Publicaciones académicas

@article{nokey,

title = {Prevalence of fatty pancreas and its relation with anthropometric values on the growth and obesity Cohort study},

author = {Ana Pereira },

doi = { https://doi.org/10.1016/j.jped.2024.09.007},

year  = {2024},

date = {2024-12-23},

journal = { Jornal de pediatria},

abstract = {- Otros autores: Alberti, G., Cantillo, T., De Barbieri, F., García, C., Villarroel, L., & Gana, J. C. 



- Cómo citar:  Alberti, G., Cantillo, T., Pereira, A., De Barbieri, F., García, C., Villarroel, L., & Gana, J. C. (2024). Prevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study. Jornal de pediatria, S0021-7557(24)00145-1. Advance online publication. https://doi.org/10.1016/j.jped.2024.09.007



- Resumen: Nonalcoholic Fatty Pancreas Disease (NAFPD) is characterized by excessive lipid accumulation within the pancreas in the absence of alcohol intake, potentially leading to pancreatic dysfunction and metabolic complications, including type 2 diabetes mellitus, acute and chronic pancreatitis, and pancreatic carcinoma. The authors aim to estimate the prevalence of NAFPD and its association with anthropometric parameters in a cohort of Chilean adolescents.

},

keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia.    /},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study},

author = {Ana Pereira },

doi = {https://doi.org/10.1159/000542963},

year  = {2024},

date = {2024-12-13},

journal = {Hormone research in paediatrics},

abstract = {- Otros autores: Rodríguez, F., Ponce, D., Miranda, J. P., Santos, J. L., Cutler, G. B., Jr, Barnafi, E., Iñiguez, G., & Mericq, V. 



- Cómo citar:  Rodríguez, F., Ponce, D., Miranda, J. P., Santos, J. L., Cutler, G. B., Jr, Pereira, A., Barnafi, E., Iñiguez, G., & Mericq, V. (2024). Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study. Hormone research in paediatrics, 1–17. Advance online publication. https://doi.org/10.1159/000542963



- Resumen: Premature adrenarche in girls is defined biochemically by an increase in adrenal androgen (DHEAS) levels above the age-specific reference range before age 8 years. Recently, increased levels of 11-oxyandrogens have also been reported in girls with premature adrenarche. Epigenetic modifications, specifically CpG methylation, may affect gene expression and/or activity of steroidogenic enzymes during developmental changes in adrenal androgen secretion.},

keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia.    /},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population},

author = {Ana Pereira },

doi = {https://doi.org/10.1093/hmg/ddae098},

year  = {2024},

date = {2024-09-19},

journal = {Human molecular genetics},

abstract = {- Otros autores: Vicuña, L., Barrientos, E., Leiva-Yamaguchi, V., Alvares, D., Mericq, V.



- Cómo citar:  Vicuña, L., Barrientos, E., Leiva-Yamaguchi, V., Alvares, D., Mericq, V., Pereira, A., & Eyheramendy, S. (2024). Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population. Human molecular genetics, 33(19), 1660–1670. https://doi.org/10.1093/hmg/ddae098



- Resumen: Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type 2 diabetes, metabolic disorders, bone fractures, and psychopathologies. Thus, knowing the age at which puberty is attained is crucial as it can serve as a risk factor for future diseases. Pubertal development is divided into five stages of sexual maturation in boys and girls according to the standardized Tanner scale. We performed genome-wide association studies (GWAS) on the "Growth and Obesity Chilean Cohort Study" cohort composed of admixed children with mainly European and Native American ancestry. Using joint models that integrate time-to-event data with longitudinal trajectories of body mass index (BMI), we identified genetic variants associated with phenotypic transitions between pairs of Tanner stages. We identified $42$ novel significant associations, most of them in boys. The GWAS on Tanner $3rightarrow 4$ transition in boys captured an association peak around the growth-related genes LARS2 and LIMD1 genes, the former of which causes ovarian dysfunction when mutated. The associated variants are expression and splicing Quantitative Trait Loci regulating gene expression and alternative splicing in multiple tissues. Further, higher individual Native American genetic ancestry proportions predicted a significantly earlier puberty onset in boys but not in girls. Finally, the joint models identified a longitudinal BMI parameter significantly associated with several Tanner stages' transitions, confirming the association of BMI with pubertal timing.},

keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia.    /},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk},

author = {Ana Pereira},

doi = {https://doi.org/10.3390/nu16060785},

year  = {2024},

date = {2024-03-09},

urldate = {2024-03-09},

journal = {Nutrients, 2024},

abstract = {- Otros autores:  Gigliola Alberti, Mariana Faune, José L. Santos, Florencia De Barbieri, Cristián García, Fernando Becerra, Juan Cristóbal Gana.



- Cómo citar: Alberti, G., Faune, M., Santos, J. L., De Barbieri, F., García, C., Pereira, A., Becerra, F., & Gana, J. C. (2024). Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk. Nutrients, 16(6), 785. https://doi.org/10.3390/nu16060785



- Resumen: NAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and their association with the risk of developing nonalcoholic fatty liver disease (NAFLD) during adolescence. The participants were part of the 'Chilean Growth and Obesity Cohort Study', comprising 784 children who were followed prospectively from age 3 years. Annual assessments of nutritional status and body composition were conducted, with ultrasound screening for NAFLD during adolescence revealing a 9.8% prevalence. Higher waist circumference measures were associated with NAFLD from age 3 years (p = 0.03), all skin folds from age 4 years (p < 0.01), and DXA body fat measurements from age 12 years (p = 0.01). The fat-free mass index was higher in females (p = 0.006) but not in males (p = 0.211). The second and third tertiles of the fat mass index (FMI) had odds ratios for NAFLD during adolescence of 2.19 (1.48-3.25, 95% CI) and 6.94 (4.79-10.04, 95% CI), respectively. Elevated waist circumference, skin folds, and total body fat were identified as risk factors for future NAFLD development. A higher FMI during childhood was associated with an increased risk of NAFLD during adolescence.

Keywords: body composition; fat mass index; fat-free mass Index; liver steatosis.},

keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia.    /},

pubstate = {published},

tppubtype = {article}

}