Publicaciones académicas
Filtrar por línea de investigación:
2023
Garmendia, María Luisa
Latin America and the Caribbean Code Against Cancer 1st Edition: 17 cancer prevention recommendations to the public and to policy-makers (World Code Against Cancer Framework) Artículo de revista
En: Cancer Epidemiol. , 2023.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Latin America and the Caribbean Code Against Cancer 1st Edition: 17 cancer prevention recommendations to the public and to policy-makers (World Code Against Cancer Framework)},
author = {María Luisa Garmendia},
doi = {10.1016/j.canep.2023.102402},
year = {2023},
date = {2023-11-20},
urldate = {2023-11-20},
journal = {Cancer Epidemiol. },
abstract = {- Otros autores: Espina, C., Feliu, A., Maza, M., Almonte, M., Ferreccio, C., Finck, C., Herrero, R., Dommarco, J. R., de Almeida, L. M., Arrossi, S., García, P. J., Garmendia, M. L., Mohar, A., Murillo, R., Santamaría, J., Tortolero-Luna, G., Cazap, E., Gabriel, O. O., Paonessa, D., Zoss, J.
- Cómo citar: Espina, C., Feliu, A., Maza, M., Almonte, M., Ferreccio, C., Finck, C., Herrero, R., Dommarco, J. R., de Almeida, L. M., Arrossi, S., García, P. J., Garmendia, M. L., Mohar, A., Murillo, R., Santamaría, J., Tortolero-Luna, G., Cazap, E., Gabriel, O. O., Paonessa, D., Zoss, J. W., … Working Groups of Scientific Experts (2023). Latin America and the Caribbean Code Against Cancer 1st Edition: 17 cancer prevention recommendations to the public and to policy-makers (World Code Against Cancer Framework). Cancer epidemiology, 86 Suppl 1, 102402. https://doi.org/10.1016/j.canep.2023.102402.
- Resumen: Preventable risk factors are responsible of at least 40% of cases and almost 45% of all cancer deaths worldwide. Cancer is already the leading cause of death in almost half of the Latin American and the Caribbean countries constituting a public health problem. Cost-effective measures to reduce exposures through primary prevention and screening of certain types of cancers are critical in the fight against cancer but need to be tailored to the local needs and scenarios. The Latin America and the Caribbean (LAC) Code Against Cancer, 1st edition, consists of 17 evidence-based recommendations for the general public, based on the most recent solid evidence on lifestyle, environmental, occupational, and infectious risk factors, and medical interventions. Each recommendation is accompanied by recommendations for policymakers to guide governments establishing the infrastructure needed to enable the public adopting the recommendations. The LAC Code Against Cancer has been developed in a collaborative effort by a large number of experts from the region, under the umbrella strategy and authoritative methodology of the World Code Against Cancer Framework. The Code is a structured instrument ideal for cancer prevention and control that aims to raise awareness and educate the public, while building capacity and competencies to policymakers, health professionals, stakeholders, to contribute to reduce the burden of cancer in LAC.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Espina, C., Feliu, A., Maza, M., Almonte, M., Ferreccio, C., Finck, C., Herrero, R., Dommarco, J. R., de Almeida, L. M., Arrossi, S., García, P. J., Garmendia, M. L., Mohar, A., Murillo, R., Santamaría, J., Tortolero-Luna, G., Cazap, E., Gabriel, O. O., Paonessa, D., Zoss, J.
- Cómo citar: Espina, C., Feliu, A., Maza, M., Almonte, M., Ferreccio, C., Finck, C., Herrero, R., Dommarco, J. R., de Almeida, L. M., Arrossi, S., García, P. J., Garmendia, M. L., Mohar, A., Murillo, R., Santamaría, J., Tortolero-Luna, G., Cazap, E., Gabriel, O. O., Paonessa, D., Zoss, J. W., … Working Groups of Scientific Experts (2023). Latin America and the Caribbean Code Against Cancer 1st Edition: 17 cancer prevention recommendations to the public and to policy-makers (World Code Against Cancer Framework). Cancer epidemiology, 86 Suppl 1, 102402. https://doi.org/10.1016/j.canep.2023.102402.
- Resumen: Preventable risk factors are responsible of at least 40% of cases and almost 45% of all cancer deaths worldwide. Cancer is already the leading cause of death in almost half of the Latin American and the Caribbean countries constituting a public health problem. Cost-effective measures to reduce exposures through primary prevention and screening of certain types of cancers are critical in the fight against cancer but need to be tailored to the local needs and scenarios. The Latin America and the Caribbean (LAC) Code Against Cancer, 1st edition, consists of 17 evidence-based recommendations for the general public, based on the most recent solid evidence on lifestyle, environmental, occupational, and infectious risk factors, and medical interventions. Each recommendation is accompanied by recommendations for policymakers to guide governments establishing the infrastructure needed to enable the public adopting the recommendations. The LAC Code Against Cancer has been developed in a collaborative effort by a large number of experts from the region, under the umbrella strategy and authoritative methodology of the World Code Against Cancer Framework. The Code is a structured instrument ideal for cancer prevention and control that aims to raise awareness and educate the public, while building capacity and competencies to policymakers, health professionals, stakeholders, to contribute to reduce the burden of cancer in LAC.
- Cómo citar: Espina, C., Feliu, A., Maza, M., Almonte, M., Ferreccio, C., Finck, C., Herrero, R., Dommarco, J. R., de Almeida, L. M., Arrossi, S., García, P. J., Garmendia, M. L., Mohar, A., Murillo, R., Santamaría, J., Tortolero-Luna, G., Cazap, E., Gabriel, O. O., Paonessa, D., Zoss, J. W., … Working Groups of Scientific Experts (2023). Latin America and the Caribbean Code Against Cancer 1st Edition: 17 cancer prevention recommendations to the public and to policy-makers (World Code Against Cancer Framework). Cancer epidemiology, 86 Suppl 1, 102402. https://doi.org/10.1016/j.canep.2023.102402.
- Resumen: Preventable risk factors are responsible of at least 40% of cases and almost 45% of all cancer deaths worldwide. Cancer is already the leading cause of death in almost half of the Latin American and the Caribbean countries constituting a public health problem. Cost-effective measures to reduce exposures through primary prevention and screening of certain types of cancers are critical in the fight against cancer but need to be tailored to the local needs and scenarios. The Latin America and the Caribbean (LAC) Code Against Cancer, 1st edition, consists of 17 evidence-based recommendations for the general public, based on the most recent solid evidence on lifestyle, environmental, occupational, and infectious risk factors, and medical interventions. Each recommendation is accompanied by recommendations for policymakers to guide governments establishing the infrastructure needed to enable the public adopting the recommendations. The LAC Code Against Cancer has been developed in a collaborative effort by a large number of experts from the region, under the umbrella strategy and authoritative methodology of the World Code Against Cancer Framework. The Code is a structured instrument ideal for cancer prevention and control that aims to raise awareness and educate the public, while building capacity and competencies to policymakers, health professionals, stakeholders, to contribute to reduce the burden of cancer in LAC.
Corvalán, Camila
Latin America and the Caribbean Code Against Cancer 1st edition: Tobacco and nicotine-related products, secondhand smoke, and alcohol and cancer Artículo de revista
En: Cancer Epidemiol., 2023.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Latin America and the Caribbean Code Against Cancer 1st edition: Tobacco and nicotine-related products, secondhand smoke, and alcohol and cancer},
author = {Camila Corvalán },
doi = {10.1016/j.canep.2023.102413},
year = {2023},
date = {2023-11-20},
urldate = {2023-11-20},
journal = {Cancer Epidemiol.},
abstract = {- Otros autores: Reynales-Shigematsu LM, Barnoya J, Cavalcante T, Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Canelo-Aybar C, Alvarado-Villacorta R, Espina C, Feliu A, Rivera JA.
- Cómo citar: Reynales-Shigematsu LM, Barnoya J, Cavalcante T, Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Canelo-Aybar C, Alvarado-Villacorta R, Espina C, Feliu A, Rivera JA. Latin America and the Caribbean Code Against Cancer 1st edition: Tobacco and nicotine-related products, secondhand smoke, and alcohol and cancer. Cancer Epidemiol. 2023;86:102413. doi: 10.1016/j.canep.2023.102413. PMID: 37852726. ISSN: 1877-7821. IF [JCR]: 2.6. Q3.
- Resumen: Tobacco, secondhand smoke (SHS), and alcohol, all carcinogens, are leading preventable cancer risk factors in Latin America and the Caribbean (LAC). Since 2000, smoking and SHS exposure have significantly decreased in the region. Yet alcohol consumption remains high. The entry of nicotine-related products such as electronic cigarettes (e-cigs) threatens achievements made in tobacco control and chronic diseases prevention, including cancer. E-cigs use is likely associated with smoking initiation among adolescents who had never smoked and dual use with combustible tobacco products. Therefore, the LAC Code Against Cancer recommends to the public actions they can take to reduce their risk of cancer: 1. Don't smoke or use any type of tobacco. If you do, quitting is possible, with professional help if needed. Don't use e-cigarettes either, as they lead to tobacco use. 2. Make your home a smoke-free place. Respect and promote laws that ensure smoke-free spaces to protect our health. and 3. Avoid drinking alcoholic beverages. This helps prevent several types of cancer. The Code recommends to policymakers a package of cost-effective policies based on the MPOWER and SAFER to prevent cancer at the population level. It also recommends that primary care health professionals: 1. Ask all their patients and their families whether they smoke or vape, inform them about the harms of smoking and vaping, and promote tobacco and nicotine related products cessation strategies among users. 2. Inform about the harms of exposure to SHS, especially among children, and promote smoke-free environments, and 3. Prevent alcohol use by their patients and their families, use tools to assess use, intensity, and frequency, and apply brief counseling intervention to support alcohol abstinence in primary care.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Reynales-Shigematsu LM, Barnoya J, Cavalcante T, Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Canelo-Aybar C, Alvarado-Villacorta R, Espina C, Feliu A, Rivera JA.
- Cómo citar: Reynales-Shigematsu LM, Barnoya J, Cavalcante T, Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Canelo-Aybar C, Alvarado-Villacorta R, Espina C, Feliu A, Rivera JA. Latin America and the Caribbean Code Against Cancer 1st edition: Tobacco and nicotine-related products, secondhand smoke, and alcohol and cancer. Cancer Epidemiol. 2023;86:102413. doi: 10.1016/j.canep.2023.102413. PMID: 37852726. ISSN: 1877-7821. IF [JCR]: 2.6. Q3.
- Resumen: Tobacco, secondhand smoke (SHS), and alcohol, all carcinogens, are leading preventable cancer risk factors in Latin America and the Caribbean (LAC). Since 2000, smoking and SHS exposure have significantly decreased in the region. Yet alcohol consumption remains high. The entry of nicotine-related products such as electronic cigarettes (e-cigs) threatens achievements made in tobacco control and chronic diseases prevention, including cancer. E-cigs use is likely associated with smoking initiation among adolescents who had never smoked and dual use with combustible tobacco products. Therefore, the LAC Code Against Cancer recommends to the public actions they can take to reduce their risk of cancer: 1. Don't smoke or use any type of tobacco. If you do, quitting is possible, with professional help if needed. Don't use e-cigarettes either, as they lead to tobacco use. 2. Make your home a smoke-free place. Respect and promote laws that ensure smoke-free spaces to protect our health. and 3. Avoid drinking alcoholic beverages. This helps prevent several types of cancer. The Code recommends to policymakers a package of cost-effective policies based on the MPOWER and SAFER to prevent cancer at the population level. It also recommends that primary care health professionals: 1. Ask all their patients and their families whether they smoke or vape, inform them about the harms of smoking and vaping, and promote tobacco and nicotine related products cessation strategies among users. 2. Inform about the harms of exposure to SHS, especially among children, and promote smoke-free environments, and 3. Prevent alcohol use by their patients and their families, use tools to assess use, intensity, and frequency, and apply brief counseling intervention to support alcohol abstinence in primary care.
- Cómo citar: Reynales-Shigematsu LM, Barnoya J, Cavalcante T, Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Canelo-Aybar C, Alvarado-Villacorta R, Espina C, Feliu A, Rivera JA. Latin America and the Caribbean Code Against Cancer 1st edition: Tobacco and nicotine-related products, secondhand smoke, and alcohol and cancer. Cancer Epidemiol. 2023;86:102413. doi: 10.1016/j.canep.2023.102413. PMID: 37852726. ISSN: 1877-7821. IF [JCR]: 2.6. Q3.
- Resumen: Tobacco, secondhand smoke (SHS), and alcohol, all carcinogens, are leading preventable cancer risk factors in Latin America and the Caribbean (LAC). Since 2000, smoking and SHS exposure have significantly decreased in the region. Yet alcohol consumption remains high. The entry of nicotine-related products such as electronic cigarettes (e-cigs) threatens achievements made in tobacco control and chronic diseases prevention, including cancer. E-cigs use is likely associated with smoking initiation among adolescents who had never smoked and dual use with combustible tobacco products. Therefore, the LAC Code Against Cancer recommends to the public actions they can take to reduce their risk of cancer: 1. Don't smoke or use any type of tobacco. If you do, quitting is possible, with professional help if needed. Don't use e-cigarettes either, as they lead to tobacco use. 2. Make your home a smoke-free place. Respect and promote laws that ensure smoke-free spaces to protect our health. and 3. Avoid drinking alcoholic beverages. This helps prevent several types of cancer. The Code recommends to policymakers a package of cost-effective policies based on the MPOWER and SAFER to prevent cancer at the population level. It also recommends that primary care health professionals: 1. Ask all their patients and their families whether they smoke or vape, inform them about the harms of smoking and vaping, and promote tobacco and nicotine related products cessation strategies among users. 2. Inform about the harms of exposure to SHS, especially among children, and promote smoke-free environments, and 3. Prevent alcohol use by their patients and their families, use tools to assess use, intensity, and frequency, and apply brief counseling intervention to support alcohol abstinence in primary care.
Corvalán, Camila
Latin American and the Caribbean Code Against Cancer 1st edition: Weight, physical activity, diet, breastfeeding, and cancer Artículo de revista
En: Cancer Epidemiol., 2023.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Latin American and the Caribbean Code Against Cancer 1st edition: Weight, physical activity, diet, breastfeeding, and cancer},
author = {Camila Corvalán},
doi = {10.1016/j.canep.2023.102436},
year = {2023},
date = {2023-11-20},
urldate = {2023-11-20},
journal = {Cancer Epidemiol.},
abstract = {- Otros autores: Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Reynales-Shigematsu LM, Barnoya J, Cavalcante TM, Canelo-Aybar C, Santero M, Feliu A, Espina C, Rivera JA.
- Cómo citar: Aburto, T. C., Romieu, I., Stern, M. C., Barquera, S., Corvalán, C., Hallal, P. C., Reynales-Shigematsu, L. M., Barnoya, J., Cavalcante, T. M., Canelo-Aybar, C., Santero, M., Feliu, A., Espina, C., & Rivera, J. A. (2023). Latin American and the Caribbean Code Against Cancer 1st edition: Weight, physical activity, diet, breastfeeding, and cancer. Cancer epidemiology, 86 Suppl 1, 102436. https://doi.org/10.1016/j.canep.2023.102436.
- Resumen: In Latin America and the Caribbean a considerable proportion of the population have excess body weight, do not meet the recommendations of physical activity and healthy diet, and have suboptimal rates of breastfeeding. Excess body weight is associated with at least 15 cancer sites, physical activity protects against three cancers, with some evidence suggesting a protective effect for eight more cancer sites, and sedentary behavior probably increases the risk of five cancer sites. Fiber and wholegrains protect against colorectal cancer, high intake of fruits and vegetables could reduce the risk of aerodigestive cancers; processed and red meat increase the risk of colorectal cancer; and very hot beverages are associated with esophageal cancer. Moreover, sugar-sweetened beverages and ultra-processed foods are a convincing cause for excess body weight, increasing cancer risk through this pathway, with some emerging evidence suggesting also direct pathways. Breastfeeding protects against breast cancer, and could protect against ovarian cancer. Taking this evidence into account, the Latin America and the Caribbean Code Against Cancer recommends the general public to maintain a healthy body weight, be physically active and limit sedentary behavior, eat a healthy diet (eat plenty of vegetables, fruits, wholegrains and legumes; avoid sugar-sweetened beverages and processed meat; and limit ultra-processed foods, red meat and very hot beverages), and breastfeed. Moreover, the Latin America and the Caribbean Code Against Cancer also includes a set of public policy recommendations for cancer prevention to inform policy makers and civil society about the need of policies to shape healthy environments and create opportunities to facilitate the adoption of the recommendations directed to the public.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Aburto TC, Romieu I, Stern MC, Barquera S, Corvalán C, Hallal PC, Reynales-Shigematsu LM, Barnoya J, Cavalcante TM, Canelo-Aybar C, Santero M, Feliu A, Espina C, Rivera JA.
- Cómo citar: Aburto, T. C., Romieu, I., Stern, M. C., Barquera, S., Corvalán, C., Hallal, P. C., Reynales-Shigematsu, L. M., Barnoya, J., Cavalcante, T. M., Canelo-Aybar, C., Santero, M., Feliu, A., Espina, C., & Rivera, J. A. (2023). Latin American and the Caribbean Code Against Cancer 1st edition: Weight, physical activity, diet, breastfeeding, and cancer. Cancer epidemiology, 86 Suppl 1, 102436. https://doi.org/10.1016/j.canep.2023.102436.
- Resumen: In Latin America and the Caribbean a considerable proportion of the population have excess body weight, do not meet the recommendations of physical activity and healthy diet, and have suboptimal rates of breastfeeding. Excess body weight is associated with at least 15 cancer sites, physical activity protects against three cancers, with some evidence suggesting a protective effect for eight more cancer sites, and sedentary behavior probably increases the risk of five cancer sites. Fiber and wholegrains protect against colorectal cancer, high intake of fruits and vegetables could reduce the risk of aerodigestive cancers; processed and red meat increase the risk of colorectal cancer; and very hot beverages are associated with esophageal cancer. Moreover, sugar-sweetened beverages and ultra-processed foods are a convincing cause for excess body weight, increasing cancer risk through this pathway, with some emerging evidence suggesting also direct pathways. Breastfeeding protects against breast cancer, and could protect against ovarian cancer. Taking this evidence into account, the Latin America and the Caribbean Code Against Cancer recommends the general public to maintain a healthy body weight, be physically active and limit sedentary behavior, eat a healthy diet (eat plenty of vegetables, fruits, wholegrains and legumes; avoid sugar-sweetened beverages and processed meat; and limit ultra-processed foods, red meat and very hot beverages), and breastfeed. Moreover, the Latin America and the Caribbean Code Against Cancer also includes a set of public policy recommendations for cancer prevention to inform policy makers and civil society about the need of policies to shape healthy environments and create opportunities to facilitate the adoption of the recommendations directed to the public.
- Cómo citar: Aburto, T. C., Romieu, I., Stern, M. C., Barquera, S., Corvalán, C., Hallal, P. C., Reynales-Shigematsu, L. M., Barnoya, J., Cavalcante, T. M., Canelo-Aybar, C., Santero, M., Feliu, A., Espina, C., & Rivera, J. A. (2023). Latin American and the Caribbean Code Against Cancer 1st edition: Weight, physical activity, diet, breastfeeding, and cancer. Cancer epidemiology, 86 Suppl 1, 102436. https://doi.org/10.1016/j.canep.2023.102436.
- Resumen: In Latin America and the Caribbean a considerable proportion of the population have excess body weight, do not meet the recommendations of physical activity and healthy diet, and have suboptimal rates of breastfeeding. Excess body weight is associated with at least 15 cancer sites, physical activity protects against three cancers, with some evidence suggesting a protective effect for eight more cancer sites, and sedentary behavior probably increases the risk of five cancer sites. Fiber and wholegrains protect against colorectal cancer, high intake of fruits and vegetables could reduce the risk of aerodigestive cancers; processed and red meat increase the risk of colorectal cancer; and very hot beverages are associated with esophageal cancer. Moreover, sugar-sweetened beverages and ultra-processed foods are a convincing cause for excess body weight, increasing cancer risk through this pathway, with some emerging evidence suggesting also direct pathways. Breastfeeding protects against breast cancer, and could protect against ovarian cancer. Taking this evidence into account, the Latin America and the Caribbean Code Against Cancer recommends the general public to maintain a healthy body weight, be physically active and limit sedentary behavior, eat a healthy diet (eat plenty of vegetables, fruits, wholegrains and legumes; avoid sugar-sweetened beverages and processed meat; and limit ultra-processed foods, red meat and very hot beverages), and breastfeed. Moreover, the Latin America and the Caribbean Code Against Cancer also includes a set of public policy recommendations for cancer prevention to inform policy makers and civil society about the need of policies to shape healthy environments and create opportunities to facilitate the adoption of the recommendations directed to the public.
Corvalán, Camila; Pereira, Ana
Time-specific Impact of Mono-Benzyl Phthalate (MBzP) and Perfluorooctanoic Acid (PFOA) on Breast Density of Adolescent Latino Girls Artículo de revista
En: Environ. Int., 2023.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Time-specific Impact of Mono-Benzyl Phthalate (MBzP) and Perfluorooctanoic Acid (PFOA) on Breast Density of Adolescent Latino Girls},
author = {Camila Corvalán and Ana Pereira },
doi = {10.1016/j.envint.2023.108241},
year = {2023},
date = {2023-10-16},
urldate = {2023-10-16},
journal = {Environ. Int.},
abstract = {- Otros autores: Kim C, Binder A, Corvalán C, Pereira A, Shepherd J, Calafat A, Botelho J, Hampton J, Trentham-Dietz A, Michels KB.
- Cómo citar: Kim, C. E., Binder, A. M., Corvalan, C., Pereira, A., Shepherd, J., Calafat, A. M., Botelho, J. C., Hampton, J. M., Trentham-Dietz, A., & Michels, K. B. (2023). Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort. Environment international, 181, 108241. https://doi.org/10.1016/j.envint.2023.108241
- Resumen: Introduction: High mammographic density is among the strongest and most established predictors for breast cancer risk. Puberty, the period during which breasts undergo exponential mammary growth, is considered one of the critical stages of breast development for environmental exposures. Benzylbutyl phthalate (BBP) and perfluorooctanoic acid (PFOA) are pervasive endocrine disrupting chemicals that may increase hormone-sensitive cancers. Evaluating the potential impact of BBP and PFOA exposure on pubertal breast density is important to our understanding of early-life environmental influences on breast cancer etiology.
Objective: To prospectively assess the effect of biomarker concentrations of monobenzyl phthalate (MBzP) and PFOA at specific pubertal window of susceptibility (WOS) on adolescent breast density.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Kim C, Binder A, Corvalán C, Pereira A, Shepherd J, Calafat A, Botelho J, Hampton J, Trentham-Dietz A, Michels KB.
- Cómo citar: Kim, C. E., Binder, A. M., Corvalan, C., Pereira, A., Shepherd, J., Calafat, A. M., Botelho, J. C., Hampton, J. M., Trentham-Dietz, A., & Michels, K. B. (2023). Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort. Environment international, 181, 108241. https://doi.org/10.1016/j.envint.2023.108241
- Resumen: Introduction: High mammographic density is among the strongest and most established predictors for breast cancer risk. Puberty, the period during which breasts undergo exponential mammary growth, is considered one of the critical stages of breast development for environmental exposures. Benzylbutyl phthalate (BBP) and perfluorooctanoic acid (PFOA) are pervasive endocrine disrupting chemicals that may increase hormone-sensitive cancers. Evaluating the potential impact of BBP and PFOA exposure on pubertal breast density is important to our understanding of early-life environmental influences on breast cancer etiology.
Objective: To prospectively assess the effect of biomarker concentrations of monobenzyl phthalate (MBzP) and PFOA at specific pubertal window of susceptibility (WOS) on adolescent breast density.
- Cómo citar: Kim, C. E., Binder, A. M., Corvalan, C., Pereira, A., Shepherd, J., Calafat, A. M., Botelho, J. C., Hampton, J. M., Trentham-Dietz, A., & Michels, K. B. (2023). Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort. Environment international, 181, 108241. https://doi.org/10.1016/j.envint.2023.108241
- Resumen: Introduction: High mammographic density is among the strongest and most established predictors for breast cancer risk. Puberty, the period during which breasts undergo exponential mammary growth, is considered one of the critical stages of breast development for environmental exposures. Benzylbutyl phthalate (BBP) and perfluorooctanoic acid (PFOA) are pervasive endocrine disrupting chemicals that may increase hormone-sensitive cancers. Evaluating the potential impact of BBP and PFOA exposure on pubertal breast density is important to our understanding of early-life environmental influences on breast cancer etiology.
Objective: To prospectively assess the effect of biomarker concentrations of monobenzyl phthalate (MBzP) and PFOA at specific pubertal window of susceptibility (WOS) on adolescent breast density.
2022
Pereira, Ana
A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women. Artículo de revista
En: Sci Rep., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_55,
title = {A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women.},
author = {Ana Pereira},
doi = {10.1038/s41598-022-17800-0},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Sci Rep.},
abstract = {- Otros autores: Kehm RD, Walter EJ, White ML, Oskar S, Michels KB, Shepherd JA, Lilge L, Terry MB.
- Cómo citar: Kehm RD, Walter EJ, White ML, Oskar S, Michels KB, Shepherd JA, Lilge L, Terry MB. A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women. Sci Rep. 2022;12(1):13547. doi: 10.1038/s41598-022-17800-0. PMID: 35941279 PMCID: PMC9360013. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
- Resumen: This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (rpartial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (rpartial = 0.46},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Kehm RD, Walter EJ, White ML, Oskar S, Michels KB, Shepherd JA, Lilge L, Terry MB.
- Cómo citar: Kehm RD, Walter EJ, White ML, Oskar S, Michels KB, Shepherd JA, Lilge L, Terry MB. A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women. Sci Rep. 2022;12(1):13547. doi: 10.1038/s41598-022-17800-0. PMID: 35941279 PMCID: PMC9360013. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
- Resumen: This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (rpartial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (rpartial = 0.46
- Cómo citar: Kehm RD, Walter EJ, White ML, Oskar S, Michels KB, Shepherd JA, Lilge L, Terry MB. A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women. Sci Rep. 2022;12(1):13547. doi: 10.1038/s41598-022-17800-0. PMID: 35941279 PMCID: PMC9360013. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
- Resumen: This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (rpartial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (rpartial = 0.46
Garmendia, María Luisa
Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study. Artículo de revista
En: BMJ nutr. prev. health., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_70,
title = {Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study.},
author = {María Luisa Garmendia},
doi = {10.1136/bmjnph-2021-000335},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {BMJ nutr. prev. health.},
abstract = {- Otros autores: Romieu I, Khandpur N, Katsikari A, Biessy C, Torres-Mejía G, Ángeles-Larenas A, Alvarado-Cabrero I, Sánchez GI, Maldonado ME, Porras C, Rodríguez AC, Chajés V, Aglago EK, Porter PL, Lin M, His M, Gunter MJ, Huybrechts I, Rinaldi S, PRECAMA team.
- Cómo citar: Romieu I, Khandpur N, Katsikari A, Biessy C, Torres-Mejía G, Ángeles-Larenas A, Alvarado-Cabrero I, Sánchez GI, Maldonado ME, Porras C, Rodríguez AC, Chajés V, Aglago EK, Porter PL, Lin M, His M, Gunter MJ, Huybrechts I, Rinaldi S, PRECAMA team. Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study. BMJ nutr. prev. health. 2022;5(1):1-9. doi: 10.1136/bmjnph-2021-000335. PMID: 35814719. PMCID: PMC9237890. ISSN: 2516-5542. IF [SJR]: 0.416. Q3
-Resumen: Ultra-processed food intake has been linked to an increased risk of breast cancer in Western populations. No data are available in the Latin American population although the consumption of ultra-processed foods is increasing rapidly in this region. We evaluated the association of ultra-processed food intake to breast cancer risk in a case-control study including 525 cases (women aged 20-45 years) and 525 matched population-based controls from Chile, Colombia, Costa Rica and Mexico. The degree of processing of foods was classified according to the NOVA classification. Overall, the major contributors to ultra-processed food intake were ready-to-eat/heat foods (18.2%), cakes and desserts (16.7%), carbonated and industrial fruit juice beverages (16.7%), breakfast cereals (12.9%), sausages and reconstituted meat products (12.1%), industrial bread (6.1%), dairy products and derivatives (7.6%) and package savoury snacks (6.1%). Ultra-processed food intake was positively associated with the risk of breast cancer in adjusted models (OR T3-T1=1.93; 95% CI=1.11 to 3.35). Specifically, a higher risk was observed with oestrogen receptor positive breast cancer (ORT3-T1=2.44, (95% CI=1.01 to 5.90},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Romieu I, Khandpur N, Katsikari A, Biessy C, Torres-Mejía G, Ángeles-Larenas A, Alvarado-Cabrero I, Sánchez GI, Maldonado ME, Porras C, Rodríguez AC, Chajés V, Aglago EK, Porter PL, Lin M, His M, Gunter MJ, Huybrechts I, Rinaldi S, PRECAMA team.
- Cómo citar: Romieu I, Khandpur N, Katsikari A, Biessy C, Torres-Mejía G, Ángeles-Larenas A, Alvarado-Cabrero I, Sánchez GI, Maldonado ME, Porras C, Rodríguez AC, Chajés V, Aglago EK, Porter PL, Lin M, His M, Gunter MJ, Huybrechts I, Rinaldi S, PRECAMA team. Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study. BMJ nutr. prev. health. 2022;5(1):1-9. doi: 10.1136/bmjnph-2021-000335. PMID: 35814719. PMCID: PMC9237890. ISSN: 2516-5542. IF [SJR]: 0.416. Q3
-Resumen: Ultra-processed food intake has been linked to an increased risk of breast cancer in Western populations. No data are available in the Latin American population although the consumption of ultra-processed foods is increasing rapidly in this region. We evaluated the association of ultra-processed food intake to breast cancer risk in a case-control study including 525 cases (women aged 20-45 years) and 525 matched population-based controls from Chile, Colombia, Costa Rica and Mexico. The degree of processing of foods was classified according to the NOVA classification. Overall, the major contributors to ultra-processed food intake were ready-to-eat/heat foods (18.2%), cakes and desserts (16.7%), carbonated and industrial fruit juice beverages (16.7%), breakfast cereals (12.9%), sausages and reconstituted meat products (12.1%), industrial bread (6.1%), dairy products and derivatives (7.6%) and package savoury snacks (6.1%). Ultra-processed food intake was positively associated with the risk of breast cancer in adjusted models (OR T3-T1=1.93; 95% CI=1.11 to 3.35). Specifically, a higher risk was observed with oestrogen receptor positive breast cancer (ORT3-T1=2.44, (95% CI=1.01 to 5.90
- Cómo citar: Romieu I, Khandpur N, Katsikari A, Biessy C, Torres-Mejía G, Ángeles-Larenas A, Alvarado-Cabrero I, Sánchez GI, Maldonado ME, Porras C, Rodríguez AC, Chajés V, Aglago EK, Porter PL, Lin M, His M, Gunter MJ, Huybrechts I, Rinaldi S, PRECAMA team. Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study. BMJ nutr. prev. health. 2022;5(1):1-9. doi: 10.1136/bmjnph-2021-000335. PMID: 35814719. PMCID: PMC9237890. ISSN: 2516-5542. IF [SJR]: 0.416. Q3
-Resumen: Ultra-processed food intake has been linked to an increased risk of breast cancer in Western populations. No data are available in the Latin American population although the consumption of ultra-processed foods is increasing rapidly in this region. We evaluated the association of ultra-processed food intake to breast cancer risk in a case-control study including 525 cases (women aged 20-45 years) and 525 matched population-based controls from Chile, Colombia, Costa Rica and Mexico. The degree of processing of foods was classified according to the NOVA classification. Overall, the major contributors to ultra-processed food intake were ready-to-eat/heat foods (18.2%), cakes and desserts (16.7%), carbonated and industrial fruit juice beverages (16.7%), breakfast cereals (12.9%), sausages and reconstituted meat products (12.1%), industrial bread (6.1%), dairy products and derivatives (7.6%) and package savoury snacks (6.1%). Ultra-processed food intake was positively associated with the risk of breast cancer in adjusted models (OR T3-T1=1.93; 95% CI=1.11 to 3.35). Specifically, a higher risk was observed with oestrogen receptor positive breast cancer (ORT3-T1=2.44, (95% CI=1.01 to 5.90
Reyes, Marcela; Garmendia, María Luisa; Corvalán, Camila; Pereira, Ana
Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset. Artículo de revista
En: Cancer Epidemiol. Biomarkers Prev., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_65,
title = {Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset.},
author = {Marcela Reyes and María Luisa Garmendia and Camila Corvalán and Ana Pereira},
doi = {10.1158/1055-9965.EPI-22-0016},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Cancer Epidemiol. Biomarkers Prev.},
abstract = {- Otros autores: Lesser C, Mericq V, Shepherd JA, Michels KB.
- Cómo citar: Lesser C, Mericq V, Shepherd JA, Michels KB. Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset. Cancer Epidemiol. Biomarkers Prev. 2022;31(7): 1334–1340. doi: 10.1158/1055-9965.EPI-22-0016. PMID: 35477112 PMCID: PMC9250624. ISSN: 1055-9965. IF [JCR]: 4.090. Q2
-Resumen: "Background: High phytoestrogen intake during adolescence is associated with a reduced risk of breast cancer. Breast density (BD) is a strong predictor of breast cancer and can be considered an early marker. We aim to assess the association between the mean habitual intake of isoflavones, lignans, and total phytoestrogens intake during puberty until 2 years after menarche onset and absolute fibroglandular volume (AFGV) and percentage of fibroglandular volume (%FGV) in Hispanic girls at the end of puberty.
Methods: Longitudinal study set up in the Growth and Obesity Chilean Cohort Study (GOCS). We included 329 girls with dietary data (multiple 24-hours recalls) from puberty until 2 years after menarche onset (81% had 2-4 recalls). Two international datasets were used to estimate isoflavones, lignans, and total phytoestrogens in the diet. Breast composition was measured by dual energy X-ray absorptiometry at 2 years after menarche. Multiple linear regression models were used to assess the association between isoflavones, lignans, and total phytoestrogens intake and AFGV and %FGV. Results: The average total phytoestrogen intake was 1 mg/day and %FGV was 50.7% (SD = 15.2) and AFGV 218.8 cm3 (SD = 79.3). An inverse association was found between consumption of isoflavones and AFGV, as well as, with total phytoestrogens [Q4 vs. Q1 adjusted model ß = -49.2 cm3; 95% CI (-85.5 to -13.0)].
Conclusions: Girls with a higher intake of total phytoestrogens and isoflavones during puberty until 2 years after menarche onset had significantly lower AFGV.
Impact: Although the intake of phytoestrogens is low in Western populations, higher consumption of them during a critical period of life like puberty could be beneficial to reduce breast cancer during adulthood."},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Lesser C, Mericq V, Shepherd JA, Michels KB.
- Cómo citar: Lesser C, Mericq V, Shepherd JA, Michels KB. Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset. Cancer Epidemiol. Biomarkers Prev. 2022;31(7): 1334–1340. doi: 10.1158/1055-9965.EPI-22-0016. PMID: 35477112 PMCID: PMC9250624. ISSN: 1055-9965. IF [JCR]: 4.090. Q2
-Resumen: "Background: High phytoestrogen intake during adolescence is associated with a reduced risk of breast cancer. Breast density (BD) is a strong predictor of breast cancer and can be considered an early marker. We aim to assess the association between the mean habitual intake of isoflavones, lignans, and total phytoestrogens intake during puberty until 2 years after menarche onset and absolute fibroglandular volume (AFGV) and percentage of fibroglandular volume (%FGV) in Hispanic girls at the end of puberty.
Methods: Longitudinal study set up in the Growth and Obesity Chilean Cohort Study (GOCS). We included 329 girls with dietary data (multiple 24-hours recalls) from puberty until 2 years after menarche onset (81% had 2-4 recalls). Two international datasets were used to estimate isoflavones, lignans, and total phytoestrogens in the diet. Breast composition was measured by dual energy X-ray absorptiometry at 2 years after menarche. Multiple linear regression models were used to assess the association between isoflavones, lignans, and total phytoestrogens intake and AFGV and %FGV. Results: The average total phytoestrogen intake was 1 mg/day and %FGV was 50.7% (SD = 15.2) and AFGV 218.8 cm3 (SD = 79.3). An inverse association was found between consumption of isoflavones and AFGV, as well as, with total phytoestrogens [Q4 vs. Q1 adjusted model ß = -49.2 cm3; 95% CI (-85.5 to -13.0)].
Conclusions: Girls with a higher intake of total phytoestrogens and isoflavones during puberty until 2 years after menarche onset had significantly lower AFGV.
Impact: Although the intake of phytoestrogens is low in Western populations, higher consumption of them during a critical period of life like puberty could be beneficial to reduce breast cancer during adulthood."
- Cómo citar: Lesser C, Mericq V, Shepherd JA, Michels KB. Habitual Phytoestrogen Intake is Associated with Breast Composition in Girls at 2 Years after Menarche Onset. Cancer Epidemiol. Biomarkers Prev. 2022;31(7): 1334–1340. doi: 10.1158/1055-9965.EPI-22-0016. PMID: 35477112 PMCID: PMC9250624. ISSN: 1055-9965. IF [JCR]: 4.090. Q2
-Resumen: "Background: High phytoestrogen intake during adolescence is associated with a reduced risk of breast cancer. Breast density (BD) is a strong predictor of breast cancer and can be considered an early marker. We aim to assess the association between the mean habitual intake of isoflavones, lignans, and total phytoestrogens intake during puberty until 2 years after menarche onset and absolute fibroglandular volume (AFGV) and percentage of fibroglandular volume (%FGV) in Hispanic girls at the end of puberty.
Methods: Longitudinal study set up in the Growth and Obesity Chilean Cohort Study (GOCS). We included 329 girls with dietary data (multiple 24-hours recalls) from puberty until 2 years after menarche onset (81% had 2-4 recalls). Two international datasets were used to estimate isoflavones, lignans, and total phytoestrogens in the diet. Breast composition was measured by dual energy X-ray absorptiometry at 2 years after menarche. Multiple linear regression models were used to assess the association between isoflavones, lignans, and total phytoestrogens intake and AFGV and %FGV. Results: The average total phytoestrogen intake was 1 mg/day and %FGV was 50.7% (SD = 15.2) and AFGV 218.8 cm3 (SD = 79.3). An inverse association was found between consumption of isoflavones and AFGV, as well as, with total phytoestrogens [Q4 vs. Q1 adjusted model ß = -49.2 cm3; 95% CI (-85.5 to -13.0)].
Conclusions: Girls with a higher intake of total phytoestrogens and isoflavones during puberty until 2 years after menarche onset had significantly lower AFGV.
Impact: Although the intake of phytoestrogens is low in Western populations, higher consumption of them during a critical period of life like puberty could be beneficial to reduce breast cancer during adulthood."
Garmendia, María Luisa
Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study. Artículo de revista
En: BMC Cancer, 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_57,
title = {Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.},
author = {María Luisa Garmendia},
doi = {10.1186/s12885-022-09975-6},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {BMC Cancer},
abstract = {- Otros autores: Fontvieille E, His M, Biessy C, Navionis AS, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Navarro E, Rodas Cortes Y, Porras C, Rodriguez AC, Soto JL, Moyano L, Porter PL, Lin M, Guenthoer J, Romieu I, Rinaldi S & PRECAMA team.
- Cómo citar: Fontvieille E, His M, Biessy C, Navionis AS, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Navarro E, Rodas Cortes Y, Porras C, Rodriguez AC, Soto JL, Moyano L, Porter PL, Lin M, Guenthoer J, Romieu I, Rinaldi S & PRECAMA team. Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study. BMC Cancer. 2022;22, 877. doi: 10.1186/s12885-022-09975-6. PMID: 35948877 PMCID: PMC9367082. ISSN: 1471-2407. IF [JCR]: 4.638. Q2
- Resumen:"Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results: IL-6 (ORper standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (ORper SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only.
Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women."},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Fontvieille E, His M, Biessy C, Navionis AS, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Navarro E, Rodas Cortes Y, Porras C, Rodriguez AC, Soto JL, Moyano L, Porter PL, Lin M, Guenthoer J, Romieu I, Rinaldi S & PRECAMA team.
- Cómo citar: Fontvieille E, His M, Biessy C, Navionis AS, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Navarro E, Rodas Cortes Y, Porras C, Rodriguez AC, Soto JL, Moyano L, Porter PL, Lin M, Guenthoer J, Romieu I, Rinaldi S & PRECAMA team. Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study. BMC Cancer. 2022;22, 877. doi: 10.1186/s12885-022-09975-6. PMID: 35948877 PMCID: PMC9367082. ISSN: 1471-2407. IF [JCR]: 4.638. Q2
- Resumen:"Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results: IL-6 (ORper standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (ORper SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only.
Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women."
- Cómo citar: Fontvieille E, His M, Biessy C, Navionis AS, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Navarro E, Rodas Cortes Y, Porras C, Rodriguez AC, Soto JL, Moyano L, Porter PL, Lin M, Guenthoer J, Romieu I, Rinaldi S & PRECAMA team. Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study. BMC Cancer. 2022;22, 877. doi: 10.1186/s12885-022-09975-6. PMID: 35948877 PMCID: PMC9367082. ISSN: 1471-2407. IF [JCR]: 4.638. Q2
- Resumen:"Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results: IL-6 (ORper standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (ORper SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only.
Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women."
Corvalán, Camila; Pereira, Ana
Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls. Artículo de revista
En: Breast Cancer Res., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_71,
title = {Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls.},
author = {Camila Corvalán and Ana Pereira},
doi = {10.1186/s13058-021-01495-8},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Breast Cancer Res.},
abstract = {- Otros autores: Yoon L, Shepherd J, Michels KB.
- Cómo citar: Yoon L, Shepherd J, Michels KB. Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls. Breast Cancer Res. 2022;24(1):3. doi: 10.1186/s13058-021-01495-8. PMID: 34998441. PMCID: PMC8742361. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: "Background: Frequent sugar-sweetened beverage (SSB) intake has been associated with indirect markers of breast cancer risk, such as weight gain in adolescents and early menarche. How SSB intake relates to breast composition in adolescent girls has not been explored.
Methods: We evaluated the association between prospective intake of SSB and breast density in a cohort of 374 adolescent girls participating in the Growth and Obesity Cohort Study in Santiago, Chile. Multivariable linear regression models were used to analyze the association between average daily SSB intake quartiles and breast composition (absolute fibroglandular volume [aFGV], percent fibroglandular volume [%FGV], total breast volume [tBV]). Models were adjusted for potential confounding by BMI Z-score, age, daily energy intake (g/day), maternal education, hours of daily television watching after school, dairy intake (g/day), meat intake (g/day), waist circumference, and menarche. To examine the sensitivity of the association to the number of dietary recalls for each girl, analyses were further stratified by girls with one dietary recall and girls with > one dietary recall.
Results: A total of 881 dietary recalls were available for 374 girls prior to the breast density assessment. More than 60% of the cohort had > one dietary recall available. In multivariable analyses, we found no association between SSB intake quartile and aFGV (Q2 vs Q1 β: − 5.4, 95% CI − 15.1, 4.4; Q3 vs Q1 β: 1.3, 95% CI − 8.6, 11.3; Q4 vs Q1 β: 3.0, 95% CI − 7.1, 13). No associations were noted for %FGV and tBV. Among girls with at least one dietary recall, we found no significant associations between SSB intake quartiles and %FGV, aFGV, or tBV.
Conclusion: Overall, we observed no evidence that SSB intake was associated with breast density in adolescent Chilean girls."},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Yoon L, Shepherd J, Michels KB.
- Cómo citar: Yoon L, Shepherd J, Michels KB. Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls. Breast Cancer Res. 2022;24(1):3. doi: 10.1186/s13058-021-01495-8. PMID: 34998441. PMCID: PMC8742361. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: "Background: Frequent sugar-sweetened beverage (SSB) intake has been associated with indirect markers of breast cancer risk, such as weight gain in adolescents and early menarche. How SSB intake relates to breast composition in adolescent girls has not been explored.
Methods: We evaluated the association between prospective intake of SSB and breast density in a cohort of 374 adolescent girls participating in the Growth and Obesity Cohort Study in Santiago, Chile. Multivariable linear regression models were used to analyze the association between average daily SSB intake quartiles and breast composition (absolute fibroglandular volume [aFGV], percent fibroglandular volume [%FGV], total breast volume [tBV]). Models were adjusted for potential confounding by BMI Z-score, age, daily energy intake (g/day), maternal education, hours of daily television watching after school, dairy intake (g/day), meat intake (g/day), waist circumference, and menarche. To examine the sensitivity of the association to the number of dietary recalls for each girl, analyses were further stratified by girls with one dietary recall and girls with > one dietary recall.
Results: A total of 881 dietary recalls were available for 374 girls prior to the breast density assessment. More than 60% of the cohort had > one dietary recall available. In multivariable analyses, we found no association between SSB intake quartile and aFGV (Q2 vs Q1 β: − 5.4, 95% CI − 15.1, 4.4; Q3 vs Q1 β: 1.3, 95% CI − 8.6, 11.3; Q4 vs Q1 β: 3.0, 95% CI − 7.1, 13). No associations were noted for %FGV and tBV. Among girls with at least one dietary recall, we found no significant associations between SSB intake quartiles and %FGV, aFGV, or tBV.
Conclusion: Overall, we observed no evidence that SSB intake was associated with breast density in adolescent Chilean girls."
- Cómo citar: Yoon L, Shepherd J, Michels KB. Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls. Breast Cancer Res. 2022;24(1):3. doi: 10.1186/s13058-021-01495-8. PMID: 34998441. PMCID: PMC8742361. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: "Background: Frequent sugar-sweetened beverage (SSB) intake has been associated with indirect markers of breast cancer risk, such as weight gain in adolescents and early menarche. How SSB intake relates to breast composition in adolescent girls has not been explored.
Methods: We evaluated the association between prospective intake of SSB and breast density in a cohort of 374 adolescent girls participating in the Growth and Obesity Cohort Study in Santiago, Chile. Multivariable linear regression models were used to analyze the association between average daily SSB intake quartiles and breast composition (absolute fibroglandular volume [aFGV], percent fibroglandular volume [%FGV], total breast volume [tBV]). Models were adjusted for potential confounding by BMI Z-score, age, daily energy intake (g/day), maternal education, hours of daily television watching after school, dairy intake (g/day), meat intake (g/day), waist circumference, and menarche. To examine the sensitivity of the association to the number of dietary recalls for each girl, analyses were further stratified by girls with one dietary recall and girls with > one dietary recall.
Results: A total of 881 dietary recalls were available for 374 girls prior to the breast density assessment. More than 60% of the cohort had > one dietary recall available. In multivariable analyses, we found no association between SSB intake quartile and aFGV (Q2 vs Q1 β: − 5.4, 95% CI − 15.1, 4.4; Q3 vs Q1 β: 1.3, 95% CI − 8.6, 11.3; Q4 vs Q1 β: 3.0, 95% CI − 7.1, 13). No associations were noted for %FGV and tBV. Among girls with at least one dietary recall, we found no significant associations between SSB intake quartiles and %FGV, aFGV, or tBV.
Conclusion: Overall, we observed no evidence that SSB intake was associated with breast density in adolescent Chilean girls."
Pereira, Ana; Garmendia, María Luisa
The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Artículo de revista
En: Breast Cancer Res., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_61,
title = {The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.},
author = {Ana Pereira and María Luisa Garmendia},
doi = {10.1186/s13058-022-01545-9},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Breast Cancer Res.},
abstract = {- Otros autores: Ward SV, Burton A, Tamimi RM, Pollan M, Boyd N, Dos-Santos-Silva I, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Bertrand K, Kwong A, Ursin G, Lee E, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Peplonska B, Bukowska-Damska A, Nagata C, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Flugelman AA, Salem D, Kamal R, McCormack V, Stone J.
- Cómo citar: Ward SV, Burton A, Tamimi RM, Pollan M, Boyd N, Dos-Santos-Silva I, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Bertrand K, Kwong A, Ursin G, Lee E, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Peplonska B, Bukowska-Damska A, Nagata C, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Flugelman AA, Salem D, Kamal R, McCormack V, Stone J. The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Breast Cancer Res. 2022;24(1):49. doi: 10.1186/s13058-022-01545-9. PMID: 35836268. PMCID: PMC9284807. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
- Resumen: "Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.
Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Ward SV, Burton A, Tamimi RM, Pollan M, Boyd N, Dos-Santos-Silva I, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Bertrand K, Kwong A, Ursin G, Lee E, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Peplonska B, Bukowska-Damska A, Nagata C, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Flugelman AA, Salem D, Kamal R, McCormack V, Stone J.
- Cómo citar: Ward SV, Burton A, Tamimi RM, Pollan M, Boyd N, Dos-Santos-Silva I, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Bertrand K, Kwong A, Ursin G, Lee E, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Peplonska B, Bukowska-Damska A, Nagata C, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Flugelman AA, Salem D, Kamal R, McCormack V, Stone J. The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Breast Cancer Res. 2022;24(1):49. doi: 10.1186/s13058-022-01545-9. PMID: 35836268. PMCID: PMC9284807. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
- Resumen: "Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.
Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008
- Cómo citar: Ward SV, Burton A, Tamimi RM, Pollan M, Boyd N, Dos-Santos-Silva I, Maskarinec G, Perez-Gomez B, Vachon C, Miao H, Lajous M, López-Ridaura R, Bertrand K, Kwong A, Ursin G, Lee E, Ma H, Vinnicombe S, Moss S, Allen S, Ndumia R, Vinayak S, Teo SH, Mariapun S, Peplonska B, Bukowska-Damska A, Nagata C, Hopper J, Giles G, Ozmen V, Aribal ME, Schüz J, Van Gils CH, Wanders JOP, Sirous R, Sirous M, Hipwell J, Kim J, Lee JW, Dickens C, Hartman M, Chia KS, Scott C, Chiarelli AM, Linton L, Flugelman AA, Salem D, Kamal R, McCormack V, Stone J. The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Breast Cancer Res. 2022;24(1):49. doi: 10.1186/s13058-022-01545-9. PMID: 35836268. PMCID: PMC9284807. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
- Resumen: "Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.
Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008
Pereira, Ana; Corvalán, Camila
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls Artículo de revista
En: Environ. Int., 2022.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls},
author = {Ana Pereira and Camila Corvalán},
doi = {doi: 10.1016/j.envint.2022.107586},
year = {2022},
date = {2022-00-00},
urldate = {2022-00-00},
journal = {Environ. Int.},
abstract = {- Otros autores: Yoon L, Binder A, Calafat A, Shepherd J, Michels K.
- Cómo citar: Yoon L, Binder A, Pereira A, Calafat A, Shepherd J, Corvalán C, Michels K. Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls. Environ. Int. 2022;107586. doi: 10.1016/j.envint.2022.107586. PMID: 36302292. ISSN: 0160-4120. IF [JCR]: 13.352. Q1
- Resumen: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis.
Methods: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Yoon L, Binder A, Calafat A, Shepherd J, Michels K.
- Cómo citar: Yoon L, Binder A, Pereira A, Calafat A, Shepherd J, Corvalán C, Michels K. Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls. Environ. Int. 2022;107586. doi: 10.1016/j.envint.2022.107586. PMID: 36302292. ISSN: 0160-4120. IF [JCR]: 13.352. Q1
- Resumen: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis.
Methods: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education.
- Cómo citar: Yoon L, Binder A, Pereira A, Calafat A, Shepherd J, Corvalán C, Michels K. Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls. Environ. Int. 2022;107586. doi: 10.1016/j.envint.2022.107586. PMID: 36302292. ISSN: 0160-4120. IF [JCR]: 13.352. Q1
- Resumen: Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis.
Methods: In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education.
2021
Corvalán, Camila; Pereira, Ana
The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile. Artículo de revista
En: Front. Cell. Infect. Microbiol., 2021.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_78,
title = {The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile.},
author = {Camila Corvalán and Ana Pereira},
doi = {10.3389/fcimb.2021.794610},
year = {2021},
date = {2021-00-00},
urldate = {2021-00-00},
journal = {Front. Cell. Infect. Microbiol.},
abstract = {- Otros autores: Yoon LS, Jacobs JP, Hoehner J, Gana JC, Michels KB.
- Cómo citar: Yoon LS, Jacobs JP, Hoehner J, Gana JC, Michels KB. The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile. Front. Cell. Infect. Microbiol. 2021;11:794610. doi: 10.3389/fcimb.2021.794610. PMID: 34976871. PMCID: PMC8718921. ISSN: 2235-2988. IF [JCR]: 6.073. Q1
-Resumen: The gut microbiome has been linked to breast cancer via immune, inflammatory, and hormonal mechanisms. We examined the relation between adolescent breast density and gut microbial composition and function in a cohort of Chilean girls. This cross-sectional study included 218 female participants in the Growth and Obesity Cohort Study who were 2 years post-menarche. We measured absolute breast fibroglandular volume (aFGV) and derived percent FGV (%FGV) using dual energy X-ray absorptiometry. All participants provided a fecal sample. The gut microbiome was characterized using 16S ribosomal RNA sequencing of the V3-V4 hypervariable region. We examined alpha diversity and beta diversity across terciles of %FGV and aFGV. We used MaAsLin2 for multivariable general linear modeling to assess differential taxa and predicted metabolic pathway abundance (MetaCyc) between %FGV and aFGV terciles. All models were adjusted for potential confounding variables and corrected for multiple comparisons. The mean %FGV and aFGV was 49.5% and 217.0 cm3, respectively, among study participants. Similar median alpha diversity levels were found across %FGV and aFGV terciles when measured by the Shannon diversity index (%FGV T1: 4.0, T2: 3.9, T3: 4.1; aFGV T1: 4.0, T2: 4.0, T3: 4.1). %FGV was associated with differences in beta diversity (R2 = 0.012},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Yoon LS, Jacobs JP, Hoehner J, Gana JC, Michels KB.
- Cómo citar: Yoon LS, Jacobs JP, Hoehner J, Gana JC, Michels KB. The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile. Front. Cell. Infect. Microbiol. 2021;11:794610. doi: 10.3389/fcimb.2021.794610. PMID: 34976871. PMCID: PMC8718921. ISSN: 2235-2988. IF [JCR]: 6.073. Q1
-Resumen: The gut microbiome has been linked to breast cancer via immune, inflammatory, and hormonal mechanisms. We examined the relation between adolescent breast density and gut microbial composition and function in a cohort of Chilean girls. This cross-sectional study included 218 female participants in the Growth and Obesity Cohort Study who were 2 years post-menarche. We measured absolute breast fibroglandular volume (aFGV) and derived percent FGV (%FGV) using dual energy X-ray absorptiometry. All participants provided a fecal sample. The gut microbiome was characterized using 16S ribosomal RNA sequencing of the V3-V4 hypervariable region. We examined alpha diversity and beta diversity across terciles of %FGV and aFGV. We used MaAsLin2 for multivariable general linear modeling to assess differential taxa and predicted metabolic pathway abundance (MetaCyc) between %FGV and aFGV terciles. All models were adjusted for potential confounding variables and corrected for multiple comparisons. The mean %FGV and aFGV was 49.5% and 217.0 cm3, respectively, among study participants. Similar median alpha diversity levels were found across %FGV and aFGV terciles when measured by the Shannon diversity index (%FGV T1: 4.0, T2: 3.9, T3: 4.1; aFGV T1: 4.0, T2: 4.0, T3: 4.1). %FGV was associated with differences in beta diversity (R2 = 0.012
- Cómo citar: Yoon LS, Jacobs JP, Hoehner J, Gana JC, Michels KB. The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile. Front. Cell. Infect. Microbiol. 2021;11:794610. doi: 10.3389/fcimb.2021.794610. PMID: 34976871. PMCID: PMC8718921. ISSN: 2235-2988. IF [JCR]: 6.073. Q1
-Resumen: The gut microbiome has been linked to breast cancer via immune, inflammatory, and hormonal mechanisms. We examined the relation between adolescent breast density and gut microbial composition and function in a cohort of Chilean girls. This cross-sectional study included 218 female participants in the Growth and Obesity Cohort Study who were 2 years post-menarche. We measured absolute breast fibroglandular volume (aFGV) and derived percent FGV (%FGV) using dual energy X-ray absorptiometry. All participants provided a fecal sample. The gut microbiome was characterized using 16S ribosomal RNA sequencing of the V3-V4 hypervariable region. We examined alpha diversity and beta diversity across terciles of %FGV and aFGV. We used MaAsLin2 for multivariable general linear modeling to assess differential taxa and predicted metabolic pathway abundance (MetaCyc) between %FGV and aFGV terciles. All models were adjusted for potential confounding variables and corrected for multiple comparisons. The mean %FGV and aFGV was 49.5% and 217.0 cm3, respectively, among study participants. Similar median alpha diversity levels were found across %FGV and aFGV terciles when measured by the Shannon diversity index (%FGV T1: 4.0, T2: 3.9, T3: 4.1; aFGV T1: 4.0, T2: 4.0, T3: 4.1). %FGV was associated with differences in beta diversity (R2 = 0.012
2020
Garmendia, María Luisa
Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study. Artículo de revista
En: Sci Rep., 2020.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_100,
title = {Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study.},
author = {María Luisa Garmendia},
doi = {10.1038/s41598-020-59056-6},
year = {2020},
date = {2020-00-00},
urldate = {2020-00-00},
journal = {Sci Rep.},
abstract = {- Otros autores: His M, Biessy C, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Borrero M, Porras C, Rodríguez AC, Olivier M, Porter PL, Lin MG, Gunter MJ, Romieu I, Rinaldi S, PRECAMA team.
- Cómo citar: His M, Biessy C, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Borrero M, Porras C, Rodríguez AC, Olivier M, Porter PL, Lin MG, Gunter MJ, Romieu I, Rinaldi S, PRECAMA team. Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study. Sci Rep. 2020;10:1-12. doi: 10.1038/s41598-020-59056-6. PMCID: PMC7010745. PMID: 32042008. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
-Resumen: Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: His M, Biessy C, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Borrero M, Porras C, Rodríguez AC, Olivier M, Porter PL, Lin MG, Gunter MJ, Romieu I, Rinaldi S, PRECAMA team.
- Cómo citar: His M, Biessy C, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Borrero M, Porras C, Rodríguez AC, Olivier M, Porter PL, Lin MG, Gunter MJ, Romieu I, Rinaldi S, PRECAMA team. Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study. Sci Rep. 2020;10:1-12. doi: 10.1038/s41598-020-59056-6. PMCID: PMC7010745. PMID: 32042008. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
-Resumen: Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.
- Cómo citar: His M, Biessy C, Torres-Mejía G, Ángeles-Llerenas A, Alvarado-Cabrero I, Sánchez GI, Borrero M, Porras C, Rodríguez AC, Olivier M, Porter PL, Lin MG, Gunter MJ, Romieu I, Rinaldi S, PRECAMA team. Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study. Sci Rep. 2020;10:1-12. doi: 10.1038/s41598-020-59056-6. PMCID: PMC7010745. PMID: 32042008. ISSN: 2045-2322. IF [JCR]: 4.996. Q2
-Resumen: Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.
Corvalán, Camila; Pereira, Ana
Association between Indicators of Systemic Inflammation Biomarkers During Puberty with Breast Density and Onset of Menarche. Artículo de revista
En: Breast Cancer Res., 2020.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_98,
title = {Association between Indicators of Systemic Inflammation Biomarkers During Puberty with Breast Density and Onset of Menarche.},
author = {Camila Corvalán and Ana Pereira},
doi = {10.1186/s13058-020-01338-y},
year = {2020},
date = {2020-00-00},
urldate = {2020-00-00},
journal = {Breast Cancer Res.},
abstract = {- Otros autores: Michels K, Keller K, Kim C, Santos JL, Shepherd J, Binder A.
- Cómo citar: Michels K, Keller K, Kim C, Santos JL, Shepherd J, Binder A. Association between Indicators of Systemic Inflammation Biomarkers During Puberty with Breast Density and Onset of Menarche. Breast Cancer Res. 2020;22:1-14. doi: 10.1186/s13058-020-01338-y. PMCID: PMC7531086. PMID: 33004039. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: Background Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls. Methods We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multivariable linear models were used to examine the association between breast composition and each inflammatory marker, stratifying by Tanner stage at inflammatory marker measurement. Accelerated failure time models were used to evaluate the association between inflammatory markers concentrations at each Tanner stage and time to menarche. Results In age-adjusted linear regression models, a doubling of TNFR2 at Tanner 2 was associated with a 26% (95% CI 7-48%) increase in total breast volume at Tanner 4 and a 22% (95% CI 10-32%) decrease of fibroglandular volume at Tanner 4. In multivariable models further adjusted for body fatness and other covariates, these associations were attenuated to the null. The time to menarche was 3% (95% CI 1-5%) shorter among those in the highest quartile of IL-6 at Tanner 2 relative to those in the lowest quartile in fully adjusted models. Compared to those in the lowest quartile of CRP at Tanner 4, those in the highest quartile experienced 2% (95% CI 0-3%) longer time to menarche in multivariable models. Conclusions Systemic inflammation during puberty was not associated with breast volume or breast density at the conclusion of breast development among pubertal girls after adjusting for body fatness; however, these circulating inflammation biomarkers, specifically CRP and IL-6, may affect the timing of menarche onset.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: Michels K, Keller K, Kim C, Santos JL, Shepherd J, Binder A.
- Cómo citar: Michels K, Keller K, Kim C, Santos JL, Shepherd J, Binder A. Association between Indicators of Systemic Inflammation Biomarkers During Puberty with Breast Density and Onset of Menarche. Breast Cancer Res. 2020;22:1-14. doi: 10.1186/s13058-020-01338-y. PMCID: PMC7531086. PMID: 33004039. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: Background Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls. Methods We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multivariable linear models were used to examine the association between breast composition and each inflammatory marker, stratifying by Tanner stage at inflammatory marker measurement. Accelerated failure time models were used to evaluate the association between inflammatory markers concentrations at each Tanner stage and time to menarche. Results In age-adjusted linear regression models, a doubling of TNFR2 at Tanner 2 was associated with a 26% (95% CI 7-48%) increase in total breast volume at Tanner 4 and a 22% (95% CI 10-32%) decrease of fibroglandular volume at Tanner 4. In multivariable models further adjusted for body fatness and other covariates, these associations were attenuated to the null. The time to menarche was 3% (95% CI 1-5%) shorter among those in the highest quartile of IL-6 at Tanner 2 relative to those in the lowest quartile in fully adjusted models. Compared to those in the lowest quartile of CRP at Tanner 4, those in the highest quartile experienced 2% (95% CI 0-3%) longer time to menarche in multivariable models. Conclusions Systemic inflammation during puberty was not associated with breast volume or breast density at the conclusion of breast development among pubertal girls after adjusting for body fatness; however, these circulating inflammation biomarkers, specifically CRP and IL-6, may affect the timing of menarche onset.
- Cómo citar: Michels K, Keller K, Kim C, Santos JL, Shepherd J, Binder A. Association between Indicators of Systemic Inflammation Biomarkers During Puberty with Breast Density and Onset of Menarche. Breast Cancer Res. 2020;22:1-14. doi: 10.1186/s13058-020-01338-y. PMCID: PMC7531086. PMID: 33004039. ISSN: 1465-5411. IF [JCR]: 8.408. Q1
-Resumen: Background Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls. Methods We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multivariable linear models were used to examine the association between breast composition and each inflammatory marker, stratifying by Tanner stage at inflammatory marker measurement. Accelerated failure time models were used to evaluate the association between inflammatory markers concentrations at each Tanner stage and time to menarche. Results In age-adjusted linear regression models, a doubling of TNFR2 at Tanner 2 was associated with a 26% (95% CI 7-48%) increase in total breast volume at Tanner 4 and a 22% (95% CI 10-32%) decrease of fibroglandular volume at Tanner 4. In multivariable models further adjusted for body fatness and other covariates, these associations were attenuated to the null. The time to menarche was 3% (95% CI 1-5%) shorter among those in the highest quartile of IL-6 at Tanner 2 relative to those in the lowest quartile in fully adjusted models. Compared to those in the lowest quartile of CRP at Tanner 4, those in the highest quartile experienced 2% (95% CI 0-3%) longer time to menarche in multivariable models. Conclusions Systemic inflammation during puberty was not associated with breast volume or breast density at the conclusion of breast development among pubertal girls after adjusting for body fatness; however, these circulating inflammation biomarkers, specifically CRP and IL-6, may affect the timing of menarche onset.
Garmendia, María Luisa; Pereira, Ana; Corvalán, Camila
Effect of excessive gestational weight on daughters' breast density at the end of puberty onset. Artículo de revista
En: Sci Rep., 2020.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey_103,
title = {Effect of excessive gestational weight on daughters' breast density at the end of puberty onset.},
author = {María Luisa Garmendia and Ana Pereira and Camila Corvalán},
doi = {10.1038/s41598-020-63260-9},
year = {2020},
date = {2020-00-00},
urldate = {2020-00-00},
journal = {Sci Rep.},
abstract = {- Otros autores: López A, Shepherd J, Michels K.
- Cómo citar: López A, Shepherd J, Michels K. Effect of excessive gestational weight on daughters' breast density at the end of puberty onset. Sci Rep. 2020;10:6636. doi: 10.1038/s41598-020-63260-9. PMCID: PMC7171116. PMID: 32313106. ISSN: 2045-2322. IF [JCR]: 4.996. Q1
-Resumen: The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters’ breast density is unclear. We aimed to assess the association between EGWG and daughters’ breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002–2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.},
keywords = { L2: Cánceres Asociados a la Nutrición. / },
pubstate = {published},
tppubtype = {article}
}
- Otros autores: López A, Shepherd J, Michels K.
- Cómo citar: López A, Shepherd J, Michels K. Effect of excessive gestational weight on daughters' breast density at the end of puberty onset. Sci Rep. 2020;10:6636. doi: 10.1038/s41598-020-63260-9. PMCID: PMC7171116. PMID: 32313106. ISSN: 2045-2322. IF [JCR]: 4.996. Q1
-Resumen: The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters’ breast density is unclear. We aimed to assess the association between EGWG and daughters’ breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002–2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.
- Cómo citar: López A, Shepherd J, Michels K. Effect of excessive gestational weight on daughters' breast density at the end of puberty onset. Sci Rep. 2020;10:6636. doi: 10.1038/s41598-020-63260-9. PMCID: PMC7171116. PMID: 32313106. ISSN: 2045-2322. IF [JCR]: 4.996. Q1
-Resumen: The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters’ breast density is unclear. We aimed to assess the association between EGWG and daughters’ breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002–2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16–3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.