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2024
Pereira, Ana
Prevalence of fatty pancreas and its relation with anthropometric values on the growth and obesity Cohort study Artículo de revista
En: Jornal de pediatria, 2024.
Resumen | Enlaces | Etiquetas: L3: Ventanas Críticas del Desarrollo: Adolescencia. /
@article{nokey,
title = {Prevalence of fatty pancreas and its relation with anthropometric values on the growth and obesity Cohort study},
author = {Ana Pereira },
doi = { https://doi.org/10.1016/j.jped.2024.09.007},
year = {2024},
date = {2024-12-23},
journal = { Jornal de pediatria},
abstract = {- Otros autores: Alberti, G., Cantillo, T., De Barbieri, F., García, C., Villarroel, L., & Gana, J. C.
- Cómo citar: Alberti, G., Cantillo, T., Pereira, A., De Barbieri, F., García, C., Villarroel, L., & Gana, J. C. (2024). Prevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study. Jornal de pediatria, S0021-7557(24)00145-1. Advance online publication. https://doi.org/10.1016/j.jped.2024.09.007
- Resumen: Nonalcoholic Fatty Pancreas Disease (NAFPD) is characterized by excessive lipid accumulation within the pancreas in the absence of alcohol intake, potentially leading to pancreatic dysfunction and metabolic complications, including type 2 diabetes mellitus, acute and chronic pancreatitis, and pancreatic carcinoma. The authors aim to estimate the prevalence of NAFPD and its association with anthropometric parameters in a cohort of Chilean adolescents.
},
keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Alberti, G., Cantillo, T., Pereira, A., De Barbieri, F., García, C., Villarroel, L., & Gana, J. C. (2024). Prevalence of Fatty Pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study. Jornal de pediatria, S0021-7557(24)00145-1. Advance online publication. https://doi.org/10.1016/j.jped.2024.09.007
- Resumen: Nonalcoholic Fatty Pancreas Disease (NAFPD) is characterized by excessive lipid accumulation within the pancreas in the absence of alcohol intake, potentially leading to pancreatic dysfunction and metabolic complications, including type 2 diabetes mellitus, acute and chronic pancreatitis, and pancreatic carcinoma. The authors aim to estimate the prevalence of NAFPD and its association with anthropometric parameters in a cohort of Chilean adolescents.
Pereira, Ana
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development Artículo de revista
En: Biological research, 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development},
author = {Ana Pereira},
doi = {https://doi.org/10.1186/s40659-024-00574-2},
year = {2024},
date = {2024-12-18},
journal = {Biological research},
abstract = {- Otros autores: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I.
- Cómo citar: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Periera, A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I. (2024). A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development. Biological research, 57(1), 95. https://doi.org/10.1186/s40659-024-00574-2
- Resumen: Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Periera, A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C., & Owen, G. I. (2024). A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development. Biological research, 57(1), 95. https://doi.org/10.1186/s40659-024-00574-2
- Resumen: Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare and research systems are unprepared for the social and economic burden of cancer. One decade ago, the authors put forward a comprehensive analysis of cancer infrastructure, together with a series of suggestions on research orientated political policy.
Pereira, Ana
Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study Artículo de revista
En: Hormone research in paediatrics, 2024.
Resumen | Enlaces | Etiquetas: L3: Ventanas Críticas del Desarrollo: Adolescencia. /
@article{nokey,
title = {Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study},
author = {Ana Pereira },
doi = {https://doi.org/10.1159/000542963},
year = {2024},
date = {2024-12-13},
journal = {Hormone research in paediatrics},
abstract = {- Otros autores: Rodríguez, F., Ponce, D., Miranda, J. P., Santos, J. L., Cutler, G. B., Jr, Barnafi, E., Iñiguez, G., & Mericq, V.
- Cómo citar: Rodríguez, F., Ponce, D., Miranda, J. P., Santos, J. L., Cutler, G. B., Jr, Pereira, A., Barnafi, E., Iñiguez, G., & Mericq, V. (2024). Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study. Hormone research in paediatrics, 1–17. Advance online publication. https://doi.org/10.1159/000542963
- Resumen: Premature adrenarche in girls is defined biochemically by an increase in adrenal androgen (DHEAS) levels above the age-specific reference range before age 8 years. Recently, increased levels of 11-oxyandrogens have also been reported in girls with premature adrenarche. Epigenetic modifications, specifically CpG methylation, may affect gene expression and/or activity of steroidogenic enzymes during developmental changes in adrenal androgen secretion.},
keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Rodríguez, F., Ponce, D., Miranda, J. P., Santos, J. L., Cutler, G. B., Jr, Pereira, A., Barnafi, E., Iñiguez, G., & Mericq, V. (2024). Differential Methylation of CYP11B1 in Girls with High DHEAS Levels and correlation with 11-Oxyandrogen levels: a pilot study. Hormone research in paediatrics, 1–17. Advance online publication. https://doi.org/10.1159/000542963
- Resumen: Premature adrenarche in girls is defined biochemically by an increase in adrenal androgen (DHEAS) levels above the age-specific reference range before age 8 years. Recently, increased levels of 11-oxyandrogens have also been reported in girls with premature adrenarche. Epigenetic modifications, specifically CpG methylation, may affect gene expression and/or activity of steroidogenic enzymes during developmental changes in adrenal androgen secretion.
Garmendia, María Luisa
En: Social science & medicine, 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: a qualitative study with health professionals, managers and policymakers},
author = {María Luisa Garmendia },
doi = {https://doi.org/10.1016/j.socscimed.2024.117499},
year = {2024},
date = {2024-11-15},
journal = {Social science & medicine},
abstract = {- Otros autores: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project.
- Cómo citar: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project (2024). Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: A qualitative study with health professionals, managers and policymakers. Social science & medicine (1982), 365, 117499. Advance online publication. https://doi.org/10.1016/j.socscimed.2024.117499
- Resumen: Although the greatest delays in cancer diagnosis in Latin America occur in the provider interval little is known about the related factors. This study aims to analyze factors influencing access to cancer diagnosis -from initial contact with health services to confirmation- from institutional stakeholders' perspective in public healthcare networks of Chile, Colombia, and Ecuador. A qualitative, descriptive-interpretative study was conducted in two networks per country, using semi-structured individual interviews (n = 118; 23 to 58, per country) with a criterion sample of health professionals and administrative personnel from primary care (PC) (n = 41) and secondary/tertiary care hospitals (n = 47), network managers and policymakers (n = 30). The final sample size was reached through saturation. Thematic content analysis was performed, segmented by country. The analysis reveals interacting factors that cause cumulative delays throughout the patient's diagnostic pathway within healthcare networks, with differences between countries. In all three, informants identify similar characteristics of the networks: structural (deficits in diagnostic resources; geographical accessibility), organizational factors (long waiting times, especially after referral), and the limited knowledge and experience of PC doctors, which all lead to delayed diagnosis. In Chile and Colombia, health policy barriers related to care rationing/prioritization policies that hampered access to tests, and in Chile, increased delays for non-prioritized conditions. Country-specific barriers related to the organization of healthcare system also emerge: in Chile, private services subcontracting and the voucher system for using them; in Colombia, the management of care by insurers (care authorizations; fragmented and short-term contracting of providers); and in Ecuador, underfunding of the system. The barriers most affect the elderly, those with low socioeconomic status, with limited support networks, and rural areas residents. The results reveal relevant barriers in access to timely cancer diagnosis which can and should be addressed with specific cancer diagnosis policies and general measures that strengthen public healthcare systems and networks.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Vargas, I., Mogollón-Pérez, A. S., Eguiguren, P., Torres, A. L., Peralta, A., Rubio-Valera, M., Jervelund, S. S., Borras, J. M., Dias, S., Vázquez, M. L., & EquityCancer-LA project (2024). Understanding the health system drivers of delayed cancer diagnosis in public healthcare networks of Chile, Colombia and Ecuador: A qualitative study with health professionals, managers and policymakers. Social science & medicine (1982), 365, 117499. Advance online publication. https://doi.org/10.1016/j.socscimed.2024.117499
- Resumen: Although the greatest delays in cancer diagnosis in Latin America occur in the provider interval little is known about the related factors. This study aims to analyze factors influencing access to cancer diagnosis -from initial contact with health services to confirmation- from institutional stakeholders' perspective in public healthcare networks of Chile, Colombia, and Ecuador. A qualitative, descriptive-interpretative study was conducted in two networks per country, using semi-structured individual interviews (n = 118; 23 to 58, per country) with a criterion sample of health professionals and administrative personnel from primary care (PC) (n = 41) and secondary/tertiary care hospitals (n = 47), network managers and policymakers (n = 30). The final sample size was reached through saturation. Thematic content analysis was performed, segmented by country. The analysis reveals interacting factors that cause cumulative delays throughout the patient's diagnostic pathway within healthcare networks, with differences between countries. In all three, informants identify similar characteristics of the networks: structural (deficits in diagnostic resources; geographical accessibility), organizational factors (long waiting times, especially after referral), and the limited knowledge and experience of PC doctors, which all lead to delayed diagnosis. In Chile and Colombia, health policy barriers related to care rationing/prioritization policies that hampered access to tests, and in Chile, increased delays for non-prioritized conditions. Country-specific barriers related to the organization of healthcare system also emerge: in Chile, private services subcontracting and the voucher system for using them; in Colombia, the management of care by insurers (care authorizations; fragmented and short-term contracting of providers); and in Ecuador, underfunding of the system. The barriers most affect the elderly, those with low socioeconomic status, with limited support networks, and rural areas residents. The results reveal relevant barriers in access to timely cancer diagnosis which can and should be addressed with specific cancer diagnosis policies and general measures that strengthen public healthcare systems and networks.
Reyes, Marcela; Pemjean, Isabel; Corvalán, Camila; Garmendia, María Luisa
Potential actions for preventing high consumption of Non-Nutritive Sweeteners among Chilean children and adolescents: recommendations from a panel of relevant actors Artículo de revista
En: Public Health Nutrition, 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {Potential actions for preventing high consumption of Non-Nutritive Sweeteners among Chilean children and adolescents: recommendations from a panel of relevant actors},
author = {Marcela Reyes and Isabel Pemjean and Camila Corvalán and María Luisa Garmendia},
doi = {doi:10.1017/S1368980024001745},
year = {2024},
date = {2024-10-08},
journal = { Public Health Nutrition},
abstract = {- Otros autores: Pino, C., Ortega, A.,
- Cómo citar: Reyes, M., Pino, C., Ortega, A., Pemjean, I., Corvalán, C., & Garmendia, M. L. (2024). Potential actions for preventing high consumption of Non-Nutritive Sweeteners among Chilean children and adolescents: recommendations from a panel of relevant actors. Public Health Nutrition, 27(1), e199. doi:10.1017/S1368980024001745
- Resumen: Objective:To provide local policymakers with a guideline of potential actions to prevent the high consumption of Non-Nutritive Sweeteners (NNS) among children and adolescents observed in Chile, given the potential health problems related to NNS intake.
},
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Reyes, M., Pino, C., Ortega, A., Pemjean, I., Corvalán, C., & Garmendia, M. L. (2024). Potential actions for preventing high consumption of Non-Nutritive Sweeteners among Chilean children and adolescents: recommendations from a panel of relevant actors. Public Health Nutrition, 27(1), e199. doi:10.1017/S1368980024001745
- Resumen: Objective:To provide local policymakers with a guideline of potential actions to prevent the high consumption of Non-Nutritive Sweeteners (NNS) among children and adolescents observed in Chile, given the potential health problems related to NNS intake.
Pereira, Ana; Garmendia, María Luisa
Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study Artículo de revista
En: Breast Cancer Res , 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study},
author = {Ana Pereira and María Luisa Garmendia },
doi = {doi: 10.1186/s13058-024-01890-x},
year = {2024},
date = {2024-09-30},
journal = {Breast Cancer Res },
abstract = {- Otros autores: Jessica O’Driscoll, Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martín Lajous, Ruy López-Ridaura, A. Heather Eliassen, Ana Pereira, Maria Luisa Garmendia, Rulla M. Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Samera A. Qureshi, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Farhana Fadzli, Beata Peplonska, Chisato Nagata, Jennifer Stone, John L. Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schüz, Carla H. Van Gils, Johanna O. P. Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Mikael Hartman, Jingmei Li, Christopher Scott, Anna M. Chiarelli, Linda Linton, Marina Pollan, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Norman Boyd, Isabel dos-Santos-Silva, Valerie McCormack & Maeve Mullooly
- Cómo citar: O’Driscoll, J., Burton, A., Maskarinec, G. et al. Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study. Breast Cancer Res 26, 139 (2024). https://doi.org/10.1186/s13058-024-01890-x
- Resumen: Elevated mammographic density (MD) for a woman’s age and body mass index (BMI) is an established breast cancer risk factor. The relationship of parity, age at first birth, and breastfeeding with MD is less clear. We examined the associations of these factors with MD within the International Consortium of Mammographic Density (ICMD).},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: O’Driscoll, J., Burton, A., Maskarinec, G. et al. Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study. Breast Cancer Res 26, 139 (2024). https://doi.org/10.1186/s13058-024-01890-x
- Resumen: Elevated mammographic density (MD) for a woman’s age and body mass index (BMI) is an established breast cancer risk factor. The relationship of parity, age at first birth, and breastfeeding with MD is less clear. We examined the associations of these factors with MD within the International Consortium of Mammographic Density (ICMD).
Rebolledo, Natalia; Reyes, Marcela; Corvalán, Camila
Decreases in purchases of energy, sodium, sugar, and saturated fat 3 years after implementation of the Chilean food labeling and marketing law: An interrupted time series analysis Artículo de revista
En: PloS, 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {Decreases in purchases of energy, sodium, sugar, and saturated fat 3 years after implementation of the Chilean food labeling and marketing law: An interrupted time series analysis},
author = {Natalia Rebolledo and Marcela Reyes and Camila Corvalán },
doi = {doi: 10.1371/journal.pmed.1004463},
year = {2024},
date = {2024-09-27},
journal = {PloS},
abstract = {- Otros autores: Smith Taillie L, Bercholz M, Popkin B.
- Cómo citar: Smith Taillie L, Bercholz M, Popkin B, Rebolledo N, Reyes M, Corvalán C. Decreases in purchases of energy, sodium, sugar, and saturated fat 3 years after implementation of the Chilean food labeling and marketing law: An interrupted time series analysis. PLoS Med. 2024;21(9):e1004463 doi: 10.1371/journal.pmed.1004463 PMID: 39331649 ISSN: 1549-1277. IF [JCR]: 10.5. Q1
- Resumen: In 2016, Chile implemented a multiphase set of policies that mandated warning labels, restricted food marketing to children, and banned school sales of foods and beverages high in nutrients of concern (“high-in” foods). Chile’s law, particularly the warning label component, set the precedent for a rapid global proliferation of similar policies. While our initial evaluation showed policy-linked decreases in purchases of high-in, a longer-term evaluation is needed, particularly as later phases of Chile’s law included stricter nutrient thresholds and introduced a daytime ban on advertising of high-in foods for all audiences. The objective is to evaluate changes in purchases of energy, sugar, sodium, and saturated fat purchased after Phase 2 implementation of the Chilean policies.},
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Smith Taillie L, Bercholz M, Popkin B, Rebolledo N, Reyes M, Corvalán C. Decreases in purchases of energy, sodium, sugar, and saturated fat 3 years after implementation of the Chilean food labeling and marketing law: An interrupted time series analysis. PLoS Med. 2024;21(9):e1004463 doi: 10.1371/journal.pmed.1004463 PMID: 39331649 ISSN: 1549-1277. IF [JCR]: 10.5. Q1
- Resumen: In 2016, Chile implemented a multiphase set of policies that mandated warning labels, restricted food marketing to children, and banned school sales of foods and beverages high in nutrients of concern (“high-in” foods). Chile’s law, particularly the warning label component, set the precedent for a rapid global proliferation of similar policies. While our initial evaluation showed policy-linked decreases in purchases of high-in, a longer-term evaluation is needed, particularly as later phases of Chile’s law included stricter nutrient thresholds and introduced a daytime ban on advertising of high-in foods for all audiences. The objective is to evaluate changes in purchases of energy, sugar, sodium, and saturated fat purchased after Phase 2 implementation of the Chilean policies.
Rebolledo, Natalia; Ferrer, Pedro; Reyes, Marcela; Corvalán, Camila
Food Industry Compliance With the Display of Front-of-Package Warning Labels at the Final Phase (2020) of Chile's Labeling and Advertising Law Artículo de revista
En: American Journal of Public Health , 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {Food Industry Compliance With the Display of Front-of-Package Warning Labels at the Final Phase (2020) of Chile's Labeling and Advertising Law},
author = {Natalia Rebolledo and Pedro Ferrer and Marcela Reyes and Camila Corvalán },
doi = {doi: 10.2105/AJPH.2024.307843},
year = {2024},
date = {2024-09-26},
journal = {American Journal of Public Health },
abstract = {- Otros autores: Taillie, L. S.
- Cómo citar: Rebolledo, N., Ferrer-Rosende, P., Reyes, M., Taillie, L. S., & Corvalán, C. (2024). Food Industry Compliance With the Display of Front-of-Package Warning Labels at the Final Phase (2020) of Chile's Labeling and Advertising Law. American journal of public health, 114(12), 1398–1405. https://doi.org/10.2105/AJPH.2024.307843
- Resumen: Objectives. To investigate food industry compliance with the display of front-of-package warning labels (FOPLs) on products that exceed regulatory thresholds for being high in calories, added sugars, sodium, or saturated fats after full implementation of Chile's Food Labeling and Advertising Law. Methods. In 2020, trained dietitians took pictures of nutritional information and FOPLs on packaged products in supermarkets. We categorized foods and beverages as requiring FOPLs (or not) using their nutritional composition and ingredients as set out in government guidelines. We compared these classifications with the actual display of FOPLs. },
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Rebolledo, N., Ferrer-Rosende, P., Reyes, M., Taillie, L. S., & Corvalán, C. (2024). Food Industry Compliance With the Display of Front-of-Package Warning Labels at the Final Phase (2020) of Chile's Labeling and Advertising Law. American journal of public health, 114(12), 1398–1405. https://doi.org/10.2105/AJPH.2024.307843
- Resumen: Objectives. To investigate food industry compliance with the display of front-of-package warning labels (FOPLs) on products that exceed regulatory thresholds for being high in calories, added sugars, sodium, or saturated fats after full implementation of Chile's Food Labeling and Advertising Law. Methods. In 2020, trained dietitians took pictures of nutritional information and FOPLs on packaged products in supermarkets. We categorized foods and beverages as requiring FOPLs (or not) using their nutritional composition and ingredients as set out in government guidelines. We compared these classifications with the actual display of FOPLs.
Pereira, Ana
Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population Artículo de revista
En: Human molecular genetics, 2024.
Resumen | Enlaces | Etiquetas: L3: Ventanas Críticas del Desarrollo: Adolescencia. /
@article{nokey,
title = {Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population},
author = {Ana Pereira },
doi = {https://doi.org/10.1093/hmg/ddae098},
year = {2024},
date = {2024-09-19},
journal = {Human molecular genetics},
abstract = {- Otros autores: Vicuña, L., Barrientos, E., Leiva-Yamaguchi, V., Alvares, D., Mericq, V.
- Cómo citar: Vicuña, L., Barrientos, E., Leiva-Yamaguchi, V., Alvares, D., Mericq, V., Pereira, A., & Eyheramendy, S. (2024). Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population. Human molecular genetics, 33(19), 1660–1670. https://doi.org/10.1093/hmg/ddae098
- Resumen: Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type 2 diabetes, metabolic disorders, bone fractures, and psychopathologies. Thus, knowing the age at which puberty is attained is crucial as it can serve as a risk factor for future diseases. Pubertal development is divided into five stages of sexual maturation in boys and girls according to the standardized Tanner scale. We performed genome-wide association studies (GWAS) on the "Growth and Obesity Chilean Cohort Study" cohort composed of admixed children with mainly European and Native American ancestry. Using joint models that integrate time-to-event data with longitudinal trajectories of body mass index (BMI), we identified genetic variants associated with phenotypic transitions between pairs of Tanner stages. We identified $42$ novel significant associations, most of them in boys. The GWAS on Tanner $3rightarrow 4$ transition in boys captured an association peak around the growth-related genes LARS2 and LIMD1 genes, the former of which causes ovarian dysfunction when mutated. The associated variants are expression and splicing Quantitative Trait Loci regulating gene expression and alternative splicing in multiple tissues. Further, higher individual Native American genetic ancestry proportions predicted a significantly earlier puberty onset in boys but not in girls. Finally, the joint models identified a longitudinal BMI parameter significantly associated with several Tanner stages' transitions, confirming the association of BMI with pubertal timing.},
keywords = {L3: Ventanas Críticas del Desarrollo: Adolescencia. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Vicuña, L., Barrientos, E., Leiva-Yamaguchi, V., Alvares, D., Mericq, V., Pereira, A., & Eyheramendy, S. (2024). Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population. Human molecular genetics, 33(19), 1660–1670. https://doi.org/10.1093/hmg/ddae098
- Resumen: Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type 2 diabetes, metabolic disorders, bone fractures, and psychopathologies. Thus, knowing the age at which puberty is attained is crucial as it can serve as a risk factor for future diseases. Pubertal development is divided into five stages of sexual maturation in boys and girls according to the standardized Tanner scale. We performed genome-wide association studies (GWAS) on the "Growth and Obesity Chilean Cohort Study" cohort composed of admixed children with mainly European and Native American ancestry. Using joint models that integrate time-to-event data with longitudinal trajectories of body mass index (BMI), we identified genetic variants associated with phenotypic transitions between pairs of Tanner stages. We identified $42$ novel significant associations, most of them in boys. The GWAS on Tanner $3rightarrow 4$ transition in boys captured an association peak around the growth-related genes LARS2 and LIMD1 genes, the former of which causes ovarian dysfunction when mutated. The associated variants are expression and splicing Quantitative Trait Loci regulating gene expression and alternative splicing in multiple tissues. Further, higher individual Native American genetic ancestry proportions predicted a significantly earlier puberty onset in boys but not in girls. Finally, the joint models identified a longitudinal BMI parameter significantly associated with several Tanner stages' transitions, confirming the association of BMI with pubertal timing.
Campos, Paola; Rebolledo, Natalia; Reyes, Marcela; Garmendia, María Luisa
Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort Artículo de revista
En: Nutrition , 2024.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort},
author = {Paola Campos and Natalia Rebolledo and Marcela Reyes and María Luisa Garmendia },
doi = {https://doi.org/10.1016/j.nut.2024.112560},
year = {2024},
date = {2024-09-18},
urldate = {2024-09-18},
journal = {Nutrition },
abstract = {- Otros autores: Campos, P., Durán, S., Flores, M.
- Cómo citar: Campos, P., Rebolledo, N., Durán, S., Flores, M., Reyes, M., & Garmendia, M. L. (2024). Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort. Nutrition (Burbank, Los Angeles County, Calif.), 128, 112560. Advance online publication. https://doi.org/10.1016/j.nut.2024.112560.
- Resumen: To evaluate the association between consumed non-nutritive sweeteners (NNS) and gestational diabetes mellitus (GDM) in a cohort of pregnant women from Santiago, Chile.},
keywords = {L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Campos, P., Rebolledo, N., Durán, S., Flores, M., Reyes, M., & Garmendia, M. L. (2024). Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort. Nutrition (Burbank, Los Angeles County, Calif.), 128, 112560. Advance online publication. https://doi.org/10.1016/j.nut.2024.112560.
- Resumen: To evaluate the association between consumed non-nutritive sweeteners (NNS) and gestational diabetes mellitus (GDM) in a cohort of pregnant women from Santiago, Chile.
Corvalán, Camila
Effectiveness of alcohol warning labels for at-risk groups and the general public: A policy-informing randomized experiment in Chile Artículo de revista
En: Preventive medicine, 187, 108087., 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {Effectiveness of alcohol warning labels for at-risk groups and the general public: A policy-informing randomized experiment in Chile},
author = {Camila Corvalán},
doi = {https://doi.org/10.1016/j.ypmed.2024.108087},
year = {2024},
date = {2024-09-02},
urldate = {2024-09-02},
journal = {Preventive medicine, 187, 108087.},
abstract = {- Otros autores: Daniel Schwartz, Ignacio Torres-Ulloa.
- Cómo citar: Schwartz, D., Torres-Ulloa, I., & Corvalán, C. (2024). Effectiveness of alcohol warning labels for at-risk groups and the general public: A policy-informing randomized experiment in Chile. Preventive medicine, 187, 108087. https://doi.org/10.1016/j.ypmed.2024.108087
- Resumen: Objective: The World Health Organization recommends using health-risk warnings on alcoholic beverages. This study examines the impact of separate or combined warning labels for at-risk groups and the general population on alcohol purchase decisions.
Methods: In 2022, 7758 adults who consumed alcohol or were pregnant/lactating women (54.0 % female, mean age = 40.6 years) were presented with an online store's beverage section and randomly assigned to one of six warning labels in a between-subjects experimental design: no-warning, pregnant/lactating, drinking-driving, general cancer risk, combined warnings, and assorted warnings across bottles. The main outcome, the intention to purchase an alcoholic vs. non-alcoholic beverage, was examined with adjusted risk differences using logistic regressions.},
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Schwartz, D., Torres-Ulloa, I., & Corvalán, C. (2024). Effectiveness of alcohol warning labels for at-risk groups and the general public: A policy-informing randomized experiment in Chile. Preventive medicine, 187, 108087. https://doi.org/10.1016/j.ypmed.2024.108087
- Resumen: Objective: The World Health Organization recommends using health-risk warnings on alcoholic beverages. This study examines the impact of separate or combined warning labels for at-risk groups and the general population on alcohol purchase decisions.
Methods: In 2022, 7758 adults who consumed alcohol or were pregnant/lactating women (54.0 % female, mean age = 40.6 years) were presented with an online store's beverage section and randomly assigned to one of six warning labels in a between-subjects experimental design: no-warning, pregnant/lactating, drinking-driving, general cancer risk, combined warnings, and assorted warnings across bottles. The main outcome, the intention to purchase an alcoholic vs. non-alcoholic beverage, was examined with adjusted risk differences using logistic regressions.
Zancheta, Camila; Rebolledo, Natalia; Reyes, Marcela; Corvalán, Camila
The consumption of ultra-processed foods was associated with adiposity, but not with metabolic indicators in a prospective cohort study of Chilean preschool children Artículo de revista
En: BMC Med 22, 340 (2024)., 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {The consumption of ultra-processed foods was associated with adiposity, but not with metabolic indicators in a prospective cohort study of Chilean preschool children},
author = {Camila Zancheta and Natalia Rebolledo and Marcela Reyes and Camila Corvalán},
doi = {https://doi.org/10.1186/s12916-024-03556-z},
year = {2024},
date = {2024-08-24},
journal = {BMC Med 22, 340 (2024).},
abstract = {- Otros autores: Lindsey Smith Taillie.
- Cómo citar: Zancheta, C., Rebolledo, N., Smith Taillie, L. et al. The consumption of ultra-processed foods was associated with adiposity, but not with metabolic indicators in a prospective cohort study of Chilean preschool children. BMC Med 22, 340 (2024). https://doi.org/10.1186/s12916-024-03556-z
- Resumen: Increasing consumption of ultra-processed foods (UPF) has been identified as a risk factor for obesity and various diseases, primarily in adults. Nonetheless, research in children is limited, especially regarding longitudinal studies with metabolic outcomes. We aimed to evaluate the longitudinal association between consumption of UPF, adiposity, and metabolic indicators in Chilean preschool children.},
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Zancheta, C., Rebolledo, N., Smith Taillie, L. et al. The consumption of ultra-processed foods was associated with adiposity, but not with metabolic indicators in a prospective cohort study of Chilean preschool children. BMC Med 22, 340 (2024). https://doi.org/10.1186/s12916-024-03556-z
- Resumen: Increasing consumption of ultra-processed foods (UPF) has been identified as a risk factor for obesity and various diseases, primarily in adults. Nonetheless, research in children is limited, especially regarding longitudinal studies with metabolic outcomes. We aimed to evaluate the longitudinal association between consumption of UPF, adiposity, and metabolic indicators in Chilean preschool children.
Pereira, Ana; Corvalán, Camila
Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile Artículo de revista
En: International journal of cancer, 155(4), 627–636., 2024.
Resumen | Enlaces | Etiquetas: L2: Cánceres Asociados a la Nutrición. /
@article{nokey,
title = {Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile},
author = {Ana Pereira and Camila Corvalán },
doi = {https://doi.org/10.1002/ijc.34930},
year = {2024},
date = {2024-08-14},
urldate = {2024-08-14},
journal = {International journal of cancer, 155(4), 627–636.},
abstract = {- Otros autores: Claire E Kim, Alexandra M Binder, Chitra Amarasiriwardena, John A Shepherd, Karin B Michels.
- Cómo citar: Kim, C. E., Pereira, A., Binder, A. M., Amarasiriwardena, C., Shepherd, J. A., Corvalan, C., & Michels, K. B. (2024). Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile. International journal of cancer, 155(4), 627–636. https://doi.org/10.1002/ijc.34930
- Resumen: Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm3 increase in absolute FGV (β: 13.69, 95% confidence interval [CI]: 2.81, 24.52), while a doubling of lead concentration resulted in a 7.76 cm3 decrease in absolute FGV (β: -7.76, 95%CI: -14.71, -0.73). At B4, a doubling of barium concentration was associated with a 10.06 cm3 increase (β: 10.06, 95% CI: 1.44, 18.60), copper concentration with a 12.29 cm3 increase (β: 12.29, 95% CI: 2.78, 21.56), lead concentration with a 9.86 cm3 increase (β: 9.86, 95% CI: 0.73, 18.98), antimony concentration with a 12.97 cm3 increase (β: 12.97, 95% CI: 1.98, 23.79) and vanadium concentration with a 13.14 cm3 increase in absolute FGV (β: 13.14, 95% CI: 2.73, 23.58). Trace metals may affect pubertal breast density at varying developmental stages with implications for increased susceptibility for breast cancer.
Keywords: breast cancer; breast density; puberty; trace metals.
},
keywords = {L2: Cánceres Asociados a la Nutrición. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Kim, C. E., Pereira, A., Binder, A. M., Amarasiriwardena, C., Shepherd, J. A., Corvalan, C., & Michels, K. B. (2024). Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile. International journal of cancer, 155(4), 627–636. https://doi.org/10.1002/ijc.34930
- Resumen: Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post-menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual-energy x-ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm3 increase in absolute FGV (β: 13.69, 95% confidence interval [CI]: 2.81, 24.52), while a doubling of lead concentration resulted in a 7.76 cm3 decrease in absolute FGV (β: -7.76, 95%CI: -14.71, -0.73). At B4, a doubling of barium concentration was associated with a 10.06 cm3 increase (β: 10.06, 95% CI: 1.44, 18.60), copper concentration with a 12.29 cm3 increase (β: 12.29, 95% CI: 2.78, 21.56), lead concentration with a 9.86 cm3 increase (β: 9.86, 95% CI: 0.73, 18.98), antimony concentration with a 12.97 cm3 increase (β: 12.97, 95% CI: 1.98, 23.79) and vanadium concentration with a 13.14 cm3 increase in absolute FGV (β: 13.14, 95% CI: 2.73, 23.58). Trace metals may affect pubertal breast density at varying developmental stages with implications for increased susceptibility for breast cancer.
Keywords: breast cancer; breast density; puberty; trace metals.
Ferrer, Pedro; Garmendia, María Luisa
Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy Artículo de revista
En: Journal of pediatric gastroenterology and nutrition, 79(2), 371–381, 2024.
Resumen | Enlaces | Etiquetas: L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /
@article{nokey,
title = {Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy},
author = {Pedro Ferrer and María Luisa Garmendia},
doi = {https://doi.org/10.1002/jpn3.12294},
year = {2024},
date = {2024-08-05},
journal = {Journal of pediatric gastroenterology and nutrition, 79(2), 371–381},
abstract = {- Otros autores: Valeria De Toro, Gigliola Alberti, Angelica Dominguez, Karina Carrasco-Negüe, Rodrigo Valenzuela, Paola Casanello.
- Cómo citar: De Toro, V., Alberti, G., Dominguez, A., Carrasco-Negüe, K., Ferrer, P., Valenzuela, R., Garmendia, M. L., & Casanello, P. (2024). Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy. Journal of pediatric gastroenterology and nutrition, 79(2), 371–381. https://doi.org/10.1002/jpn3.12294
- Resumen: Background: Previous studies of maternal docosahexaenoic acid (DHA) supplementation during pregnancy have controversial and contrasting results on the short and long-term effects on early child growth. The impact of this nutritional intervention on the postnatal growth patterns in the offspring of women with pregestational overweight/obesity (PGO) also remains controversial.
Objective: To analyze the postnatal growth patterns during the first 4 months of life in the offspring of women with PGO randomly supplemented with 800 mg/day (PGO-800) compared with normative doses of 200 mg/day (PGO-200) of DHA during pregnancy (<15 weeks of gestation until delivery).},
keywords = {L4: Ventanas Críticas del Desarrollo: Materno-Infantil. /},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: De Toro, V., Alberti, G., Dominguez, A., Carrasco-Negüe, K., Ferrer, P., Valenzuela, R., Garmendia, M. L., & Casanello, P. (2024). Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy. Journal of pediatric gastroenterology and nutrition, 79(2), 371–381. https://doi.org/10.1002/jpn3.12294
- Resumen: Background: Previous studies of maternal docosahexaenoic acid (DHA) supplementation during pregnancy have controversial and contrasting results on the short and long-term effects on early child growth. The impact of this nutritional intervention on the postnatal growth patterns in the offspring of women with pregestational overweight/obesity (PGO) also remains controversial.
Objective: To analyze the postnatal growth patterns during the first 4 months of life in the offspring of women with PGO randomly supplemented with 800 mg/day (PGO-800) compared with normative doses of 200 mg/day (PGO-200) of DHA during pregnancy (<15 weeks of gestation until delivery).
Corvalán, Camila
Chilean children’s adherence to sustainable healthy diets and its associations with sociodemographic and anthropometric factors: a cross-sectional study Artículo de revista
En: Eur J Nutr (2024), 2024.
Resumen | Enlaces | Etiquetas: Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta
@article{nokey,
title = {Chilean children’s adherence to sustainable healthy diets and its associations with sociodemographic and anthropometric factors: a cross-sectional study},
author = {Camila Corvalán},
doi = {10.1007/s00394-024-03435-6},
year = {2024},
date = {2024-06-10},
journal = {Eur J Nutr (2024)},
abstract = {- Otros autores: Venegas Hargous, Carolina & Orellana, Liliana & Strugnell, Claudia & Allender, Steven & Bell, Andrew.
- Cómo citar: Venegas Hargous, Carolina & Orellana, Liliana & Corvalán, Camila & Strugnell, Claudia & Allender, Steven & Bell, Andrew. (2024). Chilean children’s adherence to sustainable healthy diets and its associations with sociodemographic and anthropometric factors: a cross-sectional study. European Journal of Nutrition. 10.1007/s00394-024-03435-6.
- Resumen: To describe adherence to sustainable healthy diets among a sample of 958 Chilean pre-schoolers (3–6 years) and explore associations between adherence and child and maternal sociodemographic and anthropometric characteristics.
Methods
Children’s adherence to sustainable healthy diets was calculated from single multiple-pass 24-h dietary recalls using the Planetary Health Diet Index for children and adolescents (PHDI-C). Higher PHDI-C scores (max score = 150 points) represent greater adherence. Adjusted linear regression models were fitted to explore associations between PHDI-C scores and child and maternal characteristics.
Results
Children obtained low total PHDI-C scores (median 50.0 [IQR 39.5–59.8] points). This resulted from low consumption of nuts & peanuts, legumes, vegetables, whole cereals, and vegetable oils; a lack of balance between dark green and red & orange vegetables, inadequate consumption of tubers & potatoes and eggs & white meats, and excess consumption of dairy products, palm oil, red meats, and added sugars. Mean PHDI-C total score was significantly higher (50.6 [95%CI 49.6, 51.7] vs 47.3 [95%CI 45.0, 49.5]) among children whose mothers were ≥ 25 years compared to those with younger mothers. Positive associations were observed between scores for fruits and maternal education, vegetables and maternal age, added sugars and child weight status, while negative associations were observed between fruits and child age, and vegetable oils and maternal education. Scores for dairy products PHDI-C component were lower among girls.
Conclusion
Adherence to sustainable healthy diets was low among this sample of Chilean children and was significantly associated with maternal age, being lower among children whose mothers were younger.},
keywords = {Entornos Alimentarios y Políticas Públicas en Nutrición. /, L1: Dieta},
pubstate = {published},
tppubtype = {article}
}
- Cómo citar: Venegas Hargous, Carolina & Orellana, Liliana & Corvalán, Camila & Strugnell, Claudia & Allender, Steven & Bell, Andrew. (2024). Chilean children’s adherence to sustainable healthy diets and its associations with sociodemographic and anthropometric factors: a cross-sectional study. European Journal of Nutrition. 10.1007/s00394-024-03435-6.
- Resumen: To describe adherence to sustainable healthy diets among a sample of 958 Chilean pre-schoolers (3–6 years) and explore associations between adherence and child and maternal sociodemographic and anthropometric characteristics.
Methods
Children’s adherence to sustainable healthy diets was calculated from single multiple-pass 24-h dietary recalls using the Planetary Health Diet Index for children and adolescents (PHDI-C). Higher PHDI-C scores (max score = 150 points) represent greater adherence. Adjusted linear regression models were fitted to explore associations between PHDI-C scores and child and maternal characteristics.
Results
Children obtained low total PHDI-C scores (median 50.0 [IQR 39.5–59.8] points). This resulted from low consumption of nuts & peanuts, legumes, vegetables, whole cereals, and vegetable oils; a lack of balance between dark green and red & orange vegetables, inadequate consumption of tubers & potatoes and eggs & white meats, and excess consumption of dairy products, palm oil, red meats, and added sugars. Mean PHDI-C total score was significantly higher (50.6 [95%CI 49.6, 51.7] vs 47.3 [95%CI 45.0, 49.5]) among children whose mothers were ≥ 25 years compared to those with younger mothers. Positive associations were observed between scores for fruits and maternal education, vegetables and maternal age, added sugars and child weight status, while negative associations were observed between fruits and child age, and vegetable oils and maternal education. Scores for dairy products PHDI-C component were lower among girls.
Conclusion
Adherence to sustainable healthy diets was low among this sample of Chilean children and was significantly associated with maternal age, being lower among children whose mothers were younger.