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2024
Pereira, Ana
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development Artículo de revista
En: Biological research, 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development},
author = {Ana Pereira},
doi = {https://doi.org/10.1186/s40659-024-00574-2},
year = {2024},
date = {2024-12-18},
journal = {Biological research},
abstract = {- Otros autores: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I.
- Cómo citar: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Periera, A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I. (2024). A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development. Biological research, 57(1), 95. https://doi.org/10.1186/s40659-024-00574-2
- Resumen: Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Periera, A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I. (2024). A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development. Biological research, 57(1), 95. https://doi.org/10.1186/s40659-024-00574-2
- Resumen: Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy.
Garmendia, María Luisa
En: Social science & medicine, 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: a qualitative study with health professionals, managers and policymakers},
author = {María Luisa Garmendia },
doi = {https://doi.org/10.1016/j.socscimed.2024.117499},
year = {2024},
date = {2024-11-15},
journal = {Social science & medicine},
abstract = {- Otros autores: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project.
- Cómo citar: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project (2024). Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: A qualitative study with health professionals, managers and policymakers. Social science & medicine (1982), 365, 117499. Advance online publication. https://doi.org/10.1016/j.socscimed.2024.117499
- Resumen: Although the greatest delays in cancer diagnosis in Latin America occur in the provider interval little is known about the related factors. This study aims to analyze factors influencing access to cancer diagnosis -from initial contact with health services to confirmation- from institutional stakeholders' perspective in public healthcare networks of Chile, Colombia, and Ecuador. A qualitative, descriptive-interpretative study was conducted in two networks per country, using semi-structured individual interviews (n = 118; 23 to 58, per country) with a criterion sample of health professionals and administrative personnel from primary care (PC) (n = 41) and secondary/tertiary care hospitals (n = 47), network managers and policymakers (n = 30). The final sample size was reached through saturation. Thematic content analysis was performed, segmented by country. The analysis reveals interacting factors that cause cumulative delays throughout the patient's diagnostic pathway within healthcare networks, with differences between countries. In all three, informants identify similar characteristics of the networks: structural (deficits in diagnostic resources; geographical accessibility), organizational factors (long waiting times, especially after referral), and the limited knowledge and experience of PC doctors, which all lead to delayed diagnosis. In Chile and Colombia, health policy barriers related to care rationing/prioritization policies that hampered access to tests, and in Chile, increased delays for non-prioritized conditions. Country-specific barriers related to the organization of healthcare system also emerge: in Chile, private services subcontracting and the voucher system for using them; in Colombia, the management of care by insurers (care authorizations; fragmented and short-term contracting of providers); and in Ecuador, underfunding of the system. The barriers most affect the elderly, those with low socioeconomic status, with limited support networks, and rural areas residents. The results reveal relevant barriers in access to timely cancer diagnosis which can and should be addressed with specific cancer diagnosis policies and general measures that strengthen public healthcare systems and networks.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project (2024). Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: A qualitative study with health professionals, managers and policymakers. Social science & medicine (1982), 365, 117499. Advance online publication. https://doi.org/10.1016/j.socscimed.2024.117499
- Resumen: Although the greatest delays in cancer diagnosis in Latin America occur in the provider interval little is known about the related factors. This study aims to analyze factors influencing access to cancer diagnosis -from initial contact with health services to confirmation- from institutional stakeholders' perspective in public healthcare networks of Chile, Colombia, and Ecuador. A qualitative, descriptive-interpretative study was conducted in two networks per country, using semi-structured individual interviews (n = 118; 23 to 58, per country) with a criterion sample of health professionals and administrative personnel from primary care (PC) (n = 41) and secondary/tertiary care hospitals (n = 47), network managers and policymakers (n = 30). The final sample size was reached through saturation. Thematic content analysis was performed, segmented by country. The analysis reveals interacting factors that cause cumulative delays throughout the patient's diagnostic pathway within healthcare networks, with differences between countries. In all three, informants identify similar characteristics of the networks: structural (deficits in diagnostic resources; geographical accessibility), organizational factors (long waiting times, especially after referral), and the limited knowledge and experience of PC doctors, which all lead to delayed diagnosis. In Chile and Colombia, health policy barriers related to care rationing/prioritization policies that hampered access to tests, and in Chile, increased delays for non-prioritized conditions. Country-specific barriers related to the organization of healthcare system also emerge: in Chile, private services subcontracting and the voucher system for using them; in Colombia, the management of care by insurers (care authorizations; fragmented and short-term contracting of providers); and in Ecuador, underfunding of the system. The barriers most affect the elderly, those with low socioeconomic status, with limited support networks, and rural areas residents. The results reveal relevant barriers in access to timely cancer diagnosis which can and should be addressed with specific cancer diagnosis policies and general measures that strengthen public healthcare systems and networks.
Pereira, Ana; Garmendia, María Luisa
Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study Artículo de revista
En: Breast Cancer Res , 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study},
author = {Ana Pereira and María Luisa Garmendia },
doi = {doi: 10.1186/s13058-024-01890-x},
year = {2024},
date = {2024-09-30},
journal = {Breast Cancer Res },
abstract = {- Otros autores: Jessica O’Driscoll, Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, A. Heather Eliassen, Ana Pereira, Maria Luisa Garmendia, Rulla M. Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Samera A. Qureshi, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Farhana Fadzli, Beata Peplonska, Chisato Nagata, Jennifer Stone, John L. Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schüz, Carla H. Van Gils, Johanna O. P. Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Mikael Hartman, Jingmei Li, Christopher Scott, Anna M. Chiarelli, Linda Linton, Marina Pollan, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Norman Boyd, Isabel dos-Santos-Silva, Valerie McCormack & Maeve Mullooly
- Cómo citar: O’Driscoll, J., Burton, A., Maskarinec, G. et al. Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study. Breast Cancer Res 26, 139 (2024). https://doi.org/10.1186/s13058-024-01890-x
- Resumen: Elevated mammographic density (MD) for a woman’s age and body mass index (BMI) is an established breast cancer risk factor. The relationship of parity, age at first birth, and breastfeeding with MD is less clear. We examined the associations of these factors with MD within the International Consortium of Mammographic Density (ICMD).},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: O’Driscoll, J., Burton, A., Maskarinec, G. et al. Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study. Breast Cancer Res 26, 139 (2024). https://doi.org/10.1186/s13058-024-01890-x
- Resumen: Elevated mammographic density (MD) for a woman’s age and body mass index (BMI) is an established breast cancer risk factor. The relationship of parity, age at first birth, and breastfeeding with MD is less clear. We examined the associations of these factors with MD within the International Consortium of Mammographic Density (ICMD).
Pereira, Ana; Corvalán, Camila
Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile Artículo de revista
En: International journal of cancer, 155(4), 627–636., 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile},
author = {Ana Pereira and Camila Corvalán },
doi = {https://doi.org/10.1002/ijc.34930},
year = {2024},
date = {2024-08-14},
urldate = {2024-08-14},
journal = {International journal of cancer, 155(4), 627–636.},
abstract = {- Otros autores: Claire E Kim, Alexandra M Binder, Chitra Amarasiriwardena, John A Shepherd, Karin B Michels.
- Cómo citar: Kim, C. E., Pereira, A., Binder, A. M., Amarasiriwardena, C., Shepherd, J. A., Corvalan, C., & Michels, K. B. (2024). Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile. International journal of cancer, 155(4), 627–636. https://doi.org/10.1002/ijc.34930
- Resumen: Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm3 increase in absolute FGV (β: 13.69, 95% confidence interval [CI]: 2.81, 24.52), while a doubling of lead concentration resulted in a 7.76 cm3 decrease in absolute FGV (β: -7.76, 95%CI: -14.71, -0.73). At B4, a doubling of barium concentration was associated with a 10.06 cm3 increase (β: 10.06, 95% CI: 1.44, 18.60), copper concentration with a 12.29 cm3 increase (β: 12.29, 95% CI: 2.78, 21.56), lead concentration with a 9.86 cm3 increase (β: 9.86, 95% CI: 0.73, 18.98), antimony concentration with a 12.97 cm3 increase (β: 12.97, 95% CI: 1.98, 23.79) and vanadium concentration with a 13.14 cm3 increase in absolute FGV (β: 13.14, 95% CI: 2.73, 23.58). Trace metals may affect pubertal breast density at varying developmental stages with implications for increased susceptibility for breast cancer.
Keywords: breast cancer; breast density; puberty; trace metals.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Kim, C. E., Pereira, A., Binder, A. M., Amarasiriwardena, C., Shepherd, J. A., Corvalan, C., & Michels, K. B. (2024). Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile. International journal of cancer, 155(4), 627–636. https://doi.org/10.1002/ijc.34930
- Resumen: Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm3 increase in absolute FGV (β: 13.69, 95% confidence interval [CI]: 2.81, 24.52), while a doubling of lead concentration resulted in a 7.76 cm3 decrease in absolute FGV (β: -7.76, 95%CI: -14.71, -0.73). At B4, a doubling of barium concentration was associated with a 10.06 cm3 increase (β: 10.06, 95% CI: 1.44, 18.60), copper concentration with a 12.29 cm3 increase (β: 12.29, 95% CI: 2.78, 21.56), lead concentration with a 9.86 cm3 increase (β: 9.86, 95% CI: 0.73, 18.98), antimony concentration with a 12.97 cm3 increase (β: 12.97, 95% CI: 1.98, 23.79) and vanadium concentration with a 13.14 cm3 increase in absolute FGV (β: 13.14, 95% CI: 2.73, 23.58). Trace metals may affect pubertal breast density at varying developmental stages with implications for increased susceptibility for breast cancer.
Keywords: breast cancer; breast density; puberty; trace metals.
Garmendia, María Luisa
Socio-economic factors related to premature death from colorectal cancer in Santiago de Chile, 2014–2018: a cross-sectional study Artículo de revista
En: Public health, 231, 1–6., 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Socio-economic factors related to premature death from colorectal cancer in Santiago de Chile, 2014–2018: a cross-sectional study},
author = {María Luisa Garmendia},
doi = {doi.org/10.1016/j.puhe.2024.03.003},
year = {2024},
date = {2024-05-06},
journal = {Public health, 231, 1–6.},
abstract = {- Otros autores: C Guerrero-Nancuante, P Eguiguren, C Bass
- Cómo citar: Guerrero-Nancuante, C., Eguiguren, P., Bass, C., & Garmendia, M. L. (2024). Socio-economic factors related to premature death from colorectal cancer in Santiago de Chile, 2014-2018: a cross-sectional study. Public health, 231, 1–6. https://doi.org/10.1016/j.puhe.2024.03.003
- Resumen: Objectives: In Chile, colorectal cancer (CRC) is the fourth cause of death by cancer. Few studies have evaluated the role of contextual and individual socio-economic variables associated with premature death by CRC (<70 years). We analyzed the association between socio-economic factors (at individual and contextual levels) and premature death from CRC in Santiago de Chile. Study design: This was a cross-sectional study.},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Guerrero-Nancuante, C., Eguiguren, P., Bass, C., & Garmendia, M. L. (2024). Socio-economic factors related to premature death from colorectal cancer in Santiago de Chile, 2014-2018: a cross-sectional study. Public health, 231, 1–6. https://doi.org/10.1016/j.puhe.2024.03.003
- Resumen: Objectives: In Chile, colorectal cancer (CRC) is the fourth cause of death by cancer. Few studies have evaluated the role of contextual and individual socio-economic variables associated with premature death by CRC (<70 years). We analyzed the association between socio-economic factors (at individual and contextual levels) and premature death from CRC in Santiago de Chile. Study design: This was a cross-sectional study.
Pereira, Ana; Garmendia, María Luisa; Corvalán, Camila
Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study. Artículo de revista
En: 2024.
Resumen | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study.},
author = {Ana Pereira and María Luisa Garmendia and Camila Corvalán},
year = {2024},
date = {2024-03-12},
abstract = {- Otros autores: Valeria Leiva, Karin B Michels, John Shepherd.
- Cómo citar: Pereira, A., Garmendia, M. L., Leiva, V., Corvalán, C., Michels, K. B., & Shepherd, J. (2024). Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study. Breast cancer research : BCR, 26(1), 45. https://doi.org/10.1186/s13058-024-01793-x
- Resumen: Background: Breast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Understanding BD trajectories during puberty and its determinants could be crucial for promoting preventive actions against breast cancer (BC) at early ages. The objective of this research is to characterize % fibroglandular volume (%FGV), absolute fibroglandular volume (AFGV), and breast volume (BV) at different breast Tanner stages until 4-year post menarche in a Latino cohort and to assess determinants of high %FGV and AFGV during puberty and in a fully mature breast.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Pereira, A., Garmendia, M. L., Leiva, V., Corvalán, C., Michels, K. B., & Shepherd, J. (2024). Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study. Breast cancer research : BCR, 26(1), 45. https://doi.org/10.1186/s13058-024-01793-x
- Resumen: Background: Breast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Understanding BD trajectories during puberty and its determinants could be crucial for promoting preventive actions against breast cancer (BC) at early ages. The objective of this research is to characterize % fibroglandular volume (%FGV), absolute fibroglandular volume (AFGV), and breast volume (BV) at different breast Tanner stages until 4-year post menarche in a Latino cohort and to assess determinants of high %FGV and AFGV during puberty and in a fully mature breast.