metabolic control in obese and overweight pregnant women: the MIGHT study. Am. J. Obstet. Gynecol. 2021;S0002-9378(20):31278-3. doi: 10.1016/j.ajog.2020.10.048. PMID: 33152314. ISSN: 0002-9378. IF [JCR]: 10.693. Q1
-Resumen: Background: Lifestyle interventions have shown limited effectiveness in the prevention of gestational diabetes mellitus. The combination of lifestyle interventions with omega-3 polyunsaturated fatty acid supplementation could have a synergetic effect on maternal and offspring outcomes.
Objective: We evaluated the effects of docosahexaenoic acid supplementation among obese and overweight pregnant women (independently or combined with a dietary counseling intervention) on metabolic control in mothers and their offspring. Study design: This study was a randomized controlled trial with a 2×2 factorial design. The following inclusion criteria were used: <15 weeks of gestation; body mass index ≥25 kg/m2 at the first prenatal visit; singleton pregnancy; and 18 years of age or older. The recruited women (n=1002) were randomly allocated to 1 of the 4 parallel groups: Group 1: dietary counseling plus 800 mg/day of docosahexaenoic acid (n=250); Group 2: routine counseling plus 800 mg/day docosahexaenoic acid (n=252); Group 3: dietary counseling plus 200 mg/day docosahexaenoic acid (n=249); and Group 4: routine counseling plus 200 mg/day docosahexaenoic acid (n=251), considered as the reference group. The dietary intervention comprised 3 sessions, and it was focused on reducing the consumption of foods that most contributed to daily sugar intake. Primary outcomes were gestational diabetes mellitus defined according to the national guidelines; macrosomia (birthweight >4000 g); and neonatal insulin resistance (cord blood Homeostasis Model Assessment for Insulin Resistance ≥2.60), which was assessed in a subsample of 226 newborns. The analysis was by intention to treat and by efficacy. The trial was registered on ClinicalTrials.gov (NCT02574767).
Results: The overall incidence of gestational diabetes mellitus was 20.2% (Group 1, 21.0%; Group 2, 20.1%; Group 3, 18.9%; and Group 4, 20.9%). Mean birthweight was 3403.0 g (standard deviation, 575.3), and the incidence of macrosomia was 11.9% (Group 1, 13.2%; Group 2, 10.8%; Group 3, 11.5%; and Group 4, 12.1%). Median cord blood Homeostasis Model Assessment for Insulin Resistance was 0.9 (interquartile range, 0.6-1.7), and 10.2% showed cord blood insulin resistance (Group 1, 12.0%; Group 2, 12.0%; Group 3, 9.7%; and Group 4, 5.1%). No significant differences were found among groups regarding primary outcomes (P<.05). Glucose concentrations in the cord blood samples were lower in those adherents to the docosahexaenoic acid supplementation (P<.05).
Conclusion: For women who were overweight or obese at the beginning of pregnancy, this combined intervention did not reduce the risk of gestational diabetes in mothers or macrosomia and insulin resistance in neonates.},
keywords = { L4: Ventanas Críticas del Desarrollo: Materno-Infantil. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Casanello P, Flores M, Kusanovic JP, Uauy R.
- Cómo citar: Casanello P, Flores M, Kusanovic JP, Uauy R. The effects of a combined intervention (docosahexaenoic acid supplementation and home-based dietary counseling) on metabolic control in obese and overweight pregnant women: the MIGHT study. Am. J. Obstet. Gynecol. 2021;S0002-9378(20):31278-3. doi: 10.1016/j.ajog.2020.10.048. PMID: 33152314. ISSN: 0002-9378. IF [JCR]: 10.693. Q1
-Resumen: Background: Lifestyle interventions have shown limited effectiveness in the prevention of gestational diabetes mellitus. The combination of lifestyle interventions with omega-3 polyunsaturated fatty acid supplementation could have a synergetic effect on maternal and offspring outcomes.
Objective: We evaluated the effects of docosahexaenoic acid supplementation among obese and overweight pregnant women (independently or combined with a dietary counseling intervention) on metabolic control in mothers and their offspring. Study design: This study was a randomized controlled trial with a 2×2 factorial design. The following inclusion criteria were used: <15 weeks of gestation; body mass index ≥25 kg/m2 at the first prenatal visit; singleton pregnancy; and 18 years of age or older. The recruited women (n=1002) were randomly allocated to 1 of the 4 parallel groups: Group 1: dietary counseling plus 800 mg/day of docosahexaenoic acid (n=250); Group 2: routine counseling plus 800 mg/day docosahexaenoic acid (n=252); Group 3: dietary counseling plus 200 mg/day docosahexaenoic acid (n=249); and Group 4: routine counseling plus 200 mg/day docosahexaenoic acid (n=251), considered as the reference group. The dietary intervention comprised 3 sessions, and it was focused on reducing the consumption of foods that most contributed to daily sugar intake. Primary outcomes were gestational diabetes mellitus defined according to the national guidelines; macrosomia (birthweight >4000 g); and neonatal insulin resistance (cord blood Homeostasis Model Assessment for Insulin Resistance ≥2.60), which was assessed in a subsample of 226 newborns. The analysis was by intention to treat and by efficacy. The trial was registered on ClinicalTrials.gov (NCT02574767).
Results: The overall incidence of gestational diabetes mellitus was 20.2% (Group 1, 21.0%; Group 2, 20.1%; Group 3, 18.9%; and Group 4, 20.9%). Mean birthweight was 3403.0 g (standard deviation, 575.3), and the incidence of macrosomia was 11.9% (Group 1, 13.2%; Group 2, 10.8%; Group 3, 11.5%; and Group 4, 12.1%). Median cord blood Homeostasis Model Assessment for Insulin Resistance was 0.9 (interquartile range, 0.6-1.7), and 10.2% showed cord blood insulin resistance (Group 1, 12.0%; Group 2, 12.0%; Group 3, 9.7%; and Group 4, 5.1%). No significant differences were found among groups regarding primary outcomes (P<.05). Glucose concentrations in the cord blood samples were lower in those adherents to the docosahexaenoic acid supplementation (P<.05).
Conclusion: For women who were overweight or obese at the beginning of pregnancy, this combined intervention did not reduce the risk of gestational diabetes in mothers or macrosomia and insulin resistance in neonates.
- Cómo citar: Casanello P, Flores M, Kusanovic JP, Uauy R. The effects of a combined intervention (docosahexaenoic acid supplementation and home-based dietary counseling) on metabolic control in obese and overweight pregnant women: the MIGHT study. Am. J. Obstet. Gynecol. 2021;S0002-9378(20):31278-3. doi: 10.1016/j.ajog.2020.10.048. PMID: 33152314. ISSN: 0002-9378. IF [JCR]: 10.693. Q1
-Resumen: Background: Lifestyle interventions have shown limited effectiveness in the prevention of gestational diabetes mellitus. The combination of lifestyle interventions with omega-3 polyunsaturated fatty acid supplementation could have a synergetic effect on maternal and offspring outcomes.
Objective: We evaluated the effects of docosahexaenoic acid supplementation among obese and overweight pregnant women (independently or combined with a dietary counseling intervention) on metabolic control in mothers and their offspring. Study design: This study was a randomized controlled trial with a 2×2 factorial design. The following inclusion criteria were used: <15 weeks of gestation; body mass index ≥25 kg/m2 at the first prenatal visit; singleton pregnancy; and 18 years of age or older. The recruited women (n=1002) were randomly allocated to 1 of the 4 parallel groups: Group 1: dietary counseling plus 800 mg/day of docosahexaenoic acid (n=250); Group 2: routine counseling plus 800 mg/day docosahexaenoic acid (n=252); Group 3: dietary counseling plus 200 mg/day docosahexaenoic acid (n=249); and Group 4: routine counseling plus 200 mg/day docosahexaenoic acid (n=251), considered as the reference group. The dietary intervention comprised 3 sessions, and it was focused on reducing the consumption of foods that most contributed to daily sugar intake. Primary outcomes were gestational diabetes mellitus defined according to the national guidelines; macrosomia (birthweight >4000 g); and neonatal insulin resistance (cord blood Homeostasis Model Assessment for Insulin Resistance ≥2.60), which was assessed in a subsample of 226 newborns. The analysis was by intention to treat and by efficacy. The trial was registered on ClinicalTrials.gov (NCT02574767).
Results: The overall incidence of gestational diabetes mellitus was 20.2% (Group 1, 21.0%; Group 2, 20.1%; Group 3, 18.9%; and Group 4, 20.9%). Mean birthweight was 3403.0 g (standard deviation, 575.3), and the incidence of macrosomia was 11.9% (Group 1, 13.2%; Group 2, 10.8%; Group 3, 11.5%; and Group 4, 12.1%). Median cord blood Homeostasis Model Assessment for Insulin Resistance was 0.9 (interquartile range, 0.6-1.7), and 10.2% showed cord blood insulin resistance (Group 1, 12.0%; Group 2, 12.0%; Group 3, 9.7%; and Group 4, 5.1%). No significant differences were found among groups regarding primary outcomes (P<.05). Glucose concentrations in the cord blood samples were lower in those adherents to the docosahexaenoic acid supplementation (P<.05).
Conclusion: For women who were overweight or obese at the beginning of pregnancy, this combined intervention did not reduce the risk of gestational diabetes in mothers or macrosomia and insulin resistance in neonates.